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Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer.
- Published in:
- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01407-3
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- Article
Efficacy and safety of novel multiple-chain DAP-CAR-T cells targeting mesothelin in ovarian cancer and mesothelioma: a single-arm, open-label and first-in-human study.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01405-5
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- Article
Neoantigen DNA vaccines are safe, feasible, and induce neoantigen-specific immune responses in triple-negative breast cancer patients.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01388-3
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pVACview: an interactive visualization tool for efficient neoantigen prioritization and selection.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01384-7
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- Article
Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01404-6
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- Article
KleTy: integrated typing scheme for core genome and plasmids reveals repeated emergence of multi-drug resistant epidemic lineages in Klebsiella worldwide.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01399-0
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- Article
Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01404-6
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- Article
KleTy: integrated typing scheme for core genome and plasmids reveals repeated emergence of multi-drug resistant epidemic lineages in Klebsiella worldwide.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01399-0
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- Article
Exploring multi-omics and clinical characteristics linked to accelerated biological aging in Asian women of reproductive age: insights from the S-PRESTO study.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01403-7
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- Article
Curating genomic disease-gene relationships with Gene2Phenotype (G2P).
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01398-1
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- Article
Circular RNA landscape in extracellular vesicles from human biofluids.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01400-w
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- Article
Cardiomyopathies in 100,000 genomes project: interval evaluation improves diagnostic yield and informs strategies for ongoing gene discovery.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01390-9
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- Article
Developmental-status-aware transcriptional decomposition establishes a cell state panorama of human cancers.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01393-6
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- Article
Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01395-4
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- Article
Identification of diagnostic candidates in Mendelian disorders using an RNA sequencing-centric approach.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01381-w
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- Article
A genome-based survey of invasive pneumococci in Norway over four decades reveals lineage-specific responses to vaccination.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01396-3
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- Article
Applicability of epigenetic age models to next-generation methylation arrays.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01387-4
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- Article
Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01326-3
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- Article
Combining optical genome mapping and RNA-seq for structural variants detection and interpretation in unsolved neurodevelopmental disorders.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01382-9
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- Article
Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01397-2
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Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01394-5
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- Article
Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01385-6
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- Article
A validated heart-specific model for splice-disrupting variants in childhood heart disease.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01383-8
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- Article
DNA demethylation triggers cell free DNA release in colorectal cancer cells.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01386-5
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- Article
Nanopore sequencing with unique molecular identifiers enables accurate mutation analysis and haplotyping in the complex lipoprotein(a) KIV-2 VNTR.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01391-8
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- Article
High density genomic surveillance and risk profiling of clinical Listeria monocytogenes subtypes in Germany.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01389-2
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- Article
Machine learning integrative approaches to advance computational immunology.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01350-3
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- Article
Chromatin conformation capture in the clinic: 4C-seq/HiC distinguishes pathogenic from neutral duplications at the GPR101 locus.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01378-5
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- Article
Colorectal cancer microbiome programs DNA methylation of host cells by affecting methyl donor metabolism.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01344-1
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- Article
Knockout mice with pituitary malformations help identify human cases of hypopituitarism.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01347-y
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- Article
Optimizing clinico-genomic disease prediction across ancestries: a machine learning strategy with Pareto improvement.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01345-0
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- Article
Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01380-x
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- Article
Long-term persistence of diverse clones shapes the transmission landscape of invasive Listeria monocytogenes.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01379-4
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- Article
Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01371-y
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- Article
Genome Tunisia Project: paving the way for precision medicine in North Africa.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01365-w
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- Article
Ancestry-aligned polygenic scores combined with conventional risk factors improve prediction of cardiometabolic outcomes in African populations.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01377-6
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- Article
The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01370-z
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- Article
Gut microbiome structure and function in asymptomatic diverticulosis.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01374-9
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- Article
Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01376-7
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- Article
Identification of tumor rejection antigens and the immunologic landscape of medulloblastoma.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01363-y
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- Article
Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01354-z
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- Article
Laterality, heterotaxy, and isolated congenital heart defects: The genetic basis of the segmental nature of the heart.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01375-8
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- Article
Association of genetic ancestry with molecular tumor profiles in colorectal cancer.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01373-w
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- Article
Spatial multiomics reveals a subpopulation of fibroblasts associated with cancer stemness in human hepatocellular carcinoma.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01367-8
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- Article
ENU-based dominant genetic screen identifies contractile and neuronal gene mutations in congenital heart disease.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01372-x
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- Article
The genetics and epidemiology of N- and O-immunoglobulin A glycomics.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01369-6
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- Article
Microglial heterogeneity in the ischemic stroke mouse brain of both sexes.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01368-7
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- Article
Meta-analysis identifies common gut microbiota associated with multiple sclerosis.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01364-x
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- Article
Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01366-9
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- Article
Prostate cancers with distinct transcriptional programs in Black and White men.
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- Genome Medicine, 2024, v. 16, n. 1, p. 1, doi. 10.1186/s13073-024-01361-0
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- Article