组织蛋白酶在神经系统变性疾病中的研究进展.

姚思彤; 徐薇淇; 丛树艳

Cathepsins, the most abundant hydrolases in lysosomes, are responsible for the degradation of various substrates. Increasing evidence suggests that cathepsins play important roles in neurodegenerative diseases. Cathepsins affect the progression of diseases by regulating the aggregation of abnormal proteins (e.g. α-synuclein, amyloid β-protein, huntington) . Abnormal expression levels and activity and gene mutations of cathepsin B, D, and L in the nervous system can lead to the occurrence and development of neurodegenerative diseases. This review summarizes the research progress on cathepsins in neurodegenerative diseases in recent years, with a view to providing a basis for the early diagnosis and treatment of these diseases.

CATHEPSIN B; CATHEPSINS; NEURODEGENERATION; DISEASE progression; GENE expression

Journal of China Medical University, 2024, Vol 53, Issue 11, p1036

0258-4646

Academic Journal

10.12007/j.issn.0258‐4646.2024.11.014