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- Title
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
- Authors
Cong, Lin; Liu, Xiankun; Bai, Yiming; Qin, Qin; Zhao, Lili; Shi, Ying; Bai, Yunpeng; Guo, Zhigang
- Abstract
Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the global population. Pyroptosis and apoptosis, both caspase-mediated cell death mechanisms, play an essential role in the occurrence and progression of AS. The human pineal gland primarily produces melatonin (MT), an indoleamine hormone with powerful anti-oxidative, anti-pyroptotic, and anti-apoptotic properties. This study examined MT's anti-oxidative stress and anti-pyroptotic effects on human THP-1 macrophages treated with nicotine.
- Publication
Biological research, 2023, Vol 56, Issue 1, p62
- ISSN
0717-6287
- Publication type
Journal Article
- DOI
10.1186/s40659-023-00479-6