Results
Title

A novel partial volume correction method for accurate quantification of [<sup>18</sup>F] flortaucipir in the hippocampus.

Authors

Wolters, Emma E.; Golla, Sandeep S. V.; Timmers, Tessa; Ossenkoppele, Rik; van der Weijden, Chris W. J.; Scheltens, Philip; Schwarte, Lothar; Schuit, Robert C.; Windhorst, Albert D.; Barkhof, Frederik; Yaqub, Maqsood; Lammertsma, Adriaan A.; Boellaard, Ronald; van Berckel, Bart N. M.

Abstract

Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC).Methods: PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (VT), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used.Results: For controls, the correlation between hippocampal and CP VT was significantly reduced after using PVC along with an eroded VOI (r2 = 0.59, slope = 0.80 versus r2 = 0.15, slope = 0.15; difference: p T.

Subjects

FLUORODEOXYGLUCOSE F18; HIPPOCAMPUS physiology; CHOROID plexus; POSITRON emission tomography; STATISTICAL correlation; PHYSIOLOGY

Publication

EJNMMI Research, 2018, Vol 8, Issue 1, p1

ISSN

2191-219X

Publication type

Academic Journal

DOI

10.1186/s13550-018-0432-2