Title: Huang-Lian-Jie-Du-Tang exerts anti-inflammatory effects in rats through inhibition of nitric oxide production and eicosanoid biosynthesis via the lipoxygenase pathway.
Authors: Huawu Zeng; Xiaohua Liu; Shengshan Dou; Wen Xu; Na Li; Xiaojun Liu; Weidong Zhang; Zhenlin Hu; Runhui Liu
Abstract: The article discusses study which evaluates the anti-inflammatory activity of Huang-Lian-Jie-Du-Tang (HLJDT), a Chinese medicine, in vivo and in vitro. The study employs carrageenan rat air pouch model, liquid chromatography-tandem mass spectrometry (LC-MS/MS), and HPLC-diode array detector (DAD) analysis. Results reveal that HLJDT could inhibit biosynthesis of eicosanoids formed by various lipoxygenases.
Subjects: CHINESE medicine; ANTI-inflammatory agents; LIQUID chromatography-mass spectrometry; EICOSANOIDS; LIPOXYGENASES
Publication: Journal of Pharmacy & Pharmacology, 2009, Vol 61, Issue 12, p1699
ISSN: 0022-3573
Publication type: Academic Journal
DOI: 10.1211/jpp.61.12.0016

Huang-Lian-Jie-Du-Tang exerts anti-inflammatory effects in rats through inhibition of nitric oxide production and eicosanoid biosynthesis via the lipoxygenase pathway.

Huawu Zeng; Xiaohua Liu; Shengshan Dou; Wen Xu; Na Li; Xiaojun Liu; Weidong Zhang; Zhenlin Hu; Runhui Liu