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- Title
Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women.
- Authors
Masemola, Maphoko; Mendham, Amy E; Micklesfield, Lisa K; Pheiffer, Carmen; Hawley, James; Kengne, Andre Pascal; Chikowore, Tinashe; Kufe, Clement Nyuyki; Crowther, Nigel J; Norris, Shane; Storbeck, Karl-Heinz; Olsson, Tommy; Karpe, Fredrik; Goedecke, Julia H
- Abstract
Objective To explore depot-specific functional aspects of adipose tissue, examining the putative role for menopause and HIV status on insulin sensitivity (SI) and beta-cell function in Black South African women. Methods Women (n = 92) from the Middle-Aged Soweto Cohort, including premenopausal HIV-negative women (n = 21); premenopausal women living with HIV (LWH; n = 11); postmenopausal HIV-negative women (n = 42); and postmenopausal women LWH (n = 18) underwent the following tests: body composition (dual-energy x-ray absorptiometry); fasting bloods for sex hormones, inflammation, and adipokines; frequently sampled intravenous glucose tolerance test for SI and beta-cell function (disposition index, DI); abdominal (aSAT) and gluteal subcutaneous adipose tissue (gSAT) biopsies for cell size, and mRNA expression of adipokines, inflammation, and estrogen receptors (ER). Results Depot-specific associations between gene expression and insulin parameters did not differ by HIV or menopause status. Pooled analysis showed significant models for SI (P =.002) and DI (P =.003). Higher SI was associated with lower leptin and CD11c expression in aSAT and higher adiponectin in gSAT. Higher DI was associated with higher aSAT and gSAT expression of adiponectin, lipoprotein lipase, ERα, and PPARγ, and lower leptin in aSAT. Women LWH had higher expression of adiponectin and lower expression of leptin in both aSAT (P =.002 and P =.005) and gSAT (P =.004 and P =.002), respectively, and a larger proportion of smaller cells in aSAT (P <.001). Conclusion Insulin sensitivity and beta-cell function were distinctively associated with aSAT and gSAT. While menopause did not influence these relationships, HIV had a significant effect on adipose tissue, characterized by variations in cell size distribution and transcript levels within the depots.
- Subjects
BLACK South Africans; BLACK Africans; ESTROGEN receptors; BODY composition; ADIPOSE tissues; ADIPOKINES
- Publication
Journal of Clinical Endocrinology & Metabolism, 2025, Vol 110, Issue 1, p16
- ISSN
0021-972X
- Publication type
Academic Journal
- DOI
10.1210/clinem/dgae447