Works matching AU Mendyk, Aleksander

Results: 41

Application of automated machine learning in the identification of multi‐target‐directed ligands blocking PDE4B, PDE8A, and TRPA1 with potential use in the treatment of asthma and COPD.

Published in:

Molecular Informatics, 2023, v. 42, n. 7, p. 1, doi. 10.1002/minf.202200214

By:

Gawalska, Alicja;
Czub, Natalia;
Sapa, Michał;
Kołaczkowski, Marcin;
Bucki, Adam;
Mendyk, Aleksander

Publication type:

Article

Enhanced QSAR models for drug-triggered inhibition of the main cardiac ion currents.

Published in:

Journal of Applied Toxicology, 2015, v. 35, n. 9, p. 1030, doi. 10.1002/jat.3095

By:

Wiśniowska, Barbara;
Mendyk, Aleksander;
Szlęk, Jakub;
Kołaczkowski, Michał;
Polak, Sebastian

Publication type:

Article

Slow delayed rectifying potassium current ( I<sub>Ks</sub>) - analysis of the in vitro inhibition data and predictive model development.

Published in:

Journal of Applied Toxicology, 2013, v. 33, n. 8, p. 723, doi. 10.1002/jat.2719

By:

Polak, Sebastian;
Wiśniowska, Barbara;
Glinka, Anna;
Fijorek, Kamil;
Mendyk, Aleksander

Publication type:

Article

Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.

Published in:

Journal of Applied Toxicology, 2012, v. 32, n. 10, p. 858, doi. 10.1002/jat.2784

By:

Wiśniowska, Barbara;
Mendyk, Aleksander;
Fijorek, Kamil;
Glinka, Anna;
Polak, Sebastian

Publication type:

Article

Machine Learning for the Identification of Hydration Mechanisms of Pharmaceutical-Grade Cellulose Polymers and Their Mixtures with Model Drugs.

Published in:

Applied Sciences (2076-3417), 2021, v. 11, n. 16, p. 7751, doi. 10.3390/app11167751

By:

Talik, Przemysław;
Mendyk, Aleksander

Publication type:

Article

Bayesian Model Infers Drug Repurposing Candidates for Treatment of COVID-19.

Published in:

Applied Sciences (2076-3417), 2021, v. 11, n. 6, p. 2466, doi. 10.3390/app11062466

By:

Kiebish, Michael A.;
Shah, Punit;
Sarangarajan, Rangaprasad;
Vishnudas, Vivek K.;
Gesta, Stephane;
Tekumalla, Poornima K.;
Bountra, Chas;
Granger, Elder;
Schadt, Eric;
Rodrigues, Leonardo O.;
Narain, Niven R.;
Mendyk, Aleksander;
Divina, Federico

Publication type:

Article

Cocrystal Prediction Using Machine Learning Models and Descriptors.

Published in:

Applied Sciences (2076-3417), 2021, v. 11, n. 3, p. 1323, doi. 10.3390/app11031323

By:

Mswahili, Medard Edmund;
Lee, Min-Jeong;
Martin, Gati Lother;
Kim, Junghyun;
Kim, Paul;
Choi, Guang J.;
Jeong, Young-Seob;
Mendyk, Aleksander

Publication type:

Article

Evolutionary Algorithms in Modeling Aerodynamic Properties of Spray-Dried Microparticulate Systems.

Published in:

Applied Sciences (2076-3417), 2020, v. 10, n. 20, p. 7109, doi. 10.3390/app10207109

By:

Pacławski, Adam;
Szlęk, Jakub;
Jachowicz, Renata;
Giovagnoli, Stefano;
Wiśniowska, Barbara;
Polak, Sebastian;
Czub, Natalia;
Mendyk, Aleksander

Publication type:

Article

Computational Intelligence Modeling of the Macromolecules Release from PLGA Microspheres—Focus on Feature Selection.

Published in:

PLoS ONE, 2016, v. 11, n. 6, p. 1, doi. 10.1371/journal.pone.0157610

By:

Zawbaa, Hossam M.;
Szlȩk, Jakub;
Grosan, Crina;
Jachowicz, Renata;
Mendyk, Aleksander

Publication type:

Article

Formulation development and scale-up of dutasteride liquisolid tablets.

Published in:

Drug Development & Industrial Pharmacy, 2025, v. 51, n. 3, p. 209, doi. 10.1080/03639045.2025.2459184

By:

Woyna-Orlewicz, Krzysztof;
Huszcza, Grzegorz;
Pesta, Edyta;
Strózik, Mirosław;
Kurek, Mateusz;
Antosik-Rogóż, Agata;
Jachowicz, Renata;
Dorożyński, Przemysław;
Mendyk, Aleksander

Publication type:

Article

Electrospun Amorphous Solid Dispersions with Lopinavir and Ritonavir for Improved Solubility and Dissolution Rate.

Published in:

Nanomaterials (2079-4991), 2024, v. 14, n. 19, p. 1569, doi. 10.3390/nano14191569

By:

Łyszczarz, Ewelina;
Sosna, Oskar;
Srebro, Justyna;
Rezka, Aleksandra;
Majda, Dorota;
Mendyk, Aleksander

Publication type:

Article

From Heuristic to Mathematical Modeling of Drugs Dissolution Profiles: Application of Artificial Neural Networks and Genetic Programming.

Published in:

Computational & Mathematical Methods in Medicine, 2015, v. 2015, p. 1, doi. 10.1155/2015/863874

By:

Mendyk, Aleksander;
Güres, Sinan;
Jachowicz, Renata;
Szlęk, Jakub;
Polak, Sebastian;
Wiśniowska, Barbara;
Kleinebudde, Peter

Publication type:

Article

Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 5, p. 663, doi. 10.1007/s10928-018-9597-6

By:

Tylutki, Zofia;
Mendyk, Aleksander;
Polak, Sebastian

Publication type:

Article

Hydrożele jako skuteczne materiały opatrunkowe we wspomaganiu leczenia ran.

Published in:

Farmacja Polska, 2023, v. 79, n. 4, p. 217, doi. 10.32383/farmpol/172007

By:

Górska, Anna;
Mendyk, Aleksander

Publication type:

Article

Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools.

Published in:

Computational & Mathematical Methods in Medicine, 2018, p. 1, doi. 10.1155/2018/3719703

By:

Polak, Sebastian;
Wiśniowska, Barbara;
Mendyk, Aleksander;
Pacławski, Adam;
Szlęk, Jakub

Publication type:

Article

Virtual population generator for human cardiomyocytes parameters: in silico drug cardiotoxicity assessment.

Published in:

Toxicology Mechanisms & Methods, 2012, v. 22, n. 1, p. 31, doi. 10.3109/15376516.2011.585477

By:

Polak, Sebastian;
Fijorek, Kamil;
Glinka, Anna;
Wisniowska, Barbara;
Mendyk, Aleksander

Publication type:

Article

Empirical modeling of the fine particle fraction for carrier-based pulmonary delivery formulations.

Published in:

International Journal of Nanomedicine, 2015, v. 10, p. 801, doi. 10.2147/IJN.S75758

By:

Pacławski, Adam;
Szlęk, Jakub;
Lau, Raymond;
Jachowicz, Renata;
Mendyk, Aleksander

Publication type:

Article

Heuristic modeling of macromolecule release from PLGA microspheres.

Published in:

International Journal of Nanomedicine, 2013, v. 8, p. 4601, doi. 10.2147/IJN.S53364

By:

Szlęk, Jakub;
Pacławski, Adam;
Lau, Raymond;
Jachowicz, Renata;
Mendyk, Aleksander

Publication type:

Article

Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride Orally Disintegrating Tablets (ODTs).

Published in:

Pharmaceutical Research, 2023, v. 40, n. 12, p. 2947, doi. 10.1007/s11095-023-03605-x

By:

Woyna-Orlewicz, Krzysztof;
Brniak, Witold;
Tatara, Wiktor;
Strzebońska, Magdalena;
Haznar-Garbacz, Dorota;
Szafraniec-Szczęsny, Joanna;
Antosik-Rogóż, Agata;
Wojteczko, Kamil;
Strózik, Mirosław;
Kurek, Mateusz;
Jachowicz, Renata;
Mendyk, Aleksander

Publication type:

Article

Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges.

Published in:

2014

By:

Wisniowska, Barbara;
Mendyk, Aleksander;
Fijorek, Kamil;
Polak, Sebastian

Publication type:

Journal Article

Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges.

Published in:

EP: Europace, 2014, v. 16, n. 5, p. 724

By:

Wiśniowska, Barbara;
Mendyk, Aleksander;
Fijorek, Kamil;
Polak, Sebastian

Publication type:

Article

Drug Therapy Optimization System Based on a Hybrid Approach Combining Clinical Data and In Silico Modeling - Perspective View and Concept Description.

Published in:

International Review on Modelling & Simulations, 2020, v. 13, n. 4, p. 234, doi. 10.15866/iremos.v13i4.19200

By:

Baliś, Bartosz;
Byrski, Aleksander;
Dekster, Lena;
Frącz, Wojciech;
Giebułtowicz, Joanna;
Kisiel-Dorohinicki, Marek;
Mendyk, Aleksander;
Pawlik, Maciej;
Piotrowski, Roman;
Turek, Wojciech;
Wiśniowska, Barbara;
Polak, Sebastian

Publication type:

Article

Initial Development of Automated Machine Learning-Assisted Prediction Tools for Aryl Hydrocarbon Receptor Activators.

Published in:

Pharmaceutics, 2024, v. 16, n. 11, p. 1456, doi. 10.3390/pharmaceutics16111456

By:

Wojtyło, Paulina Anna;
Łapińska, Natalia;
Bellagamba, Lucia;
Camaioni, Emidio;
Mendyk, Aleksander;
Giovagnoli, Stefano

Publication type:

Article

Physically Cross-Linked PVA Hydrogels as Potential Wound Dressings: How Freezing Conditions and Formulation Composition Define Cryogel Structure and Performance.

Published in:

Pharmaceutics, 2024, v. 16, n. 11, p. 1388, doi. 10.3390/pharmaceutics16111388

By:

Górska, Anna;
Baran, Ewelina;
Knapik-Kowalczuk, Justyna;
Szafraniec-Szczęsny, Joanna;
Paluch, Marian;
Kulinowski, Piotr;
Mendyk, Aleksander

Publication type:

Article

Application of Hydrophilic Polymers to the Preparation of Prolonged-Release Minitablets with Bromhexine Hydrochloride and Bisoprolol Fumarate.

Published in:

Pharmaceutics, 2024, v. 16, n. 9, p. 1153, doi. 10.3390/pharmaceutics16091153

By:

Grzejdziak, Agata;
Brniak, Witold;
Lengier, Olaf;
Żarek, Justyna Anna;
Hliabovich, Dziyana;
Mendyk, Aleksander

Publication type:

Article

Integrated QSAR Models for Prediction of Serotonergic Activity: Machine Learning Unveiling Activity and Selectivity Patterns of Molecular Descriptors.

Published in:

Pharmaceutics, 2024, v. 16, n. 3, p. 349, doi. 10.3390/pharmaceutics16030349

By:

Łapińska, Natalia;
Pacławski, Adam;
Szlęk, Jakub;
Mendyk, Aleksander

Publication type:

Article

Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives.

Published in:

Pharmaceutics, 2022, v. 14, n. 10, p. N.PAG, doi. 10.3390/pharmaceutics14102043

By:

Srebro, Justyna;
Brniak, Witold;
Mendyk, Aleksander

Publication type:

Article

Do AutoML-Based QSAR Models Fulfill OECD Principles for Regulatory Assessment? A 5-HT 1A Receptor Case.

Published in:

Pharmaceutics, 2022, v. 14, n. 7, p. N.PAG, doi. 10.3390/pharmaceutics14071415

By:

Czub, Natalia;
Pacławski, Adam;
Szlęk, Jakub;
Mendyk, Aleksander

Publication type:

Article

Puzzle out Machine Learning Model-Explaining Disintegration Process in ODTs.

Published in:

Pharmaceutics, 2022, v. 14, n. 4, p. N.PAG, doi. 10.3390/pharmaceutics14040859

By:

Szlęk, Jakub;
Khalid, Mohammad Hassan;
Pacławski, Adam;
Czub, Natalia;
Mendyk, Aleksander

Publication type:

Article

Application and Multi-Stage Optimization of Daylight Polymer 3D Printing of Personalized Medicine Products.

Published in:

Pharmaceutics, 2022, v. 14, n. 4, p. N.PAG, doi. 10.3390/pharmaceutics14040843

By:

Pyteraf, Jolanta;
Pacławski, Adam;
Jamróz, Witold;
Mendyk, Aleksander;
Paluch, Marian;
Jachowicz, Renata

Publication type:

Article

Curated Database and Preliminary AutoML QSAR Model for 5-HT1A Receptor.

Published in:

Pharmaceutics, 2021, v. 13, n. 10, p. 1711, doi. 10.3390/pharmaceutics13101711

By:

Czub, Natalia;
Pacławski, Adam;
Szlęk, Jakub;
Mendyk, Aleksander

Publication type:

Article

Orodispersible Dosage Forms with Rhinacanthin-Rich Extract as a Convenient Formulation Dedicated to Pediatric Patients.

Published in:

Pharmaceuticals (14248247), 2024, v. 17, n. 8, p. 994, doi. 10.3390/ph17080994

By:

Suksawat, Thongtham;
Brniak, Witold;
Łyszczarz, Ewelina;
Wesoły, Małgorzata;
Ciosek-Skibińska, Patrycja;
Mendyk, Aleksander

Publication type:

Article

COMPUTATIONAL INTELLIGENCE FOR PREDICTING BIOLOGICAL EFFECTS OF DRUG ABSORPTION IN LUNGS.

Published in:

Computer Science, 2019, v. 20, n. 1, p. 99, doi. 10.7494/csci.2019.20.1.2992

By:

PACŁAWSKI, ADAM;
SZLEK, JAKUB;
MENDYK, ALEKSANDER

Publication type:

Article

Machine Learning Tool for New Selective Serotonin and Serotonin–Norepinephrine Reuptake Inhibitors.

Published in:

Molecules, 2025, v. 30, n. 3, p. 637, doi. 10.3390/molecules30030637

By:

Łapińska, Natalia;
Szlęk, Jakub;
Pacławski, Adam;
Mendyk, Aleksander

Publication type:

Article

Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from 'Golem': A Novel Apparatus.

Published in:

2015

By:

ulen, Martin;
Tuszynski, Pawel K;
Polak, Sebastian;
Jachowicz, Renata;
Mendyk, Aleksander;
Dohnal, Jií

Publication type:

Journal Article

Effect of roll compaction on granule size distribution of microcrystalline cellulose--mannitol mixtures: computational intelligence modeling and parametric analysis.

Published in:

Drug Design, Development & Therapy, 2017, v. 11, p. 241, doi. 10.2147/DDDT.S124670

By:

Kazemi, Pezhman;
Khalid, Mohammad Hassan;
Gago, Ana Pérez;
Kleinebudde, Peter;
Jachowicz, Renata;
Szlęk, Jakub;
Mendyk, Aleksander

Publication type:

Article

Computational intelligence models to predict porosity of tablets using minimum features.

Published in:

Drug Design, Development & Therapy, 2017, v. 11, p. 193, doi. 10.2147/DDDT.S119432

By:

Khalid, Mohammad Hassan;
Kazemi, Pezhman;
Perez-Gandarillas, Lucia;
Michrafy, Abderrahim;
Szlęk, Jakub;
Jachowicz, Renata;
Mendyk, Aleksander

Publication type:

Article

Generalized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks.

Published in:

Drug Design, Development & Therapy, 2013, v. 7, p. 223, doi. 10.2147/DDDT.S41401

By:

Mendyk, Aleksander;
Tuszynski, Pawel K.;
Polak, Sebastian;
Jachowicz, Renata

Publication type:

Article

Data-Driven Modeling of the Bicalutamide Dissolution from Powder Systems.

Published in:

AAPS PharmSciTech, 2020, v. 21, n. 3, p. 1, doi. 10.1208/s12249-020-01660-w

By:

Mendyk, Aleksander;
Pacławski, Adam;
Szafraniec-Szczęsny, Joanna;
Antosik, Agata;
Jamróz, Witold;
Paluch, Marian;
Jachowicz, Renata

Publication type:

Article

The Relationship Between the Evolution of an Internal Structure and Drug Dissolution from Controlled-Release Matrix Tablets.

Published in:

AAPS PharmSciTech, 2016, v. 17, n. 3, p. 735, doi. 10.1208/s12249-015-0402-1

By:

Kulinowski, Piotr;
Hudy, Wiktor;
Mendyk, Aleksander;
Juszczyk, Ewelina;
Węglarz, Władysław;
Jachowicz, Renata;
Dorożyński, Przemysław

Publication type:

Article

Novel Application of MRI Technique Combined with Flow-Through Cell Dissolution Apparatus as Supportive Discriminatory Test for Evaluation of Controlled Release Formulations.

Published in:

AAPS PharmSciTech, 2010, v. 11, n. 2, p. 588, doi. 10.1208/s12249-010-9418-8

By:

Dorożyński, Przemyslaw;
Kulinowski, Piotr;
Mendyk, Aleksander;
Młynarczyk, Anna;
Jachowicz, Renata

Publication type:

Article