Works matching DE "BIOISOSTERES"

Results: 112

Fragrances of Cage Bicyclic Benzene Bioisosteres.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 22, p. 1, doi. 10.1002/chem.202404716

By:

O'Donohue, Grace R. M.;
Chow, Sharon;
Houston, Sevan D.;
Nguyen, Thoa T. L.;
Paul Savage, G.;
Smyth, Heather E.;
Williams, Craig M.

Publication type:

Article

Enzymatic Synthesis of Saturated Bioisosteres of Ortho‐Substituted Benzenes by Artificial Photoenzyme.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 20, p. 1, doi. 10.1002/chem.202404519

By:

Bai, Yuting;
Sheng, Yuhui;
Fu, Yi;
Zhou, Zhi;
Wu, Jing

Publication type:

Article

Physicochemical and Biological Evaluation of gem‐Difluorinated Saturated Oxygen Heterocycles as Bioisosteres for Drug Discovery.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 10, p. 1, doi. 10.1002/chem.202404390

By:

Melnykov, Kostiantyn P.;
Liashuk, Oleksandr S.;
Holovach, Serhii;
Shatnia, Valeriia;
Horbenko, Artur;
Lesyk, Dmytro;
Melnyk, Varvara;
Skrypnik, Daniil;
Beshtynarska, Anna;
Borysko, Petro;
Viniichuk, Oleksandr;
Grygorenko, Oleksandr O.

Publication type:

Article

Double Strain‐Release (3+3)‐Cycloaddition: Lewis Acid Catalyzed Reaction of Bicyclobutane Carboxylates and Aziridines.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 9, p. 1, doi. 10.1002/chem.202404099

By:

George, Malini;
Mindner, Jasper;
Wittmer, Silas;
Knyazev, Daniil A.;
Werz, Daniel B.

Publication type:

Article

3,3‐Difluorooxetane–A Versatile Functional Group for Bioisosteric Replacements in Drug Discovery.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 72, p. 1, doi. 10.1002/chem.202403277

By:

Liashuk, Oleksandr S.;
Fedinchyk, Anastasiya;
Melnykov, Kostiantyn P.;
Herasymchuk, Maksym;
Alieksieieva, Diana;
Lesyk, Dmytro;
Bas, Yuliia P.;
Keda, Tetiana Ye.;
Yatsymyrskiy, Andriy V.;
Holota, Yuliia;
Borysko, Petro;
Yarmolchuk, Volodymyr S.;
Grygorenko, Oleksandr O.

Publication type:

Article

Organometallic Bridge Diversification of Bicyclo[1.1.1]pentanes.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 12, p. 1, doi. 10.1002/chem.202304070

By:

Anderson, Joseph M.;
Poole, Darren L.;
Cook, Gemma C.;
Murphy, John A.;
Measom, Nicholas D.

Publication type:

Article

Scaffold Editing of Cubanes into Homocubanes, Homocuneanes via Cuneanes.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 9, p. 1, doi. 10.1002/chem.202303063

By:

Takebe, Hiyori;
Matsubara, Seijiro

Publication type:

Article

Antioxidant properties in a non-polar environment of difluoromethyl bioisosteres of methyl hydroxycinnamates.

Published in:

Journal of Pharmacy & Pharmacology, 2016, v. 68, n. 2, p. 233, doi. 10.1111/jphp.12507

By:

Martínez, Mario D.;
Luna, Lorena;
Tesio, Alvaro Y.;
Feresin, Gabriela E.;
Durán, Fernando J.;
Burton, Gerardo

Publication type:

Article

Agrochemical lead optimization by scaffold hopping.

Published in:

Pest Management Science, 2018, v. 74, n. 2, p. 282, doi. 10.1002/ps.4755

By:

Lamberth, Clemens

Publication type:

Article

Heterocyclic chemistry in crop protection.

Published in:

Pest Management Science, 2013, v. 69, n. 10, p. 1106, doi. 10.1002/ps.3615

By:

Lamberth, Clemens

Publication type:

Article

Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group.

Published in:

Communications Chemistry, 2020, v. 3, n. 1, p. N.PAG, doi. 10.1038/s42004-020-00368-z

By:

De Biase, Daniela;
Cappadocio, Francesca;
Pennacchietti, Eugenia;
Giovannercole, Fabio;
Coluccia, Antonio;
Vepsäläinen, Jouko;
Khomutov, Alex

Publication type:

Article

Reaction Paradigms that Leverage Cycloaddition and Ring Strain to Construction Bicyclic Aryl Bioisosteres from Bicyclo[1.1.0]butanes.

Published in:

Asian Journal of Organic Chemistry, 2024, v. 13, n. 5, p. 1, doi. 10.1002/ajoc.202400045

By:

Sujansky, Stephen J.;
Ma, Xiaoshen

Publication type:

Article

Input of Isosteric and Bioisosteric Approach in Drug Design.

Published in:

Journal of the Chemical Society of Pakistan, 2014, v. 36, n. 1, p. 150

By:

Ali, Gowhar;
Subhan, Fazal;
Ul Islam, Nazar;
Khan, Inamullah;
Rauf, Khalid;
Samiullah;
Abbas, Muzaffar;
Rauf, Abdur

Publication type:

Article

Visualizing GABA transporters in vivo: an overview of reported radioligands and future directions.

Published in:

EJNMMI Research, 2023, v. 13, n. 1, p. 1, doi. 10.1186/s13550-023-00992-5

By:

Knippenberg, Niels;
Bauwens, Matthias;
Schijns, Olaf;
Hoogland, Govert;
Florea, Alexandru;
Rijkers, Kim;
Cleij, Thomas J.;
Eersels, Kasper;
van Grinsven, Bart;
Diliën, Hanne

Publication type:

Article

Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid.

Published in:

Psychopharmacology, 2014, v. 231, n. 17, p. 3517, doi. 10.1007/s00213-014-3494-5

By:

Hogenkamp, Derk;
Tran, Minhtam;
Yoshimura, Ryan;
Johnstone, Timothy;
Kanner, Richard;
Gee, Kelvin

Publication type:

Article

Synthesis and biological activity of fused furo[2,3-d]pyrimidinone derivatives as analgesic and antitumor agents.

Published in:

Research on Chemical Intermediates, 2016, v. 42, n. 2, p. 939, doi. 10.1007/s11164-015-2064-8

By:

Li, Qing;
Chen, Yong-Mei;
Hu, Yang-Gen;
Luo, Xin;
Ko, Joshua;
Cheung, Chi

Publication type:

Article

Outstanding effect of the conformational restriction of isoquinolines: hints for the development of optimized antimicrobial agents.

Published in:

Research on Chemical Intermediates, 2013, v. 39, n. 7, p. 2955, doi. 10.1007/s11164-012-0808-2

By:

Ozcelik, Berrin;
Sheikh, Javed;
Orhan, Ilkay;
Juneja, Harjeet;
Bennani, Brahim;
Kerbal, Abdelali;
Cavalcanti, S.;
Leite, Ana;
Ben Hadda, Taibi

Publication type:

Article

C−F bond activation enables synthesis of aryl difluoromethyl bicyclopentanes as benzophenone-type bioisosteres.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-023-44653-6

By:

Chen, Mingshuo;
Cui, Yuang;
Chen, Xiaoping;
Shang, Rui;
Zhang, Xiaheng

Publication type:

Article

2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41298-3

By:

Levterov, Vadym V.;
Panasiuk, Yaroslav;
Sahun, Kateryna;
Stashkevych, Oleksandr;
Badlo, Valentyn;
Shablykin, Oleh;
Sadkova, Iryna;
Bortnichuk, Lina;
Klymenko-Ulianov, Oleksii;
Holota, Yuliia;
Lachmann, Leonid;
Borysko, Petro;
Horbatok, Kateryna;
Bodenchuk, Iryna;
Bas, Yuliia;
Dudenko, Dmytro;
Mykhailiuk, Pavel K.

Publication type:

Article

Probing the Orthosteric Binding Site of GABA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres.

Published in:

Neurochemical Research, 2014, v. 39, n. 6, p. 1005, doi. 10.1007/s11064-013-1226-6

By:

Petersen, Jette;
Bergmann, Rikke;
Krogsgaard-Larsen, Povl;
Balle, Thomas;
Frølund, Bente

Publication type:

Article

Synthesis of Aminobisphosphinates through a Cascade Reaction between Hypophosphorous Acid and Bis(trimethylsilyl)imidates Mediated by ZnI 2.

Published in:

Molecules, 2023, v. 28, n. 17, p. 6226, doi. 10.3390/molecules28176226

By:

Ayadi, Nouha;
Descamps, Aurélie;
Legigan, Thibaut;
Dussart-Gautheret, Jade;
Monteil, Maelle;
Migianu-Griffoni, Evelyne;
Ben Ayed, Taïcir;
Deschamp, Julia;
Lecouvey, Marc

Publication type:

Article

Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade.

Published in:

Molecules, 2022, v. 27, n. 9, p. 2709, doi. 10.3390/molecules27092709

By:

El-Masry, Rana M.;
Kadry, Hanan H.;
Taher, Azza T.;
Abou-Seri, Sahar M.

Publication type:

Article

Effect of S–Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel N -acylhydrazone Derivatives at the Adenosine A 2A Receptor.

Published in:

Molecules, 2021, v. 26, n. 23, p. 7364, doi. 10.3390/molecules26237364

By:

Pedreira, Júlia Galvez Bulhões;
Silva, Rafaela Ribeiro;
Noël, François G.;
Barreiro, Eliezer J.

Publication type:

Article

Design, Synthesis, and In Silico Multitarget Pharmacological Simulations of Acid Bioisosteres with a Validated In Vivo Antihyperglycemic Effect.

Published in:

Molecules, 2021, v. 26, n. 4, p. 799, doi. 10.3390/molecules26040799

By:

Domínguez-Mendoza, Elix Alberto;
Galván-Ciprés, Yelzyn;
Martínez-Miranda, Josué;
Miranda-González, Cristian;
Colín-Lozano, Blanca;
Hernández-Núñez, Emanuel;
Hernández-Bolio, Gloria I.;
Palomino-Hernández, Oscar;
Navarrete-Vazquez, Gabriel;
Maccari, Rosanna;
Ottana, Rosaria

Publication type:

Article

Indole-Containing Phytoalexin-Based Bioisosteres as Antifungals: In Vitro and In Silico Evaluation against Fusarium oxysporum.

Published in:

Molecules, 2020, v. 25, n. 1, p. 45, doi. 10.3390/molecules25010045

By:

Angarita-Rodríguez, Andrea;
Quiroga, Diego;
Coy-Barrera, Ericsson;
Daglia, Maria;
Carradori, Simone;
Vitalone, Annabella

Publication type:

Article

Ag/Pyridine Co-Mediated Oxidative Arylthiocyanation of Activated Alkenes.

Published in:

Molecules, 2018, v. 23, n. 10, p. 2727, doi. 10.3390/molecules23102727

By:

Kong, De-Long;
Du, Jian-Xun;
Chu, Wei-Ming;
Ma, Chun-Ying;
Tao, Jia-Yi;
Feng, Wen-Hua

Publication type:

Article

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency.

Published in:

Molecules, 2018, v. 23, n. 8, p. 1940, doi. 10.3390/molecules23081940

By:

Narayan, Mahesh;
Meuser, Megan E.;
Rashad, Adel A.;
Cocklin, Simon;
Murphy, Michael B.

Publication type:

Article

Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties.

Published in:

Journal of Chemistry, 2022, p. 1, doi. 10.1155/2022/2164558

By:

Bredael, Kato;
Geurs, Silke;
Clarisse, Dorien;
De Bosscher, Karolien;
D'hooghe, Matthias

Publication type:

Article

Isocyanide–Based Multicomponent Reactions Coupled One–Pot Process: Efficient Tools to Diversity–Oriented Synthesis of Structural Peptidomimetics.

Published in:

ChemPlusChem, 2024, v. 89, n. 6, p. 1, doi. 10.1002/cplu.202300633

By:

Kaveti, Bhavna;
Rentería‐Gómez, Manuel A.;
Corona‐Díaz, Alejandro;
Pharande, Shrikant G.;
Rentería‐Gómez, Ángel;
Gámez‐Montaño, Rocío

Publication type:

Article

Acceleration of Binding Site Comparisons by Graph Partitioning.

Published in:

Molecular Informatics, 2015, v. 34, n. 8, p. 550, doi. 10.1002/minf.201500028

By:

Krotzky, Timo;
Klebe, Gerhard

Publication type:

Article

Bioisosteres and Scaffold Hopping in Medicinal Chemistry.

Published in:

Molecular Informatics, 2014, v. 33, n. 6/7, p. 458, doi. 10.1002/minf.201400037

By:

Brown, Nathan

Publication type:

Article

Difluoromethyl Nitrile Oxide (CF2HCNO): A Neglected Chemical Reagent.

Published in:

European Journal of Organic Chemistry, 2017, v. 2017, n. 27, p. 3935, doi. 10.1002/ejoc.201700764

By:

Khutorianskyi, Andrii;
Chalyk, Bohdan;
Borysko, Petro;
Kondratiuk, Anna;
Mykhailiuk, Pavel K.

Publication type:

Article

Synthesis and Biological Evaluation of Migrastatin Macrotriazoles.

Published in:

European Journal of Organic Chemistry, 2017, v. 2017, n. 1, p. 60, doi. 10.1002/ejoc.201600988

By:

Gabba, Adele;
Robakiewicz, Stefania;
Taciak, Bartłomiej;
Ulewicz, Katarzyna;
Broggini, Gianluigi;
Rastelli, Giulio;
Krol, Magadalena;
Murphy, Paul V.;
Passarella, Daniele

Publication type:

Article

4′-Selenonucleosides as Next-Generation Nucleosides.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 28, p. 6115, doi. 10.1002/ejoc.201500429

By:

Sahu, Pramod K.;
Naik, Siddhi D.;
Yu, Jinha;
Jeong, Lak Shin

Publication type:

Article

Synthesis of [(1,2,3-Triazol-1-yl)methyl]boronic Acids Through Click Chemistry: Easy Access to a Potential Scaffold for Protease Inhibitors.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 5, p. 1075, doi. 10.1002/ejoc.201403408

By:

Romagnoli, Chiara;
Caselli, Emilia;
Prati, Fabio

Publication type:

Article

Role of Side-Chain Bioisosteres in Determining the Binding Affinity of Click Chemistry Derived RGD Peptidomimetics to αvβ3 Integrin.

Published in:

European Journal of Organic Chemistry, 2014, v. 2014, n. 34, p. 7595, doi. 10.1002/ejoc.201403129

By:

Fabbrizzi, Pierangelo;
Menchi, Gloria;
Raspanti, Silvia;
Guarna, Antonio;
Trabocchi, Andrea

Publication type:

Article

Synthesis of 1,2,3‐Triazole and Pyrazole Analogues as Bioisosteres of Biphenyl‐Neolignans.

Published in:

Bulletin of the Korean Chemical Society, 2018, v. 39, n. 1, p. 126, doi. 10.1002/bkcs.11352

By:

Sun, Wei;
Kim, Taek‐Soo;
Choi, Nam Song;
Seo, Seung‐Yong

Publication type:

Article

Annotation and curation of uncharacterized proteins- challenges.

Published in:

Frontiers in Genetics, 2015, v. 6, p. 1, doi. 10.3389/fgene.2015.00119

By:

Ijaq, Johny;
Chandrasekharan, Mohanalatha;
Poddar, Rajdeep;
Bethi, Neeraja;
Sundararajan, Vijayaraghava S.

Publication type:

Article

Context-dependent similarity analysis of analogue series for structure–activity relationship transfer based on a concept from natural language processing.

Published in:

Journal of Cheminformatics, 2025, v. 17, n. 1, p. 1, doi. 10.1186/s13321-025-00951-3

By:

Yoshimori, Atsushi;
Bajorath, Jürgen

Publication type:

Article

Palladium-Catalyzed Fluorination of Cyclic Vinyl Triflates: Effect of TESCF3 as an Additive.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 50, p. 15559, doi. 10.1002/anie.201608927

By:

Ye, Yuxuan;
Takada, Takashi;
Buchwald, Stephen L.

Publication type:

Article

Bioisosteric Exchange of C.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 12, p. 4049, doi. 10.1002/anie.201511672

By:

Krautwald, Simon;
Nilewski, Christian;
Mori, Mihoko;
Shiomi, Kazuro;
Ōmura, Satoshi;
Carreira, Erick M.

Publication type:

Article

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 11, p. 3580, doi. 10.1002/anie.201510675

By:

Chalmers, Benjamin A.;
Xing, Hui;
Houston, Sevan;
Stok, Jeanette E.;
Bernhardt, Paul V.;
De Voss, James J.;
Williams, Craig M.;
Clark, Charlotte;
Cooper, Helen M.;
Ghassabian, Sussan;
Kuo, Andy;
Smith, Maree T.;
Littler, Stuart W.;
Tsanaktsidis, John;
Savage, G. Paul;
Cao, Benjamin;
Reitsma, Andrea;
Nilsson, Susan K.;
Winkler, David A.;
Murray, Cody-Ellen P.

Publication type:

Article

Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 11, p. n/a, doi. 10.1002/anie.201681161

By:

Chalmers, Benjamin A.;
Xing, Hui;
Houston, Sevan;
Stok, Jeanette E.;
Bernhardt, Paul V.;
De Voss, James J.;
Williams, Craig M.;
Clark, Charlotte;
Cooper, Helen M.;
Ghassabian, Sussan;
Kuo, Andy;
Smith, Maree T.;
Littler, Stuart W.;
Tsanaktsidis, John;
Savage, G. Paul;
Cao, Benjamin;
Reitsma, Andrea;
Nilsson, Susan K.;
Winkler, David A.;
Murray, Cody-Ellen P.

Publication type:

Article

Facile Synthesis and Properties of 2-λ5-Phosphaquinolines and 2-λ5-Phosphaquinolin-2-ones.

Published in:

Angewandte Chemie International Edition, 2015, v. 54, n. 45, p. 13318, doi. 10.1002/anie.201507696

By:

Vonnegut, Chris L.;
Shonkwiler, Airlia M.;
Khalifa, Muhammad M.;
Zakharov, Lev N.;
Johnson, Darren W.;
Haley, Michael M.

Publication type:

Article

Simple Sulfinate Synthesis Enables CH Trifluoromethylcyclopropanation.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 37, p. 9851, doi. 10.1002/anie.201406622

By:

Gianatassio, Ryan;
Kawamura, Shuhei;
Eprile, Cecil L;
Foo, Klement;
Ge, Jason;
Burns, Aaron C.;
Collins, Michael R.;
Baran, Phil S.

Publication type:

Article

Melatonin and its bioisosteres as potential therapeutic agents for the treatment of retinopathy of prematurity.

Published in:

Chemical Biology & Drug Design, 2024, v. 103, n. 3, p. 1, doi. 10.1111/cbdd.14504

By:

Osipova, N. A.;
Panova, A. Y.;
Efremov, A. M.;
Lozinskaya, N. A.;
Beznos, O. V.;
Katargina, L. A.

Publication type:

Article

Bioisosteric modification on benzylidene‐carbonyl compounds improved the drug‐likeness and maintained the antifungal activity against Sporothrix brasiliensis.

Published in:

Chemical Biology & Drug Design, 2022, v. 99, n. 3, p. 391, doi. 10.1111/cbdd.13994

By:

Waller, Stefanie Bressan;
Cleff, Marlete Brum;
Ripoll, Márcia Kutscher;
Meireles, Mário Carlos Araújo;
Ferrarini, Márcio;
Varela, Marina Themoteo;
Fernandes, João Paulo S.

Publication type:

Article

Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening.

Published in:

Chemical Biology & Drug Design, 2016, v. 88, n. 2, p. 178, doi. 10.1111/cbdd.12744

By:

Zhang, Wei;
Zhai, Ling;
Lu, Wenyan;
Boohaker, Rebecca J.;
Padmalayam, Indira;
Li, Yonghe

Publication type:

Article

Sirtuins are Unaffected by PARP Inhibitors Containing Planar Nicotinamide Bioisosteres.

Published in:

Chemical Biology & Drug Design, 2016, v. 87, n. 3, p. 478, doi. 10.1111/cbdd.12680

By:

Ekblad, Torun;
Schüler, Herwig

Publication type:

Article

Synthesis and fungicidal activities of positional isomers of the N-thienylcarboxamide.

Published in:

Journal of Pesticide Science, 2021, v. 46, n. 2, p. 229, doi. 10.1584/jpestics.D20-062

By:

Hiroyuki Katsuta;
Tomomi Shirakawa;
Miyuki Kawashima;
Shinichi Banba

Publication type:

Article