We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association between weight-adjusted-waist index and the prevalence of gallstone disease in Minhang District, Shanghai: a cross-sectional study.
- Authors
Wang, Jian; Zheng, Zixuan; Tan, Hongyu; Wei, Shan; Gu, Yufeng; Cheng, Yingsheng; Xu, Chengyan; Wang, Wei
- Abstract
Background: Gallstone disease (GSD) is a common and costly health issue with a multifactorial etiology linked to obesity. The Weight-Adjusted-Waist Index (WWI) is a novel anthropometric measure that incorporates both weight and waist circumference, potentially offering a better assessment of GSD risk associated with adiposity. This study aims to evaluate the association between WWI and the prevalence of GSD. Methods: We conducted a cross-sectional study involving 19,426 participants divided into stone (n = 4,398) and non-stone (n = 15,028) groups based on ultrasound-confirmed GSD. WWI was calculated, and its association with GSD was analyzed using logistic regression models, adjusting for confounders such as age, gender, and comorbid conditions. Results: The prevalence of GSD was 22.6%. Participants with GSD had a higher mean age, a greater proportion of females, and higher Body Mass Index (BMI) compared to those without GSD. WWI was significantly higher in the stone group (p < 0.001). The prevalence of fatty liver was also higher in the stone group (p < 0.001). Laboratory findings indicated a subclinical inflammatory state in participants with GSD. The highest tertile of WWI was associated with an increased odds ratio for GSD (OR = 1.23, 95% CI: 1.13–1.35 in the fully adjusted model). WWI demonstrates superior predictive ability for gallstones compared to other obesity markers in obese populations. Conclusions: WWI is positively associated with the prevalence of GSD, independent of traditional risk factors. These findings suggest that WWI could serve as a practical screening tool to identify individuals at higher risk for GSD, emphasizing the need for targeted interventions to address central obesity.
- Subjects
GALLSTONES; BODY mass index; INFLAMMATION; MEDICAL sciences; PUBLIC health
- Publication
Journal of Health, Population & Nutrition, 2025, Vol 44, Issue 1, p1
- ISSN
1606-0997
- Publication type
Academic Journal
- DOI
10.1186/s41043-024-00731-z