结直肠癌中 TXNIP 和 KLF9 的表达对患者临床特征及预后的影响.

杨婕琳; 王晓媛; 武雪亮

Objective To investigate TXNIP and KLF9 expressions in the tissues of colorectal cancer (CRC) and their impact on clinical characteristics and prognosis. Methods This study included 90 CRC patients who were admitted to our hospital between January 2017 and December 2020. The cancer tissue and paired adjacent tissues removed surgically were collected. We performed detection and analysis of TXNIP and KLF9 protein expression levels in cancer and adjacent tissues and their correlation with clinical characteristics and overall survival rate of patients. Results GEPIA database analysis showed that TXNIP and KLF9 mRNA expression levels in READ tissues were significantly lower than those in normal tissues (P < 0.05) . The positive expression rates of TXNIP and KLF9 in CRC tissues were 32.22% and 37.78%, respectively, which were lower than those in adjacent tissues (73.33% and 76.67%, respectively; P < 0.05) . TXNIP and KLF9 expressions were positively correlated (r = 0.519, P < 0.05), and GEPIA database retrieval showed a positive correlation between TXNIP and KLF9 expressions (P < 0.05) . TXNIP and KLF9 expressions in patients with clinical stage Ⅲ and lymph node metastasis were lower than those in patients with stageⅠ/Ⅱand non-lymph node metastasis (P < 0.05) . The overall survival rate of patients with TXNIP and KLF9 expressions was higher than that of patients without TXNIP and KLF9 expressions. Negative expression of TXNIP and KLF9 in TNM stage Ⅲ was a prognostic risk factor (P < 0.05) . Conclusion TXNIP and KLF9 expression levels are low in CRC tissues and associated with TNM stage, lymph node metastasis, and poor survival.

GENE expression; THIOREDOXIN-interacting protein; LYMPHATIC metastasis; OVERALL survival; SURVIVAL rate

Journal of China Medical University, 2024, Vol 53, Issue 11, p1005

0258-4646

Academic Journal

10.12007/j.issn.0258‐4646.2024.11.009