Title: Metabolic interactions with piperazine-based 'party pill' drugs.
Authors: Ushtana Antia; Malcolm Tingle; Bruce Russell
Abstract: The article presents a study which examines the metabolic interactions between piperazine-based party pill drugs and other drugs metabolised by similar cytochrome P450 (CYP) isoenzymes. The study investigates the inhibitory impact of seven benzyl and phenyl piperazines through microbial incubation assays of probe surfaces for five CYP isoenzymes. The study reveals that the piperazine analogues have shown inhibitory activity against most isoenzymes tested.
Subjects: DRUG metabolism; PIPERAZINE; PILLS; CYTOCHROME P-450; ISOENZYMES; BENZYL compounds; PHENYL compounds
Publication: Journal of Pharmacy & Pharmacology, 2009, Vol 61, Issue 7, p877
ISSN: 0022-3573
Publication type: Academic Journal
DOI: 10.1211/jpp/61.07.0006

Metabolic interactions with piperazine-based 'party pill' drugs.

Ushtana Antia; Malcolm Tingle; Bruce Russell