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- Title
Effect of Weight Loss on Liver Free Fatty Acid Uptake and Hepatic Insulin Resistance.
- Authors
Viljanen, Antti P. M.; Iozzo, Patricia; Borra, Ronald; Kankaanpää, Mikko; Karmi, Anna; Lautamäki, Riikka; Järvisalo, Mikko; Parkkola, Riitta; Rönnemaa, Tapani; Guiducci, Letizia; Lehtimäki, Terho; Raitakari, Olli T.; Mari, Andrea; Nuutila, Pirjo
- Abstract
Objective: Weight loss has been shown to decrease liver fat content and whole-body insulin resistance. The current study was conducted to investigate the simultaneous effects of rapid weight reduction with a very-low-calorie diet on liver glucose and fatty acid metabolism and liver adiposity.Hypothesis: We hypothesized that liver insulin resistance and free fatty acid uptake would decrease after weight loss and that they are associated with reduction of liver fat content.Design: Thirty-four healthy obese subjects (body mass index, 33.7 ± 8.0 kg/m2) were studied before and after a very-low-calorie diet for 6 wk. Hepatic glucose uptake and endogenous glucose production were measured with [18F]fluorodeoxyglucose during hyperinsulinemic euglycemia and fasting hepatic fatty acid uptake with [18F]fluoro-6-thia-heptadecanoic acid and positron emission tomography. Liver volume and fat content were measured using magnetic resonance imaging and spectroscopy.Results: Subjects lost weight (11.2 ± 2.9 kg; P < 0.0001). Liver volume decreased by 11% (P < 0.002), which was partly explained by decreased liver fat content (P < 0.0001). Liver free fatty acid uptake was 26% lower after weight loss (P < 0.003) and correlated with the decrement in liver fat content (r = 0.54; P < 0.03). Hepatic glucose uptake during insulin stimulation was unchanged, but the endogenous glucose production decreased by 40% (P < 0.04), and hepatic insulin resistance by 40% (P < 0.05).Conclusions: The liver responds to a 6-wk period of calorie restriction with a parallel reduction in lipid uptake and storage, accompanied by enhancement of hepatic insulin sensitivity and clearance.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2009, Vol 94, Issue 1, p50
- ISSN
0021-972X
- Publication type
Academic Journal
- DOI
10.1210/jc.2008-1689