We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Activation of a hypothalamus-habenula circuit by mechanical stimulation inhibits cocaine addiction-like behaviors.
- Authors
Jang, Han Byeol; Ahn, DanBi; Chang, Suchan; Kim, Hyung Kyu; Lee, Bong Hyo; Kim, Sang Chan; Steffensen, Scott C; Bills, Kyle B; Lee, Hubert; Kim, Hee Young
- Abstract
Mechanoreceptor activation modulates GABA neuron firing and dopamine (DA) release in the mesolimbic DA system, an area implicated in reward and substance abuse. The lateral habenula (LHb), the lateral hypothalamus (LH), and the mesolimbic DA system are not only reciprocally connected, but also involved in drug reward. We explored the effects of mechanical stimulation (MS) on cocaine addiction-like behaviors and the role of the LH-LHb circuit in the MS effects. MS was performed over ulnar nerve and the effects were evaluated by using drug seeking behaviors, optogenetics, chemogenetics, electrophysiology and immunohistochemistry.
- Publication
Biological research, 2023, Vol 56, Issue 1, p25
- ISSN
0717-6287
- Publication type
Journal Article
- DOI
10.1186/s40659-023-00440-7