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Application of Physiologically Based Pharmacokinetic Model to Delineate the Impact of Aging and Renal Impairment on Ceftazidime Clearance.
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- Antibiotics (2079-6382), 2024, v. 13, n. 9, p. 862, doi. 10.3390/antibiotics13090862
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- Article
A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes.
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- Antibodies (2073-4468), 2024, v. 13, n. 3, p. 70, doi. 10.3390/antib13030070
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- Article
Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 8, p. 1060, doi. 10.1002/psp4.12814
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- Article
Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers.
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- CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 6, p. 755, doi. 10.1002/psp4.12787
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- Article
Predicting Nonlinear Pharmacokinetics of Omeprazole Enantiomers and Racemic Drug Using Physiologically Based Pharmacokinetic Modeling and Simulation: Application to Predict Drug/Genetic Interactions.
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- Pharmaceutical Research, 2014, v. 31, n. 8, p. 1919, doi. 10.1007/s11095-013-1293-z
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- Article
A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution.
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- Journal of Pharmacy & Pharmacology, 2012, v. 64, n. 7, p. 1008, doi. 10.1111/j.2042-7158.2012.01538.x
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- Article
Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic Models.
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- AAPS Journal, 2020, v. 22, n. 5, p. N.PAG, doi. 10.1208/s12248-020-00480-x
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- Article
Development and Application of a Physiologically-Based Pharmacokinetic Model to Predict the Pharmacokinetics of Therapeutic Proteins from Full-term Neonates to Adolescents.
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- AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00460-1
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- Article
What Does it Take to Make Model-Informed Precision Dosing Common Practice? Report from the 1st Asian Symposium on Precision Dosing.
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- AAPS Journal, 2019, v. 21, n. 2, p. 1, doi. 10.1208/s12248-018-0286-6
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- Article
Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram.
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- AAPS Journal, 2018, v. 20, n. 1, p. 1, doi. 10.1208/s12248-017-0155-8
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- Article
Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs.
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- AAPS Journal, 2017, v. 19, n. 4, p. 1205, doi. 10.1208/s12248-017-0099-z
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- Article
Examining the Use of a Mechanistic Model to Generate an In Vivo/ In Vitro Correlation: Journey Through a Thought Process.
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- AAPS Journal, 2016, v. 18, n. 5, p. 1144, doi. 10.1208/s12248-016-9930-1
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- Article
A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins.
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- AAPS Journal, 2016, v. 18, n. 1, p. 156, doi. 10.1208/s12248-015-9819-4
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- Article
Are Physiologically Based Pharmacokinetic Models Reporting the Right C? Central Venous Versus Peripheral Sampling Site.
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- AAPS Journal, 2015, v. 17, n. 5, p. 1268, doi. 10.1208/s12248-015-9796-7
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- Article
Simulation of Monoclonal Antibody Pharmacokinetics in HumansUsing a Minimal Physiologically Based Model.
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- AAPS Journal, 2014, v. 16, n. 5, p. 1097, doi. 10.1208/s12248-014-9640-5
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- Publication type:
- Article
Changes in Individual Drug-Independent System Parameters during Virtual Paediatric Pharmacokinetic Trials: Introducing Time-Varying Physiology into a Paediatric PBPK Model.
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- AAPS Journal, 2014, v. 16, n. 3, p. 568, doi. 10.1208/s12248-014-9592-9
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- Article
Population-Based Mechanistic Prediction of Oral Drug Absorption.
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- AAPS Journal, 2009, v. 11, n. 2, p. 225, doi. 10.1208/s12248-009-9099-y
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- Article
Accelerating the Progress of Kinase Inhibitors in Oncology.
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- Applied Clinical Trials, 2024, v. 33, n. 5, p. 16
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- Article
Physiologically-based pharmacokinetic modeling to predict drug-drug interaction of enzalutamide with combined P-gp and CYP3A substrates.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2023, v. 50, n. 5, p. 365, doi. 10.1007/s10928-023-09867-7
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- Article
Prediction of maternal pharmacokinetics using physiologically based pharmacokinetic models: assessing the impact of the longitudinal changes in the activity of CYP1A2, CYP2D6 and CYP3A4 enzymes during pregnancy.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 4, p. 361, doi. 10.1007/s10928-020-09711-2
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- Article
Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development.
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- Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 3, p. 457, doi. 10.1007/s10928-018-9580-2
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- Article
Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.
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- Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00258
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- Article
Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA.
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- Journal of Psychopharmacology, 2006, v. 20, n. 6, p. 842, doi. 10.1177/0269881106065907
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- Article
Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs.
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- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 11, p. 1382, doi. 10.1002/psp4.12707
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- Article
Prediction of drug concentrations in milk during breastfeeding, integrating predictive algorithms within a physiologically‐based pharmacokinetic model.
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- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 8, p. 878, doi. 10.1002/psp4.12662
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- Article
Where Do PBPK Models Stand in Pharmacometrics and Systems Pharmacology?
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- CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 2, p. 75, doi. 10.1002/psp4.12493
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- Article
Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz.
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- Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00247
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- Article
Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis.
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- Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 6, p. 1264, doi. 10.1002/cpt.3032
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- Article
A pregnancy physiologically based pharmacokinetic (p- PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4.
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- British Journal of Clinical Pharmacology, 2012, v. 74, n. 5, p. 873, doi. 10.1111/j.1365-2125.2012.04363.x
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- Article
Prediction of basic drug exposure in milk using a lactation model algorithm integrated within a physiologically based pharmacokinetic model.
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- Biopharmaceutics & Drug Disposition, 2022, v. 43, n. 5, p. 201, doi. 10.1002/bdd.2334
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- Article
Prediction of liver volume - a population-based approach to meta-analysis of paediatric, adult and geriatric populations - an update.
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- Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 4, p. 290, doi. 10.1002/bdd.2063
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- Article
Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults.
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- Biopharmaceutics & Drug Disposition, 2015, v. 36, n. 4, p. 245, doi. 10.1002/bdd.1937
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- Article
Prediction of the pharmacokinetics, pharmacodynamics, and efficacy of a monoclonal antibody, using a physiologically based pharmacokinetic FcRn model.
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- Frontiers in Immunology, 2015, v. 5, p. 1, doi. 10.3389/fimmu.2014.00670
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- Article
Pharmacokinetics under the COVID‐19 storm.
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- British Journal of Clinical Pharmacology, 2023, v. 89, n. 1, p. 158, doi. 10.1111/bcp.14668
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- Article
Prediction of Maternal and Fetal Acyclovir, Emtricitabine, Lamivudine, and Metformin Concentrations during Pregnancy Using a Physiologically Based Pharmacokinetic Modeling Approach.
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- 2022
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- Publication type:
- journal article
Authors' Reply to Völler et al: "Comment on: Preterm Physiologically Based Pharmacokinetic Model, Part I and Part II".
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- 2021
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- Publication type:
- letter
Fetal Physiologically Based Pharmacokinetic Models: Systems Information on Fetal Blood Components and Binding Proteins.
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- 2020
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- Publication type:
- journal article
Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population.
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- 2020
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- Publication type:
- journal article
A Preterm Physiologically Based Pharmacokinetic Model. Part I: Physiological Parameters and Model Building.
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- 2020
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- Publication type:
- journal article
Fetal Physiologically Based Pharmacokinetic Models: Systems Information on the Growth and Composition of Fetal Organs.
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- 2019
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- Publication type:
- journal article
Prediction of Voriconazole Non-linear Pharmacokinetics Using a Paediatric Physiologically Based Pharmacokinetic Modelling Approach.
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- Clinical Pharmacokinetics, 2015, v. 54, n. 5, p. 567, doi. 10.1007/s40262-015-0247-5
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- Publication type:
- Article
Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients.
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- Clinical Pharmacokinetics, 2011, v. 50, n. 12, p. 809, doi. 10.2165/11594420-000000000-00000
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- Publication type:
- Article
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
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- 2011
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- Publication type:
- journal article
An Application of a Physiologically Based Pharmacokinetic Approach to Predict Ceftazidime Pharmacokinetics in a Pregnant Population.
- Published in:
- Pharmaceutics, 2024, v. 16, n. 4, p. 474, doi. 10.3390/pharmaceutics16040474
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- Publication type:
- Article
Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents.
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- Pharmaceutics, 2021, v. 13, n. 8, p. 1169, doi. 10.3390/pharmaceutics13081169
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- Publication type:
- Article
Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen.
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- Pharmaceutics, 2020, v. 12, n. 11, p. 1049, doi. 10.3390/pharmaceutics12111049
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- Article
Developing Clinically Relevant Dissolution Specifications for Oral Drug Products—Industrial and Regulatory Perspectives.
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- Pharmaceutics, 2020, v. 12, n. 1, p. 19, doi. 10.3390/pharmaceutics12010019
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- Article