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- Title
Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians.
- Authors
Piccardi, Margherita; Gentiluomo, Manuel; Bertoncini, Stefania; Pezzilli, Raffaele; Erőss, Bálint; Bunduc, Stefania; Uzunoglu, Faik G; Talar-Wojnarowska, Renata; Vanagas, Tomas; Sperti, Cosimo; Oliverius, Martin; Aoki, Mateus Nóbrega; Ermini, Stefano; Hussein, Tamás; Boggi, Ugo; Jamroziak, Krzysztof; Maiello, Evaristo; Morelli, Luca; Vodickova, Ludmila; Di Franco, Gregorio; Landi, Stefano; Szentesi, Andrea; Lovecek, Martin; Puzzono, Marta; Tavano, Francesca; van Laarhoven, Hanneke W M; Zerbi, Alessandro; Mohelnikova-Duchonova, Beatrice; Stocker, Hannah; Costello, Eithne; Capurso, Gabriele; Ginocchi, Laura; Lawlor, Rita T; Vanella, Giuseppe; Bazzocchi, Francesca; Izbicki, Jakob R; Latiano, Anna; Bueno-de-Mesquita, Bas; Ponz de Leon Pisani, Ruggero; Schöttker, Ben; Soucek, Pavel; Hegyi, Péter; Gazouli, Maria; Hackert, Thilo; Kupcinskas, Juozas; Poskiene, Lina; Tacelli, Matteo; Roth, Susanne; Carrara, Silvia; Perri, Francesco; Hlavac, Viktor; Theodoropoulos, George E; Busch, Olivier R; Mambrini, Andrea; van Eijck, Casper H J; Arcidiacono, Paolo; Scarpa, Aldo; Pasquali, Claudio; Basso, Daniela; Lucchesi, Maurizio; Milanetto, Anna Caterina; Neoptolemos, John P; Cavestro, Giulia Martina; Janciauskas, Dainius; Chen, Xuechen; Chammas, Roger; Goetz, Mara; Brenner, Hermann; Archibugi, Livia; Dannemann, Michael; Canzian, Federico; Tofanelli, Sergio; Campa, Daniele
- Abstract
The genomes of present-day non-Africans are composed of 1-3% of Neandertal-derived DNA as a consequence of admixture events between Neandertals and anatomically modern humans about 50-60 thousand years ago. Neandertal-introgressed single nucleotide polymorphisms (aSNPs) have been associated with modern human disease-related traits, which are risk factors for pancreatic ductal adenocarcinoma (PDAC), such as obesity, type 2 diabetes, and inflammation. In this study, we aimed at investigating the role of aSNPs in PDAC in three Eurasian populations.
- Publication
Biological research, 2023, Vol 56, Issue 1, p46
- ISSN
0717-6287
- Publication type
Journal Article
- DOI
10.1186/s40659-023-00457-y