Works matching DE "DRUG target"

Results: 5000

Identification of metabolic biomarkers and therapeutic targets in the thymoma-associated myasthenia gravis treated with methylprednisolone.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02700-2

By:

Gu, Shanshan;
Wang, Xu;
Yang, Hongxia;
Wang, Yaxuan;
Yan, Congya;
Lin, Xiaoting;
Liu, Peng;
Liu, Lu;
Meng, Li;
Qi, Guoyan

Publication type:

Article

Post-translational modifications and the reprogramming of tumor metabolism.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02674-1

By:

Hu, Yuqing;
Xu, Wenxia;
Chen, Lin

Publication type:

Article

IGLC1 is an independent prognostic marker and potent therapeutic target in osteosarcoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02653-6

By:

Wu, Zhenjie;
Xie, Xinlian;
Shi, Guangfu;
Ning, Kebin;
Zhao, Jinmin

Publication type:

Article

The role and diagnostic value of deregulated miRNAs in cervical cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02744-4

By:

Parvizi, Masoumeh;
Vaezi, Maryam;
Jeddi, Farhad;
Bakhshandeh, Masoumeh;
Eghdam-Zamiri, Reza;
Mobaraki-Asl, Noushin;
Esmati, Ebrahim;
Karimi, Abbas

Publication type:

Article

Reciprocal regulation between m6 A modifications and non-coding RNAs: emerging roles in cancer therapeutic resistance.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02641-w

By:

Fan, Dan;
Shang, Yan;
Cong, Yating;
Jiao, Yanlin;
Li, Na;
Zhao, Hailong

Publication type:

Article

Unraveling drug resistance mechanisms in testicular cancer through immune cell phenotypes: a bidirectional Mendelian randomization analysis revealing novel therapeutic targets.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02757-z

By:

Xiao, Lin;
Wu, Tianen

Publication type:

Article

Deciphering Dysfunctional Regulatory T Cells in Atopic Dermatitis.

Published in:

Allergy, 2025, v. 80, n. 5, p. 1473, doi. 10.1111/all.16439

By:

Kang, Seong‐Jun;
Gong, Jeong‐Ryeol;
Jin, Seon‐Pil;
Oh, Jin‐Mi;
Jin, Hyunjin;
Lee, Yuji;
Moon, Yewon;
Kim, Dongjun;
Nam, Hyo Jeong;
Choi, Hyun Seung;
Hwang, Sanha;
Huh, Yun Jung;
Han, Kyung Yeon;
Moon, Jihwan;
Chung, Jongsuk;
Park, Woong‐Yang;
Park, Chung‐Gyu;
Kim, Hyun Je;
Kim, Jeong Eun

Publication type:

Article

MiR‐10b‐5p alleviates Th2 inflammatory response by targeting SHP2 phosphatase in allergic rhinitis.

Published in:

Allergy, 2025, v. 80, n. 5, p. 1517, doi. 10.1111/all.16293

By:

Li, Yumei;
Zhao, Xiangkun;
Liu, Zhen;
Lu, Congxian;
Wang, Yaqi;
Liu, Jiahui;
Mou, Yakui;
Zhang, Yu;
Li, Bing;
Song, Xicheng

Publication type:

Article

Integrated Transcriptomic and Metabolomic Analysis of Rat PASMCs Reveals the Underlying Mechanism for Pulmonary Arterial Hypertension.

Published in:

American Journal of Hypertension, 2025, v. 38, n. 6, p. 398, doi. 10.1093/ajh/hpaf015

By:

Hou, Jie;
Liu, Ke;
Zhang, Meng-Jie;
Xu, Xiao-He;
Meng, Fang-Fang;
Wang, Chen-Chen;
Yang, Ou;
Zhao, Lu-Ling;
Wang, Meng-Wei;
Zhou, Yun-Feng;
Pang, Xiao-Bin;
He, Yang-Yang;
Kou, Jie-Jian;
Xie, Xin-Mei;
Zhang, Hong-Da;
Shi, Jun-Zhuo

Publication type:

Article

IL‐24 for bullous pemphigoid severity: A case–control study.

Published in:

Journal of the European Academy of Dermatology & Venereology, 2025, v. 39, n. 6, p. e511, doi. 10.1111/jdv.20467

By:

Ran, Yutong;
Peng, Xueting;
Xia, Yumin;
Liu, Yale

Publication type:

Article

Unraveling the artificial intelligence role in drug discovery and pharmaceutical product design: an opportunity and challenges.

Published in:

Discover Artificial Intelligence, 2025, v. 5, n. 1, p. 1, doi. 10.1007/s44163-025-00330-9

By:

Pandey, Bhakti Sudha;
Durgapal, Sumit;
Kumar, Prashant;
Kukreti, Gauree;
Jain, Anjali;
Paliwal, Girish;
Kumar, Manish

Publication type:

Article

STUDY OF BCL2 EXPRESSION IN ENDOMETRIAL HYPERPLASIA AND ENDOMETRIAL CARCINOMA.

Published in:

Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2025, v. 16, n. 3, p. 280

By:

V. G., Neenu;
Glaxon, Jinu Abraham;
Suseelan, Aditi;
Chandramohan, Aswathy;
George, Vivek

Publication type:

Article

Study on the Chemical Composition, Biological Activity, and Mechanism of Intervention in Erectile Dysfunction of Healthy Snow Lotus Wine.

Published in:

Food Science & Nutrition, 2025, v. 13, n. 5, p. 1, doi. 10.1002/fsn3.70279

By:

Yang, Bohan;
Tao, Siyu;
Wang, Linyang;
Yao, Yanna;
Wang, Xinyu;
Tian, Shuge

Publication type:

Article

Advances in the Study of Metabolic Reprogramming in Gastric Cancer.

Published in:

Cancer Medicine, 2025, v. 14, n. 10, p. 1, doi. 10.1002/cam4.70948

By:

Rong, Yu;
Teng, Yuanyin;
Zhou, Xiaoying

Publication type:

Article

Integrative transcriptomic-physiological analysis deciphers nitrogen-mediated carbon reallocation balancing growth and flavonoid metabolism in Epimedium pubescens.

Published in:

Frontiers in Plant Science, 2025, p. 1, doi. 10.3389/fpls.2025.1539445

By:

Liu, Shangnian;
An, Xiaojing;
Xu, Chaoqun;
He, Dongmei;
Li, Xianen;
Chen, Caixia;
Guo, Baolin;
Xu, De;
Huang, Juan

Publication type:

Article

Investigation of Fructus sophorae extract 's therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1571976

By:

Zheng, Jiarui;
Wang, Weiming;
Song, Wenting;
Zhang, Yehao;
Yao, Mingjiang;
Wang, Guangrui;
Huang, Zishan;
Li, Feng;
Ren, Junguo;
Lin, Li;
Fan, Xiaodi;
Liu, Jianxun

Publication type:

Article

A comprehensive update on the application of high-throughput fluorescence imaging for novel drug discovery.

Published in:

Expert Opinion on Drug Discovery, 2025, v. 20, n. 6, p. 785, doi. 10.1080/17460441.2025.2499123

By:

Ronzetti, Michael;
Simeonov, Anton

Publication type:

Article

Voltage‐Gated Ca<sup>2+</sup> Channels in Prefrontal Parvalbumin Neurons Are Essential for Stress‐Induced Depression.

Published in:

Acta Physiologica, 2025, v. 241, n. 6, p. 1, doi. 10.1111/apha.70053

By:

Lin, Katrina;
Coutellier, Laurence

Publication type:

Article

Targeting Inflammation in Type 2 Diabetes: The Emerging Role of Decorin.

Published in:

Acta Physiologica, 2025, v. 241, n. 6, p. 1, doi. 10.1111/apha.70049

By:

Sharmine, Shayla;
Ghila, Luiza

Publication type:

Article

Dysfunction of a lepidopteran conserved gene, BmBLOC1S6, causes a translucent larval integument in the silkworm, Bombyx mori.

Published in:

Pest Management Science, 2025, v. 81, n. 6, p. 2957, doi. 10.1002/ps.8664

By:

Sun, Tao;
Song, Jiangbo;
Luo, Jingzhi;
Jiang, Yu;
Tan, Duan;
Zhou, Lei;
Wu, Wentao;
Han, Minjin;
Hu, Hai;
Tong, Xiaoling;
Lu, Cheng;
Dai, Fangyin

Publication type:

Article

Foliar spray double‐stranded RNA targeting HvIAP1 induces high larval and adult mortality in Henosepilachna vigintioctopunctata.

Published in:

Pest Management Science, 2025, v. 81, n. 6, p. 2981, doi. 10.1002/ps.8667

By:

Ji, Tianliang;
Li, Langcheng;
Zhu, Xin;
Wang, Guirong

Publication type:

Article

Investigating the shared genetic architecture between obesity and depression: a large-scale genomewide cross-trait analysis.

Published in:

Frontiers in Endocrinology, 2025, p. 1, doi. 10.3389/fendo.2025.1578944

By:

Yuan, Lei;
Su, Yale;
Zhao, Jiangqi;
Cho, Minkyoung;
Wang, Duo;
Yuan, Long;
Li, Mixia;
Zheng, Dongdong;
Piao, Hulin;
Wang, Yong;
Zhu, Zhicheng;
Li, Dan;
Wang, Tiance;
Ha, Ki-Tae;
Park, Wonyoung;
Liu, Kexiang

Publication type:

Article

Correction: Learning the therapeutic targets of acute myeloid leukemia through multiscale human interactome network and community analysis.

Published in:

BioData Mining, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s13040-025-00451-y

By:

Sivanathan, Suruthy;
Hu, Ting

Publication type:

Article

Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.102659

By:

Ríos, Israel;
Herrero, Cristina;
Torres-Torresano, Mónica;
López-Navarro, Baltasar;
Teresa Schiaffino, María;
Díaz Crespo, Francisco;
Nieto-Valle, Alicia;
Samaniego, Rafael;
Sierra-Palomares, Yolanda;
Oliver, Eduardo;
Revuelta-Salgado, Fernando;
García-Luján, Ricardo;
Sánchez-Mateos, Paloma;
Delgado, Rafael;
Puig-Kröger, Amaya;
Corbí, Angel L.

Publication type:

Article

Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.101369

By:

Bhattacharya, Arkajyoti;
Stutvoet, Thijs S.;
Perla, Mirela;
Loipfinger, Stefan;
Jalving, Mathilde;
Reyners, Anna K. L.;
Vermeer, Paola D.;
Drapkin, Ronny;
de Bruyn, Marco;
de Vries, Elisabeth G. E.;
de Jong, Steven;
Fehrmann, Rudolf S. N.

Publication type:

Article

Investigation of Fructus sophorae extract 's therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation.

Published in:

Frontiers in Pharmacology, 2025, p. N.PAG, doi. 10.3389/fphar.2025.1571976

By:

Zheng, Jiarui;
Wang, Weiming;
Song, Wenting;
Zhang, Yehao;
Yao, Mingjiang;
Wang, Guangrui;
Huang, Zishan;
Li, Feng;
Ren, Junguo;
Lin, Li;
Fan, Xiaodi;
Liu, Jianxun

Publication type:

Article

Understanding dosage effects of traditional Chinese medicine using network analysis.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1534129

By:

Wu, Jiawei;
Guo, Dianjing

Publication type:

Article

Antimicrobial properties of Sonchus species: A review.

Published in:

Asian Pacific Journal of Tropical Biomedicine, 2025, v. 15, n. 5, p. 177, doi. 10.4103/apjtb.apjtb_42_25

By:

Zulkefle, Nurin Naziha;
Zainal, Nurhafiza;
Wahyuni, Dwi Kusuma;
Mahmood, Syed;
Ramarao, Kivaandra Dayaa Rao;
Chin, Kim Ling

Publication type:

Article

Thrombospondin‐1 binds to integrin β3 to inhibit vascular calcification through suppression of NF‐κB pathway.

Published in:

Journal of Pathology, 2025, v. 266, n. 1, p. 109, doi. 10.1002/path.6417

By:

Liu, Fang;
Liang, Qingchun;
Li, Li;
Gong, Yuan;
Li, Mingxi;
Feng, Liyun;
Chen, An;
Ye, Yuanzhi;
Lan, Zirong;
Li, Yining;
Ou, Jing‐Song;
Lu, Lihe;
Yan, Jianyun

Publication type:

Article

Contribution of alterations in peritubular capillary density and microcirculation to the progression of tubular injury and kidney fibrosis.

Published in:

Journal of Pathology, 2025, v. 266, n. 1, p. 95, doi. 10.1002/path.6414

By:

Ren, Zhengrong;
Shao, Fang;
Chen, Shuli;
Sun, Yanyan;
Ding, Zhi;
Dong, Lei;
Zhang, Junfeng;
Zang, Yuhui

Publication type:

Article

Interleukin‐11 expressed in the polyp‐enriched fibroblast subset is a potential therapeutic target in Peutz‐Jeghers syndrome.

Published in:

Journal of Pathology, 2025, v. 266, n. 1, p. 66, doi. 10.1002/path.6408

By:

Domènech‐Moreno, Eva;
Lim, Wei‐Wen;
Montrose, Melissa G;
Sévigny, Myriam;
Brandt, Anders;
Lemmetyinen, Toni T;
Viitala, Emma W;
Mäkelä, Tomi P;
Cook, Stuart A;
Ollila, Saara

Publication type:

Article

Ectopic expression of miR-34a/-328 sensitizes breast cancer stem cells to gamma rays/doxorubicin by BCL2/ABCG2 targeting.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10581-5

By:

Kouhestani, Somayeh Dehghan;
Khalili, Saeed;
Razi, Abdolah;
Aghili, Mehdi;
Moghadam, Mehdi Forouzandeh

Publication type:

Article

PacBio-based de novo transcriptomics of the coconut rhinoceros beetle Oryctes rhinoceros identifies physiologically important full-length genes and sheds insights into the molecular relationship (chitin synthase) between Scarabaeidae (Coleoptera) and Hymenoptera

Published in:

3 Biotech, 2025, v. 15, n. 6, p. 1, doi. 10.1007/s13205-025-04348-9

By:

Bhuvaragavan, Sreeramulu;
Sruthi, Kannan;
Nivetha, Ramanathan;
Keerthana, Chitti Babu;
Marieshwari, Balashanmuga Nehru;
Janarthanan, Sundaram

Publication type:

Article

Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02683-0

By:

Lin, Junzuo;
Xu, Qian;
Zhao, Zhengfei

Publication type:

Article

Computational analysis of DEHP's oncogenic role in colorectal cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02616-x

By:

Zhu, Zhou;
Qin, Jian;
He, Chungang;
Wang, Shuangyou;
Lu, Yaolin;
Wang, Shuai;
Zhong, Xiaogang

Publication type:

Article

Mast cells are key mediators in the pulmonary inflammatory response to formaldehyde exposure.

Published in:

Toxicological Sciences, 2025, v. 205, n. 1, p. 180, doi. 10.1093/toxsci/kfaf025

By:

Gibb, Matthew;
Reinert, Angela N;
Schedin, Troy;
Merrick, Daniel T;
Brown, Jared M;
Bauer, Alison K

Publication type:

Article

Matrix Remodeling Associated Genes (MXRAs): structural diversity, functional significance, and therapeutic potential in tumor microenvironments.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02728-4

By:

Zeng, Chao;
Lv, Xiao;
Wang, Feng;
Huang, Yaomin;
Ren, Yanxian;
Zhang, Hengwei

Publication type:

Article

HOX gene dysregulation in glioblastoma: a narrative review of current advances.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02684-z

By:

Hekim, Suleyman;
Bunda, Severa;
Dilibaerguli, Shaliman;
Palihati, Maierdan;
Mamatjan, Yasin

Publication type:

Article

Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02683-0

By:

Lin, Junzuo;
Xu, Qian;
Zhao, Zhengfei

Publication type:

Article

Visfatin promotes multiple myeloma cell proliferation and inhibits apoptosis by inducing IL-6 production via NF-κB pathways.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02682-1

By:

Tie, Wenting;
Ma, Tao;
Liu, Jia;
Yi, Zhigang;
Xiong, Hao;
Bai, Jun;
Li, Yanhong;
Li, Lijuan;
Zhang, Liansheng

Publication type:

Article

Sphingolipid metabolism-related genes as diagnostic markers in pneumonia-induced sepsis: the AUG model.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-01150-8

By:

Wu, Jing;
Li, Xiaomin;
Chen, Zhihao;
Lin, Yiting;
Long, Qiuyue;
Jiang, Mingzheng;
Hu, Xiaoyi;
Song, Shixu;
Ye, Hongli;
Li, Jiwei;
Wu, Fangfang;
Zheng, Jianshi;
Wang, Minghui;
Gao, Zhancheng;
Ning, Pu;
Zheng, Yali

Publication type:

Article

Dual COX-2/TNF-α Inhibitors as Promising Anti-inflammatory and Cancer Chemopreventive Agents: A Review.

Published in:

IJ Pharmaceutical Research (IJPR), 2024, v. 23, n. 1, p. 1, doi. 10.5812/ijpr-151312

By:

Tajdari, Mobina;
Peyrovinasab, Amirreza;
Bayanati, Maryam;
Rabbani, Mohammad Ismail Mahboubi;
Abdolghaffari, Amir Hossein;
Zarghi, Afshin

Publication type:

Article

Near‐Infrared Chemiluminescent Theranostics.

Published in:

Angewandte Chemie, 2025, v. 137, n. 21, p. 1, doi. 10.1002/ange.202501681

By:

Lin, Youshi;
Huang, Jingsheng;
Pu, Kanyi

Publication type:

Article

Dihydroartemisinin Attenuates Radiation‐Induced Lung Injury by Inhibiting the cGAS/STING/NF‐κB Signaling Pathway.

Published in:

Drug Development Research, 2025, v. 86, n. 3, p. 1, doi. 10.1002/ddr.70090

By:

Wang, Cailan;
Lin, Xinyi;
Guan, Shichun;
Wu, Qiaoyuan;
Liang, Shixiong

Publication type:

Article

miR‐338‐3p Targets SIRT6 to Inhibit Liver Cancer Malignancy and Paclitaxel Resistance.

Published in:

Drug Development Research, 2025, v. 86, n. 3, p. 1, doi. 10.1002/ddr.70089

By:

Huang, Yiyuan;
Huang, Sunhui;
Li, Quan;
Zhang, Hongchang;
Xiao, Wei;
Chen, Yunhui

Publication type:

Article

Upregulated Expression of SHMT2 Predicts Poor Survival of Lung Adenocarcinoma.

Published in:

Genetics Research, 2025, v. 2025, p. 1, doi. 10.1155/genr/6104753

By:

Guo, Qi;
Huang, Guang-Hong;
Chen, Pu;
Guo, Chao;
Liu, Hongda

Publication type:

Article

PHARMACOKINETICS AND PHARMACODYNAMICS PREDICTED PROFILES OF STRIGOLACTONES - BIOINFORMATICS APPROACHES.

Published in:

Romanian Journal of Biophysics, 2025, v. 35, n. 1, p. 1, doi. 10.59277/RJB.2025.1.01

By:

PĂUN, ANDRA MARIA;
TRÎMBIȚAȘ, S.;
MERNEA, MARIA;
AVRAM, SPERANțA

Publication type:

Article

Molecular Tissue Profiling in a Clinically Selected Pancreatic Cancer Cohort.

Published in:

Oncology Research & Treatment, 2025, v. 48, n. 5, p. 256, doi. 10.1159/000543997

By:

Hegenberg, Stefanie;
Germing, Tobias;
Schlageter, Elena;
Ekmekciu, Ira;
Christmann, Jens;
Tannapfel, Andrea;
Reinacher-Schick, Anke

Publication type:

Article

Assessment of MXD3 Expression as a Predictor of Survival in Lung Squamous Cell Carcinoma.

Published in:

International Journal of Genomics, 2025, v. 2025, p. 1, doi. 10.1155/ijog/7355595

By:

Cao, Mingzhi;
Zhang, Ning;
Chen, Tangbing;
Jiang, Hong;
Liu, Hongda

Publication type:

Article

Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome.

Published in:

Journal of Neurodevelopmental Disorders, 2025, v. 17, n. 1, p. 1, doi. 10.1186/s11689-025-09616-6

By:

Fenton, Timothy A.;
Petkova, Stela P.;
Adhikari, Anna;
Silverman, Jill L.

Publication type:

Article