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- Title
Review on plant antimicrobials: a mechanistic viewpoint.
- Authors
Khameneh, Bahman; Iranshahy, Milad; Soheili, Vahid; Fazly Bazzaz, Bibi Sedigheh
- Abstract
Microbial resistance to classical antibiotics and its rapid progression have raised serious concern in the treatment of infectious diseases. Recently, many studies have been directed towards finding promising solutions to overcome these problems. Phytochemicals have exerted potential antibacterial activities against sensitive and resistant pathogens via different mechanisms of action. In this review, we have summarized the main antibiotic resistance mechanisms of bacteria and also discussed how phytochemicals belonging to different chemical classes could reverse the antibiotic resistance. Next to containing direct antimicrobial activities, some of them have exerted in vitro synergistic effects when being combined with conventional antibiotics. Considering these facts, it could be stated that phytochemicals represent a valuable source of bioactive compounds with potent antimicrobial activities.
- Subjects
ANTI-infective agents; BIOACTIVE compounds; BIOCHEMICAL mechanism of action; COMMUNICABLE diseases; THERAPEUTICS
- Publication
Antimicrobial Resistance & Infection Control, 2019, Vol 8, Issue 1, pN.PAG
- ISSN
2047-2994
- Publication type
Academic Journal
- DOI
10.1186/s13756-019-0559-6