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- Title
Research advances in the construction of stem cell-derived ovarian organoids.
- Authors
Zhang, Tianyue; Zhang, Mengtong; Zhang, Sichen; Wang, Shaowei
- Abstract
Ovarian organoids are essential in female reproductive medicine, enhancing our understanding of ovarian diseases and improving treatments, which benefits women's health. Constructing ovarian organoids involves two main processes: differentiating induced pluripotent stem cells (iPSCs) into germ and ovarian somatic cells to restore ovarian function and using extracellular matrix (ECM) to create a suitable ovarian microenvironment and scaffold. Although the technology is still in its early stages, future advancements will likely involve integrating high-throughput analysis, 3D-printed scaffolds, and efficient iPSC induction, driving progress in reproductive and regenerative medicine.
- Subjects
PLURIPOTENT stem cells; EXTRACELLULAR matrix; SOMATIC cells; REPRODUCTIVE health; MEDICAL sciences
- Publication
Stem Cell Research & Therapy, 2024, Vol 15, Issue 1, p1
- ISSN
1757-6512
- Publication type
Academic Journal
- DOI
10.1186/s13287-024-04122-3