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- Title
Metabolic interactions with piperazine-based 'party pill' drugs.
- Authors
Ushtana Antia; Malcolm Tingle; Bruce Russell
- Abstract
The article presents a study which examines the metabolic interactions between piperazine-based party pill drugs and other drugs metabolised by similar cytochrome P450 (CYP) isoenzymes. The study investigates the inhibitory impact of seven benzyl and phenyl piperazines through microbial incubation assays of probe surfaces for five CYP isoenzymes. The study reveals that the piperazine analogues have shown inhibitory activity against most isoenzymes tested.
- Subjects
DRUG metabolism; PIPERAZINE; PILLS; CYTOCHROME P-450; ISOENZYMES; BENZYL compounds; PHENYL compounds
- Publication
Journal of Pharmacy & Pharmacology, 2009, Vol 61, Issue 7, p877
- ISSN
0022-3573
- Publication type
Academic Journal
- DOI
10.1211/jpp/61.07.0006