血清肌酸激酶和肌红蛋白在儿童急性良性肌炎中的 变化特点及临床价值.

苏梓涵; 张乾忠; 姜红堃

Objective To explore the changes in serum creatine kinase (CK) and myoglobin (Mb) levels in benign acute childhood myositis (BACM) and their clinical significance. Methods The clinical data of 78 children with BACM treated in our hospital from January 2011 to December 2023 were collected, and the dynamic changes and clinical performance of serum CK and Mb levels were retrospectively analyzed. Results The CK levels of the 78 patients ranged from 432 U/L to 18 440 U/L, with the mean level being 2 178.8 U/L. The levels exceeded the upper reference limit (310 U/L) in all the patients. They were 2 and 10 times the upper reference limit in 72 (92.31%) and 15 (19.23%) patients, respectively, and were greater than 5 000 U/L in 5 (6.41%) patients and greater than 10 000 U/L in 1 patient. The CK level usually peaked in the first 3 days of BACM onset before decreasing gradually. By the 7th day, CK levels in 73% of the cases decreased to the normal reference range, which was consistent with the change in clinical symptoms. Serum Mb samples were collected from 66 patients, and the levels ranged from 13.3 ng/mL to 2 603.8 ng/mL, with the mean level being 260.17 ng/mL. In 34 patients (51.52%), the Mb levels were higher than the upper reference limit (116.3 ng/mL) . Among these patients, 20 (30.30%), 7 (10.61%), and 3 (4.55%) patients had Mb levels 2, 5, and 10 times higher than the upper reference limit, respectively. Serum Mb levels peaked in the first 3 days of BACM onset and then decreased quickly. Furthermore, in 84.38% of the total cases, serum Mb levels decreased to the normal reference range by the 5th day of onset. Conclusion Serum CK levels in children with BACM are significantly increased, consistent with the changes in clinical symptoms, and therefore, could be regarded as an important basis for BACM diagnosis. Furthermore, serum Mb levels increase to varying extents, indicating a great reference value in BACM diagnosis, and should be tested simultaneously with serum CK. Testing for serum CK and Mb is of great significance for understanding the clinical conditions and guiding the treatment of BACM.

REFERENCE values; CREATINE kinase; MYOGLOBIN; MYOSITIS; SYMPTOMS

Journal of China Medical University, 2024, Vol 53, Issue 11, p984

0258-4646

Academic Journal