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- Title
Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia.
- Authors
Pereyra, Katherin; Las Heras, Alexandra; Toledo, Camilo; Díaz-Jara, Esteban; Iturriaga, Rodrigo; Del Rio, Rodrigo
- Abstract
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of chronic intermittent hypoxia (CIH), which has been linked to the development of sympathoexcitation and hypertension. Furthermore, it has been shown that CIH induced inflammation and neuronal hyperactivation in the nucleus of the solitary tract (NTS), a key brainstem region involved in sympathetic and cardiovascular regulation. Since several studies have proposed that NTS astrocytes may mediate neuroinflammation, we aimed to determine the potential contribution of NTS-astrocytes on the pathogenesis of CIH-induced hypertension.
- Publication
Biological research, 2023, Vol 56, Issue 1, p57
- ISSN
0717-6287
- Publication type
Journal Article
- DOI
10.1186/s40659-023-00463-0