Title: Endothelium-independent vasorelaxation by the selective alpha estrogen receptor agonist propyl pyrazole triol in rat aortic smooth muscle.
Abstract: The article presents a study which investigates the endothelium-independent vasorelaxation by the selective estrogen receptor alpha (ERΑ) agonist propyl pyrazole triol (PPT) in the aortic smooth muscle of rats. The study involves several compounds,such as the protein kinase G (PKG) and potassium channel inhibitors, which were tested against PPT-dependent aortic relaxation. Results show that the endothelial removal has no effect on PPT vasorelaxation.
Subjects: SELECTIVE estrogen receptor modulators; CGMP-dependent protein kinase; AORTA; SMOOTH muscle; LABORATORY rats
Publication: Journal of Pharmacy & Pharmacology, 2009, Vol 61, Issue 5, p641
ISSN: 0022-3573
Publication type: Academic Journal
DOI: 10.1211/jpp.61.05.0013

Endothelium-independent vasorelaxation by the selective alpha estrogen receptor agonist propyl pyrazole triol in rat aortic smooth muscle.

JosÃ© Alda; Marta Valero; Desiree Pereboom; Pilar Gros; Ricardo Garay