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- Title
Effect of steroid treatment on the diagnostic yield of baseline <sup>18</sup>f-fluorodeoxyglucose positron emission tomography in aggressive B cell lymphoma.
- Authors
Geiger, Karyn Revital; Pasvolsky, Oren; Berger, Tamar; Raanani, Pia; Shochat, Tzippy; Gurion, Ronit; Anati, Tamer; Groshar, David; Gafter-Gvili, Anat; Bernstine, Hanna
- Abstract
Aggressive B cell lymphoma often requires prompt steroid treatment, even before baseline 18f-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and definitive treatment, to alleviate symptoms or prevent organ damage. Since lymphoma is a steroid-sensitive malignancy, there are concerns that steroids might affect the results of FDG PET/CT and decrease its diagnostic yield. The aim of the current study was to evaluate the effect of steroids administered before baseline PET/CT on the maximum standardized uptake value (SUVmax) and additional PET/CT parameters. Retrospective review of the database in a tertiary medical center yielded 178 patients newly diagnosed with aggressive B cell lymphoma between January 2017 and May 2020 who had an available baseline FDG PET/CT scan. The cohort was divided into patients who received steroids before PET/CT (n = 47) and those who did not (n = 131), and the groups were compared for SUVmax and additional PET/CT parameters. The steroid-treated group had a higher disease stage and lactate dehydrogenase level compared to the steroid-naïve group, with a trend toward a higher international prognostic index. There was no significant between-group difference in SUVmax (P = 0.61). This finding remained consistent across steroid treatment durations and dosage regimens. Further evaluation revealed a significantly larger mean tumor volume and a trend toward a higher tumor metabolic burden in the steroid-treated group, yet no between-group difference in SUV mean or other PET/CT parameters. In this retrospective analysis of patients with aggressive B cell lymphoma, steroid prophase prior to baseline PET/CT did not decrease the diagnostic yield of the scan. However, further studies are required to fully appreciate the impact of steroids on PET CT parameters.
- Subjects
B cell lymphoma; POSITRON emission tomography; B cells; LACTATE dehydrogenase; COMPUTED tomography; TREATMENT effectiveness
- Publication
EJNMMI Research, 2022, Vol 12, Issue 1, p1
- ISSN
2191-219X
- Publication type
Academic Journal
- DOI
10.1186/s13550-022-00924-9