Research advances in the construction of stem cell-derived ovarian organoids.

Zhang, Tianyue; Zhang, Mengtong; Zhang, Sichen; Wang, Shaowei

Ovarian organoids are essential in female reproductive medicine, enhancing our understanding of ovarian diseases and improving treatments, which benefits women's health. Constructing ovarian organoids involves two main processes: differentiating induced pluripotent stem cells (iPSCs) into germ and ovarian somatic cells to restore ovarian function and using extracellular matrix (ECM) to create a suitable ovarian microenvironment and scaffold. Although the technology is still in its early stages, future advancements will likely involve integrating high-throughput analysis, 3D-printed scaffolds, and efficient iPSC induction, driving progress in reproductive and regenerative medicine.

PLURIPOTENT stem cells; EXTRACELLULAR matrix; SOMATIC cells; REPRODUCTIVE health; MEDICAL sciences

Stem Cell Research & Therapy, 2024, Vol 15, Issue 1, p1

1757-6512

Academic Journal

10.1186/s13287-024-04122-3