Results
Title

Analysis of influencing factors of perioperative myasthenic crisis in 387 myasthenia gravis patients without thymoma in a single center.

Authors

Jiao, Peng; Wu, Fanjuan; Liu, Yuxing; Wu, Jiangyu; Sun, Yaoguang; Tian, Wenxin; Yu, Hanbo; Huang, Chuan; Li, Donghang; Wu, Qingjun; Ma, Chao; Tong, Hongfeng

Abstract

Objective: To study the influencing factors of myasthenic crisis in non-thymoma myasthenia gravis (MG) patients during perioperative period. Methods: We retrospectively analyzed a total of 387 non-thymoma MG patients who underwent extended thymoma resection in the Department of Thoracic Surgery of Beijing Hospital from February 2011 to December 2021, recorded ASA score, Osserman classification, preoperative course, pyridostigmine dosage, operation method, operation time, and intraoperative blood loss, then analyzed the factors associated with postoperative myasthenic crisis by univariate and multivariate logistic regression. Results: Osserman classification IIB III IV (P < 0.001), history of myasthenic crisis (P = 0.013), pyridostigmine dosage greater than 240 (P < 0.001), ASA score 2 and 3 (P = 0.001) are independent risk factors for myasthenic crisis. Conclusion: Patients with poor Osserman classification, history of myasthenic crisis before surgery, larger preoperative dosage of pyridostigmine, and higher ASA scores should be highly alert to the occurrence of postoperative myasthenic crisis.

Subjects

BEIJING (China); MYASTHENIA gravis; THYMECTOMY; FACTOR analysis; SURGICAL blood loss; THYMOMA; DRUG dosage

Publication

Journal of Cardiothoracic Surgery, 2023, Vol 18, Issue 1, p1

ISSN

1749-8090

Publication type

Academic Journal

DOI

10.1186/s13019-023-02136-1