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- Title
Endothelium-independent vasorelaxation by the selective alpha estrogen receptor agonist propyl pyrazole triol in rat aortic smooth muscle.
- Authors
José Alda; Marta Valero; Desiree Pereboom; Pilar Gros; Ricardo Garay
- Abstract
The article presents a study which investigates the endothelium-independent vasorelaxation by the selective estrogen receptor alpha (ERΑ) agonist propyl pyrazole triol (PPT) in the aortic smooth muscle of rats. The study involves several compounds,such as the protein kinase G (PKG) and potassium channel inhibitors, which were tested against PPT-dependent aortic relaxation. Results show that the endothelial removal has no effect on PPT vasorelaxation.
- Subjects
SELECTIVE estrogen receptor modulators; CGMP-dependent protein kinase; AORTA; SMOOTH muscle; LABORATORY rats
- Publication
Journal of Pharmacy & Pharmacology, 2009, Vol 61, Issue 5, p641
- ISSN
0022-3573
- Publication type
Academic Journal
- DOI
10.1211/jpp.61.05.0013