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- Title
A systemic immune challenge to model hospital-acquired infections independently regulates immune responses after pediatric traumatic brain injury.
- Authors
Sharma, Rishabh; Zamani, Akram; Dill, Larissa K; Sun, Mujun; Chu, Erskine; Robinson, Marcus J; O'Brien, Terence J; Shultz, Sandy R; Semple, Bridgette D
- Abstract
Traumatic brain injury (TBI) is a major cause of disability in young children, yet the factors contributing to poor outcomes in this population are not well understood. TBI patients are highly susceptible to nosocomial infections, which are mostly acquired within the first week of hospitalization, and such infections may modify TBI pathobiology and recovery. In this study, we hypothesized that a peripheral immune challenge such as lipopolysaccharide (LPS)-mimicking a hospital-acquired infection-would worsen outcomes after experimental pediatric TBI, by perpetuating the inflammatory immune response.
- Publication
Journal of neuroinflammation, 2021, Vol 18, Issue 1, p72
- ISSN
1742-2094
- Publication type
Journal Article
- DOI
10.1186/s12974-021-02114-1