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- Title
Validity of the Systemic Lupus Erythematosus Disease Activity 2000-Glucocorticoid Index, its association with the Physician Global Assessment, and potential association with disease damage.
- Authors
Medhat, Basma M.; Maged, Lobna A.; Teleb, Doaa A.; Mohamed, Sally S.; Afifi, Angie Y.; Koptan, Dina M. T.; Abdelrahman, Walaa; Dorgham, Dalia; Elsebaie, Eman Hany; Afifi, Naglaa; Ahmed, Sahar A.; Behairy, Mervat E.; Ramadan, Hala
- Abstract
Background: The Systemic Lupus Erythematosus Disease Activity-2000 Glucocorticoid Index (SLEDAI-2 KG) accounts for glucocorticoids and possibly promising. The Physician Global Assessment (PGA) is subjective and debatable. Objectives: Assessment of the validity of the SLEDAI-2 KG, its association with the PGA, and their potential association with the disease damage. Methods: A cross-sectional study included SLE patients managed at 2 tertiary centers in Egypt were conducted. The SLEDAI-2 K was the gold standard score for assessment the disease activity. The SLEDAI-2 KG incorporates glucocorticoids' dosage through an ordinal weight. The PGA (scale: 0–3) was categorized according to the PGA international standardization consensus in SLE study (PISCOS). Results: The study included 608 patients [546 (89.8%) females and [62 (10.2%) males; age at onset: 27.5 ± 8.5 years; age at assessment: 31.4 ± 9.4 years; disease duration: 6.1 ± 5.5 years for females]. The mean SLEDAI-2 K, SLEDAI-2 KG, and PGA was 11.9 ± 9.3, 16 ± 10.5, and 1.2 ± 0.8, respectively. The correlation between both the SLEDAI-2 KG (r: 0.96, p < 0.001) and PGA (r: 0.5, p < 0.001) and SLEDAI-2 K was statistically significant. The association's strength between both the SLEDAI-2 KG and PGA and SLEDAI-2 K declined among low activity-patients (SLEDAI-2 K < 6) [(r = 0,4; p < 0.001) (r = 0.2; p = 0.02), respectively], and the SLEDAI-2 KG and PGA were not associated in this subgroup (r: 0.07, p = 0.4). The agreement's strength between the SLEDAI-2 K and PISCOS-PGA was weak (kappa = 0.17, p < 0.001). The SLEDAI-2 K and SLEDAI-2 KG were comparable predictors for damage and the PGA was a weaker predictor. Conclusion: The SLEDAI-2 KG and PGA correlated significantly with the SLEDAI-2 K, yet the correlation's strength declined among low disease activity-patients. The SLEDAI-2 K and SLEDAI-2 KG were comparable predictors for damage.
- Subjects
SYSTEMIC lupus erythematosus; AGE of onset; DISEASE duration; PHYSICIANS; GLUCOCORTICOIDS
- Publication
Egyptian Journal of Internal Medicine, 2025, Vol 37, Issue 1, p1
- ISSN
1110-7782
- Publication type
Academic Journal
- DOI
10.1186/s43162-024-00389-3