Works matching IS 15507416 AND DT 2014 AND VI 16 AND IP 5

Results: 25

G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of In Vitro Drug Product Dissolution and In Vivo Bioavailability, Pharm Res 12, 413-420, 1995-Backstory of BCS.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 894, doi. 10.1208/s12248-014-9620-9

By:

Shah, Vinod;
Amidon, Gordon

Publication type:

Article

Population Pharmacokinetic Modeling of LY2189102 after Multiple Intravenous and Subcutaneous Administrations.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1009, doi. 10.1208/s12248-014-9623-6

By:

Bihorel, Sébastien;
Fiedler-Kelly, Jill;
Ludwig, Elizabeth;
Sloan-Lancaster, Joanne;
Raddad, Eyas

Publication type:

Article

Development of a Poly (lactic-co-glycolic acid) Particle Vaccine to Protect Against House Dust Mite Induced Allergy.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 975, doi. 10.1208/s12248-014-9624-5

By:

Joshi, Vijaya;
Adamcakova-Dodd, Andrea;
Jing, Xuefang;
Wongrakpanich, Amaraporn;
Gibson-Corley, Katherine;
Thorne, Peter;
Salem, Aliasger

Publication type:

Article

Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1029, doi. 10.1208/s12248-014-9625-4

By:

Kervezee, Laura;
Hartman, Robin;
Berg, Dirk-Jan;
Shimizu, Shinji;
Emoto-Yamamoto, Yumi;
Meijer, Johanna;
Lange, Elizabeth

Publication type:

Article

Application of a Physiologically Based Pharmacokinetic Model Informed by a Top-Down Approach for the Prediction of Pharmacokinetics in Chronic Kidney Disease Patients.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1018, doi. 10.1208/s12248-014-9626-3

By:

Sayama, Hiroyuki;
Takubo, Hiroaki;
Komura, Hiroshi;
Kogayu, Motohiro;
Iwaki, Masahiro

Publication type:

Article

Effects of Replacement of Factor VIII Amino Acids Asp519 and Glu665 with Val on Plasma Survival and Efficacy In Vivo.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1038, doi. 10.1208/s12248-014-9627-2

By:

Kosloski, Matthew;
Shetty, Krithika;
Wakabayashi, Hironao;
Fay, Philip;
Balu-Iyer, Sathy

Publication type:

Article

An Electrically Tight In Vitro Blood-Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1046, doi. 10.1208/s12248-014-9628-1

By:

Helms, Hans;
Hersom, Maria;
Kuhlmann, Louise;
Badolo, Lasina;
Nielsen, Carsten;
Brodin, Birger

Publication type:

Article

Light Obscuration Measurements of Highly Viscous Solutions: Sample Pressurization Overcomes Underestimation of Subvisible Particle Counts.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1128, doi. 10.1208/s12248-014-9629-0

By:

Weinbuch, Daniel;
Jiskoot, Wim;
Hawe, Andrea

Publication type:

Article

Completeness Assessment of Type II Active Pharmaceutical Ingredient Drug Master Files under Generic Drug User Fee Amendment: Review Metrics and Common Incomplete Items.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1132, doi. 10.1208/s12248-014-9630-7

By:

Zhang, Huyi;
Li, Haitao;
Song, Wei;
Shen, Diandian;
Skanchy, David;
Shen, Kun;
Lionberger, Robert;
Rosencrance, Susan;
Yu, Lawrence

Publication type:

Article

Lower Exposure and Faster Clearance of Bevacizumab in Gastric Cancer and the Impact of Patient Variables: Analysis of Individual Data from AVAGAST Phase III Trial.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1056, doi. 10.1208/s12248-014-9631-6

By:

Han, Kelong;
Jin, Jin;
Maia, Mauricio;
Lowe, John;
Sersch, Martina;
Allison, David

Publication type:

Article

Small Molecule Specific Run Acceptance, Specific Assay Operation, and Chromatographic Run Quality Assessment: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Teams.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 885, doi. 10.1208/s12248-014-9633-4

By:

Woolf, Eric;
McDougall, Stuart;
Fast, Douglas;
Andraus, Maristela;
Barfield, Matthew;
Blackburn, Michael;
Gordon, Ben;
Hoffman, David;
Inoue, Noriko;
Marcelin-Jimenez, Gabriel;
Flynn, Amy;
LeLacheur, Richard;
Reuschel, Scott;
Santhanam, Ravisankar;
Bennett, Patrick;
Duncan, Barbara;
Hayes, Roger;
Lausecker, Berthold;
Sharma, Abhishek;
Togashi, Kazutaka

Publication type:

Article

Dashboard Systems: Implementing Pharmacometrics from Bench to Bedside.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 925, doi. 10.1208/s12248-014-9632-5

By:

Mould, Diane;
Upton, Richard;
Wojciechowski, Jessica

Publication type:

Article

Simulation of Monoclonal Antibody Pharmacokinetics in HumansUsing a Minimal Physiologically Based Model.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1097, doi. 10.1208/s12248-014-9640-5

By:

Li, Linzhong;
Gardner, Iain;
Dostalek, Miroslav;
Jamei, Masoud

Publication type:

Article

Efficacious Intestinal Permeation Enhancement Induced by the Sodium Salt of 10-undecylenic Acid, A Medium Chain Fatty Acid Derivative.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1064, doi. 10.1208/s12248-014-9634-3

By:

Brayden, David;
Walsh, Edwin

Publication type:

Article

Predicting when Biliary Excretion of Parent Drug is a Major Route of Elimination in Humans.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1085, doi. 10.1208/s12248-014-9636-1

By:

Hosey, Chelsea;
Broccatelli, Fabio;
Benet, Leslie

Publication type:

Article

Biological Products for the Treatment of Psoriasis: Therapeutic Targets, Pharmacodynamics and Disease-Drug-Drug Interaction Implications.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 938, doi. 10.1208/s12248-014-9637-0

By:

Wang, Jie;
Wang, Yow-Ming;
Ahn, Hae-Young

Publication type:

Article

Prodrug Applications for Targeted Cancer Therapy.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 899, doi. 10.1208/s12248-014-9638-z

By:

Giang, Irene;
Boland, Erin;
Poon, Gregory

Publication type:

Article

Physiologically Based Absorption Modelling to Predict the Impact of Drug Properties on Pharmacokinetics of Bitopertin.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1077, doi. 10.1208/s12248-014-9639-y

By:

Parrott, Neil;
Hainzl, Dominik;
Scheubel, Emmanuel;
Krimmer, Siegfried;
Boetsch, Christophe;
Guerini, Elena;
Martin-Facklam, Meret

Publication type:

Article

Induction of Death Receptor CD95 and Co-stimulatory Molecules CD80 and CD86 by Meningococcal Capsular Polysaccharide-Loaded Vaccine Nanoparticles.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 986, doi. 10.1208/s12248-014-9635-2

By:

Ubale, Ruhi;
Gala, Rikhav;
Zughaier, Susu;
D'Souza, Martin

Publication type:

Article

Statistical Power Calculations for Mixed Pharmacokinetic Study Designs Using a Population Approach.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1110, doi. 10.1208/s12248-014-9641-4

By:

Kloprogge, Frank;
Simpson, Julie;
Day, Nicholas;
White, Nicholas;
Tarning, Joel

Publication type:

Article

GATG Dendrimers and PEGylated Block Copolymers: from Synthesis to Bioapplications.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 948, doi. 10.1208/s12248-014-9642-3

By:

Sousa-Herves, Ana;
Novoa-Carballal, Ramon;
Riguera, Ricardo;
Fernandez-Megia, Eduardo

Publication type:

Article

Next Generation Ligand Binding Assays-Review of Emerging Real-Time Measurement Technologies.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 914, doi. 10.1208/s12248-014-9643-2

By:

Fraser, Stephanie;
Cameron, Mark;
O'Connor, Edward;
Schwickart, Martin;
Tanen, Michael;
Ware, Mark

Publication type:

Article

Effect of Excipients on the Particle Size of Precipitated Pioglitazone in the Gastrointestinal Tract: Impact on Bioequivalence.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 1119, doi. 10.1208/s12248-014-9646-z

By:

Sugita, Masaru;
Kataoka, Makoto;
Sugihara, Masahisa;
Takeuchi, Susumu;
Yamashita, Shinji

Publication type:

Article

Making the Most of Clinical Data: Reviewing the Role of Pharmacokinetic-Pharmacodynamic Models of Anti-malarial Drugs.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 962, doi. 10.1208/s12248-014-9647-y

By:

Simpson, Julie;
Zaloumis, Sophie;
DeLivera, Alysha;
Price, Ric;
McCaw, James

Publication type:

Article

A Mechanistic Pharmacokinetic Model Elucidating the Disposition of Trastuzumab Emtansine (T-DM1), an Antibody-Drug Conjugate (ADC) for Treatment of Metastatic Breast Cancer.

Published in:

AAPS Journal, 2014, v. 16, n. 5, p. 994, doi. 10.1208/s12248-014-9618-3

By:

Bender, Brendan;
Leipold, Douglas;
Xu, Keyang;
Shen, Ben-Quan;
Tibbitts, Jay;
Friberg, Lena

Publication type:

Article