Objective:To explore the best method of self-made ice pack before ankle fracture operation. Methods:Sixty patients with an⁃ kle fractures admitted to our department from October 2015 to March 2016 were randomly divided into two groups. The observation group received 25% ethanol ice packs around the ankles, and the control group received ordinary ice packs around the ankles. The pain was assessed by Visual Analog Scale(VAS) at 12 h, 24 h, and 48 h after the fracture. The degree of swelling was evaluated at 24h, 48h, and 72 h after the fracture by measuring ankle circumference. And the length of pre-operative waiting time was recorded. Results: The pain scores of the observation group were lower than those of the control group at 24 h and 48 h after fracture, and the difference was sta⁃ tistically significant(P<0.05). The ankle circumference (swelling degree) of the observation group at 48 h and 72 h after fracture were shorter than those in the control group, and the difference was statistically significant(P<0.05). The length of waiting time of the observa⁃ tion group was shorter than that of the control group, and the difference was statistically significant(P<0.05). Conclusions: The 25% etha⁃ nol ice pack could effectively alleviate the pain of patients with ankle fracture, help the ankle joint to reduce swelling, and shorten the wait⁃ ing time of surgery.