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- Title
Huang-Lian-Jie-Du-Tang exerts anti-inflammatory effects in rats through inhibition of nitric oxide production and eicosanoid biosynthesis via the lipoxygenase pathway.
- Authors
Huawu Zeng; Xiaohua Liu; Shengshan Dou; Wen Xu; Na Li; Xiaojun Liu; Weidong Zhang; Zhenlin Hu; Runhui Liu
- Abstract
The article discusses study which evaluates the anti-inflammatory activity of Huang-Lian-Jie-Du-Tang (HLJDT), a Chinese medicine, in vivo and in vitro. The study employs carrageenan rat air pouch model, liquid chromatography-tandem mass spectrometry (LC-MS/MS), and HPLC-diode array detector (DAD) analysis. Results reveal that HLJDT could inhibit biosynthesis of eicosanoids formed by various lipoxygenases.
- Subjects
CHINESE medicine; ANTI-inflammatory agents; LIQUID chromatography-mass spectrometry; EICOSANOIDS; LIPOXYGENASES
- Publication
Journal of Pharmacy & Pharmacology, 2009, Vol 61, Issue 12, p1699
- ISSN
0022-3573
- Publication type
Academic Journal
- DOI
10.1211/jpp.61.12.0016