Works matching DE "IMMUNE checkpoint proteins"

Results: 5000

Toll-like receptor 3 activation enhances antitumor immune response in lung adenocarcinoma through NF-κB signaling pathway.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1585747

By:

Li, Ang;
Luo, Man;
Liu, Xiyao;
Wu, Hongjiao;
Liu, Xiaoguang;
Zhang, Zhi;
Zhang, Xuemei

Publication type:

Article

Personalized treatment decision-making using a machine learning-derived lactylation signature for breast cancer prognosis.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1540018

By:

Min, Simin;
Zhang, Xiaonan;
Liu, Yuling;
Wang, Weiqiang;
Guan, Jingwen;
Chen, Yuyan;
Sun, Meng;
Wang, Ziheng;
Wang, Tao

Publication type:

Article

Tumor immune microenvironment alterations associated with progression in human intraductal papillary mucinous neoplasms.

Published in:

Journal of Pathology, 2025, v. 266, n. 1, p. 40, doi. 10.1002/path.6402

By:

Jamouss, Kevin T;
Damanakis, Alexander Ioannis;
Cornwell, Abigail C;
Jongepier, Martine;
Trujillo, Maria A;
Pflüger, Michael Johannes;
Kawalerski, Ryan;
Maalouf, Alexandre;
Hirose, Katsuya;
Datta, Shalini;
Sipes, Abigail;
Pedro, Brian A;
Gudmundsson, Emma;
Assarzadegan, Naziheh;
Engle, Logan;
Scharpf, Robert B;
Kawamoto, Satomi;
Thompson, Elizabeth D;
Wood, Laura D

Publication type:

Article

CD2AP shapes a stromal reduced tumor microenvironment and contributes to immunotherapy in gastric cancer.

Published in:

BMC Cancer, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12885-025-14248-z

By:

Li, Haoliang;
Chen, Hua;
Zhao, Ting;
Zhang, Wenqi;
Deng, Jing;
Xie, Wangkai;
Fan, Jianing;
Lou, Han;
Dong, Pingping;
Han, Zheng;
Xing, Dong;
Mao, Sunzhong;
Shen, Xian;
Xue, Xiangyang;
Lu, Mingdong

Publication type:

Article

Integrative single-cell and spatial transcriptomics analysis reveals MDK-NCL pathway's role in shaping the immunosuppressive environment of lung adenocarcinoma.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1546382

By:

Fu, Yu;
Li, Song;
Zhao, Yikang;
Zhang, Xiran;
Mao, Xiaolu;
Xu, Ran

Publication type:

Article

The emerging role of lymphocyte‐activation gene 3 targeting in the treatment of solid malignancies.

Published in:

Cancer (0008543X), 2025, v. 131, n. 10, p. 1, doi. 10.1002/cncr.35892

By:

Giri, Vinay K.;
McDermott, David F.;
Zaemes, Jacob

Publication type:

Article

An immune-based predictive model for HBV clearance: validation in multicenter cohorts and mechanistic insights from in vivo studies.

Published in:

Virology Journal, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12985-025-02792-w

By:

Zhang, Rongzheng;
Qiao, Han;
Zhou, Kun;
Ju, Xiaomei;
Cao, Xinyang;
Dong, Jianming;
Wu, Meng;
Yu, Le;
Zhang, Shuyun

Publication type:

Article

Unraveling the immunomodulatory role of TIM-3 in head and neck squamous cell carcinoma: implications for targeted therapy.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02673-2

By:

Xu, Shuang;
Luo, Yang;
He, Yuzhu;
Chen, Yuxiang;
Qin, Fengfeng;
Hu, Wenjian

Publication type:

Article

Advancements in Cancer Therapy: Mycoviruses and Their Oncolytic Potential.

Published in:

Cell Biochemistry & Biophysics, 2025, v. 83, n. 2, p. 1329, doi. 10.1007/s12013-024-01608-y

By:

Kamala, Kannan;
Ganapathy, Dhanraj;
Sivaperumal, Pitchiah

Publication type:

Article

Cytoplasmic HMGB1 promotes the activation of JAK2-STAT3 signaling and PD-L1 expression in breast cancer.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01235-0

By:

Han, Ju-Young;
Rhee, Woo Joong;
Shin, Jeon-Soo

Publication type:

Article

An Extremely Rare Case of Immune Checkpoint Inhibitors–Related Hypoparathyroidism and a Critical Literature Review Open Access.

Published in:

JCEM Case Reports, 2025, v. 3, n. 6, p. 1, doi. 10.1210/jcemcr/luaf097

By:

Kazanas, Spyridon;
Anastasopoulou, Amalia;
Ziogas, Dimitrios;
Gogas, Helen;
Angelousi, Anna

Publication type:

Article

Itolizumab regulates activating and inhibitory signals on effector cells, improving their cytotoxicity against CD318+ tumor cell lines.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1585597

By:

González Muñoz, Cynthia;
Álvarez Arzola, Rydell;
Calvo Pérez, Adanays;
Frometa Campanón, Milagro de la Caridad;
Hernández Casaña, Patricia;
Fernández-Calienes Valdés, Aymé;
Lorenzo-Luaces, Patricia;
Mazorra Herrera, Zaima;
Crombet Ramos, Tania;
Labrada Mon, Mayrel

Publication type:

Article

AUNIP was a candidate marker for prognosis and immunology in pan-cancer.

Published in:

3 Biotech, 2025, v. 15, n. 6, p. 1, doi. 10.1007/s13205-025-04294-6

By:

Guo, Xiaorong;
Liu, Ting;
Li, Nan;
Jin, Li

Publication type:

Article

Novel exosome-associated LncRNA model predicts colorectal cancer prognosis and drug response.

Published in:

Hereditas, 2025, v. 162, n. 1, p. 1, doi. 10.1186/s41065-025-00445-0

By:

Zhou, Chi;
Qiu, Qian;
Liu, Xinyu;
Zhang, Tiantian;
Liang, Leilei;
Yuan, Yihang;
Chen, Yufo;
Sun, Weijie

Publication type:

Article

PD‐L1, PD‐1, and CTLA‐4 mRNA In Situ Expression by Canine Oral Melanoma Cells and Immune Cells of the Tumour Microenvironment.

Published in:

Veterinary & Comparative Oncology, 2025, v. 23, n. 2, p. 141, doi. 10.1111/vco.13039

By:

Foiani, Greta;
Melchiotti, Erica;
Capello, Katia;
Porcellato, Ilaria;
Brachelente, Chiara;
Iussich, Selina;
Giacobino, Davide;
Morello, Emanuela;
Martano, Marina;
Buracco, Paolo;
Vascellari, Marta

Publication type:

Article

A novel pH-sensitive nanoparticles encapsulating anti-PD-1 antibody and MDK-siRNA overcome immune checkpoint blockade resistance in HCC via reshaping immunosuppressive TME.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2025, v. 44, n. 1, p. 1, doi. 10.1186/s13046-025-03396-6

By:

Xu, Hai;
Li, Shuo;
Liu, Yifan;
Sung, Yoon-Young;
Zhou, Yong;
Wu, Huikun

Publication type:

Article

Tumor microenvironment and immune-related myositis: addressing muscle wasting in cancer immunotherapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1580108

By:

Ma, Shuang;
Zhao, Guangyu;
Sui, Shang;
Chen, Xiankai;
Wu, Linxin;
Wang, Taihang;
Xu, Wanying;
Lu, Zhijiao;
Wang, Andong;
Wu, Xiaolin;
Wu, Jiaxuan;
Liu, Yi;
Yan, Tao

Publication type:

Article

A comprehensive pan-cancer analysis of LRFN4: its potential as a prognostic biomarker and therapeutic target for immunotherapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1539076

By:

Xu, Yinmei;
Wu, Xin;
Zhi, Peng;
Guo, Genyu;
Fu, Yankan;
You, Lukuan;
Huai, Siyuan;
Li, Jianxiong

Publication type:

Article

Expression and Clinical Significance of CXCR5 and LAG‐3 on Peripheral Blood CD8+ T Cells in Patients With Diffuse Large B‐Cell Lymphoma.

Published in:

Kaohsiung Journal of Medical Sciences, 2025, v. 41, n. 5, p. 1, doi. 10.1002/kjm2.70005

By:

Guo, Xi‐Zhe;
Guo, Ya‐Fei;
Wu, Shi‐Xin

Publication type:

Article

Diagnostic, prognostic, and immunological roles of FUT8 in lung adenocarcinoma and lung squamous cell carcinoma.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0321756

By:

Li, Zhijun;
Zhu, Zhenpeng;
Wang, Peng;
Hou, Chenyang;
Ren, Lijuan;
Xu, Dandan;
Wang, Xiran;
Guo, Fei;
Meng, Qingxue;
Liang, Weizheng;
Xue, Jun;
Zhi, Xuejun

Publication type:

Article

Inhibiting ADORA1 enhances glioma apoptosis and increases its sensitivity to anti-PD1 therapy.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1545780

By:

Li, Hong-jiang;
Yu, Zhi-yun;
Gao, Hua-ping;
Xu, Yi-ran;
Li, Xue-yuan;
Jiang, Wei;
Chen, Di;
Yan, Dong-ming;
Yang, Chao;
Liu, Xian-zhi

Publication type:

Article

Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1589243

By:

Ma, Kexin;
Mao, Qingjie;
Fei, Bing;
Ni, Tingting;
Zhang, Zhenxin;
Ni, Haosheng

Publication type:

Article

Complete remission of a high-risk, locally advanced cervical cancer with para-aortic lymph node metastases treated with first-line tislelizumab plus bevacizumab combined with chemotherapy followed by radiotherapy with maintenance therapy: a case report.

Published in:

2025

By:

Lang, Juan;
Liu, Qianqian;
Ji, Rong;
Qiu, Miao;
Wang, Siben;
Liu, Qingmeng;
Li, Dapeng;
Chen, Ping;
Xiong, Zhongkui

Publication type:

Case Study

Dedifferentiated liposarcomas treated with immune checkpoint blockade: the MD Anderson experience.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1567736

By:

Torres, Madeline B.;
Leung, Cheuk Hong;
Zoghbi, Marianne;
Lazcano, Rossana;
Ingram, Davis;
Wani, Khalida;
Keung, Emily Z.;
Zarzour, M. Alejandra;
Scally, Christopher P.;
Hunt, Kelly K.;
Conley, Anthony;
Bishop, Andrew J.;
Guadagnolo, B. Ashleigh;
Farooqi, Ahsan;
Mitra, Devarati;
Yoder, Alison K.;
Nakazawa, Michael S.;
Araujo, Dejka;
Livingston, Andrew;
Ratan, Ravin

Publication type:

Article

Unraveling the Specific Recognition Between PD-L1 and Engineered CLP002 Functionalized Gold Nanostructures: MD Simulation Studies.

Published in:

Molecules, 2025, v. 30, n. 9, p. 2045, doi. 10.3390/molecules30092045

By:

Giannetti, Micaela;
Gobbo, Marina;
Litti, Lucio;
Caligiuri, Isabella;
Rizzolio, Flavio;
Meneghetti, Moreno;
Mazzuca, Claudia;
Palleschi, Antonio

Publication type:

Article

Editorial: Interaction of cell subtypes in tumor microenvironment, and implications for immunotherapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1600338

By:

Jiang, Hong;
Fu, Lingfeng;
Ishimoto, Takatsugu;
Zhang, Tao;
Zhang, Jun

Publication type:

Article

Sepsis-induced immunosuppression: mechanisms, biomarkers and immunotherapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1577105

By:

Gao, Xun;
Cai, Shijie;
Li, Xiao;
Wu, Guoqiu

Publication type:

Article

Immune Checkpoint Inhibitor-Related Sjögren's Syndrome: An Ocular Immune-Related Adverse Event.

Published in:

2025

By:

Fukuoka, Hideki;
Matsumoto, Akifumi;
Sotozono, Chie

Publication type:

Case Study

The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma.

Published in:

Cells (2073-4409), 2025, v. 14, n. 9, p. 632, doi. 10.3390/cells14090632

By:

Raymakers, Léon;
Passchier, Elsemieke M.;
Verdonschot, Meggy E. L.;
Evers, Mitchell;
Chan, Chilam;
Kuijpers, Karel C.;
Raicu, G. Mihaela;
Molenaar, I. Quintus;
van Santvoort, Hjalmar C.;
Strijbis, Karin;
Intven, Martijn P. W.;
Daamen, Lois A.;
Leusen, Jeanette H. W.;
Olofsen, Patricia A.

Publication type:

Article

The Attractiveness of B7-H3 as a Target for Lung Cancer Treatment.

Published in:

2025

By:

Papavassiliou, Kostas A.;
Sofianidi, Amalia A.;
Papavassiliou, Athanasios G.

Publication type:

Editorial

Advancing Cancer Treatment: A Review of Immune Checkpoint Inhibitors and Combination Strategies.

Published in:

Cancers, 2025, v. 17, n. 9, p. 1408, doi. 10.3390/cancers17091408

By:

Mc Neil, Valencia;
Lee, Seung Won

Publication type:

Article

Identifying immune‐related prognostic biomarkers in osteosarcoma: Development and validation of the tumor immune microenvironment risk model based on analysis of TCGA.

Published in:

Environmental Toxicology, 2025, v. 40, n. 6, p. 867, doi. 10.1002/tox.24208

By:

Zhang, Xiao;
Fan, Yizhe;
Shen, Zhongyuan;
Chen, Zhiyu;
You, Wulin

Publication type:

Article

Based on Soluble Immune Checkpoints Constructing a Random Survival Forest Model to Predict the Prognosis of Hepatitis B Virus-Associated Hepatocellular Carcinoma.

Published in:

OncoTargets & Therapy, 2025, v. 18, p. 559, doi. 10.2147/OTT.S512838

By:

Cai, Xue;
Yu, Lihua;
Liu, Xiaoli;
Yan, Huiwen;
Xie, Yuqing;
Pu, Qing;
Shang, Zimeng;
Wu, Yuan;
Jiang, Tingting;
Yang, Zhiyun

Publication type:

Article

An anti-androgen resistance-related gene signature acts as a prognostic marker and increases enzalutamide efficacy via PLK1 inhibition in prostate cancer.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06457-8

By:

Zhuang, Ruilin;
Xie, Ruihui;
Peng, Shirong;
Zhou, Qianghua;
Lin, Weilong;
Ou, Yuan;
Chen, Bingliang;
Su, Tong;
Li, Zean;
Huang, Hai;
Li, Kaiwen;
Duan, Yu

Publication type:

Article

CD274 (PD-L1) Polymorphisms as Predictors of Efficacy in First-Line Platinum-Based Chemotherapy for Extensive-Stage Small Cell Lung Cancer.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 9, p. 4245, doi. 10.3390/ijms26094245

By:

Barba, Andrés;
López-Vilaró, Laura;
Ferre, Malena;
Martinez-Recio, Sergio;
Majem, Margarita;
Sullivan, Ivana;
Salazar, Juliana

Publication type:

Article

Immune checkpoint inhibitor-associated Vogt-Koyanagi-Harada-like syndrome: A descriptive systematic review.

Published in:

Journal of Ophthalmic Inflammation & Infection, 2025, v. 15, n. 1, p. 1, doi. 10.1186/s12348-025-00484-8

By:

Zhang, Huixin Anna;
Yuan, Amelia T.;
Chiasson, Noémie;
Wu, Kevin Y.;
Kalevar, Ananda

Publication type:

Article

ERMAP attenuates DSS-induced colitis in mice by regulating macrophage and T cell functions.

Published in:

BMC Gastroenterology, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12876-025-03840-z

By:

Xia, Lu;
Pan, Yiwen;
Wang, Xianbin;
Hu, Rong;
Gao, Jie;
Chen, Wei;
He, Keke;
Cui, Dongbin;
Zhao, Youbo;
Liu, Lu;
Lai, Laijun;
Su, Min

Publication type:

Article

INHBA+ macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma.

Published in:

BMC Cancer, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12885-025-14261-2

By:

Zhao, Simin;
Zhang, Yu;
Meng, Xiaoqin;
Wang, Ye;
Li, Yahui;
Li, Hao;
Zhao, Xingyu;
Yang, Pishan;
Liu, Shaopeng;
Yang, Chengzhe

Publication type:

Article

Comprehensive molecular profiling of FH-deficient renal cell carcinoma identifies molecular subtypes and potential therapeutic targets.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59513-8

By:

Zhang, Xingming;
Zhao, Junjie;
Yin, Xiaoxue;
Liang, Jiayu;
Wang, Yongquan;
Zheng, Linmao;
Tan, Ping;
Lin, Yifei;
Xu, Nanwei;
Zhu, Sha;
Chen, Junru;
Zhao, Jinge;
Hu, Xu;
Pan, Xiuyi;
Nie, Ling;
Zhang, Mengni;
Chen, Yuntian;
Zhang, Yaowen;
Liu, Haoyang;
Dai, Jindong

Publication type:

Article

Comprehensive analysis indicates DDX46 as a novel biomarker for the prognosis of lung adenocarcinoma.

Published in:

Oncology Letters, 2025, v. 29, n. 6, p. N.PAG, doi. 10.3892/ol.2025.15038

By:

Bian, Tingting;
Zheng, Miaoseng;
Wang, Ting;
Zhang, Qing;
Zhang, Jianguo;
Liu, Yifei;
Shi, Wenyu

Publication type:

Article

Durvalumab‑induced type 1 diabetes mellitus in lung adenocarcinoma: A case report and literature review.

Published in:

Oncology Letters, 2025, v. 29, n. 6, p. N.PAG, doi. 10.3892/ol.2025.15023

By:

Dong, Huijing;
Li, Shengfu;
Peng, Yanmei;
Zhang, Xu;
Zheng, Jiabin;
Xue, Chongxiang;
Zheng, Yumin;
Yu, Yixuan;
Lu, Xingyu;
Hu, Zixin;
Cui, Huijuan

Publication type:

Article

Quantifying treatment response to a macrophage-targeted therapy in combination with immune checkpoint inhibitors after exposure to conventional chemotherapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1565953

By:

Bess, Shelby N.;
Smart, Gaven K.;
Muldoon, Timothy J.

Publication type:

Article

Revealing the mechanisms and therapeutic potential of immune checkpoint proteins across diverse protein families.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1499663

By:

Liu, Ran;
Jiang, Xinyan;
Dong, Ruijuan;
Zhang, Yuting;
Gai, Cong;
Wei, Peng

Publication type:

Article

N-glycosylation of PD-L1 modulates the efficacy of immune checkpoint blockades targeting PD-L1 and PD-1.

Published in:

Molecular Cancer, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12943-025-02330-w

By:

Kaufman, Bar;
Abu-Ahmad, Muhammad;
Radinsky, Olga;
Gharra, Eman;
Manko, Tal;
Bhattacharya, Baisali;
Gologan, Daniela;
Erlichman, Nofar;
Meshel, Tsipi;
Nuta, Yoav;
Cooks, Tomer;
Elkabets, Moshe;
Ben-Baruch, Adit;
Porgador, Angel

Publication type:

Article

Long non-coding rnas as key modulators of the immune microenvironment in hepatocellular carcinoma: implications for Immunotherapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1523190

By:

Zhao, Siqi;
Chen, Fei;
Hu, Lingyu;
Li, Xiaoping;
Gao, Zhaofeng;
Chen, Minjie;
Wang, Xiaoguang;
Song, Zhengwei

Publication type:

Article

Thrombospondin-1 induces CD8+ T cell exhaustion and immune suppression within the tumor microenvironment of ovarian cancer.

Published in:

Journal of Ovarian Research, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s13048-025-01668-5

By:

Liang, Haiyan;
Zhang, Suwei

Publication type:

Article

ZACN Associated with Poor Prognosis Promotes Proliferation of Kidney Renal Clear Cell Carcinoma Cells by Inhibiting JTC801-Induced Alkaliptosis.

Published in:

Applied Biochemistry & Biotechnology, 2025, v. 197, n. 5, p. 3346, doi. 10.1007/s12010-025-05197-1

By:

Li, Yifan;
Li, Can

Publication type:

Article

Identification of PIF1 as a Ferroptosis-Related Prognostic Biomarker Correlated with Immune Infiltration in Hepatocellular Carcinoma.

Published in:

Applied Biochemistry & Biotechnology, 2025, v. 197, n. 5, p. 3311, doi. 10.1007/s12010-024-05161-5

By:

Liu, Feng;
Yin, Pengyu;
Lu, Lifang;
Yao, Jingchun;
Jiao, Baoping

Publication type:

Article

LAG-3 as a therapeutic target in melanoma.

Published in:

Oncology in Clinical Practice (2450-1654), 2025, v. 21, n. 2, p. 121, doi. 10.5603/ocp.99115

By:

Terlecka, Anna M.;
Rutkowski, Piotr;
Sobczuk, Paweł

Publication type:

Article

Plasma High-Mobility Group Box-1 and Galectin-9 in Patients with Trauma and Their Prognostic Potentials.

Published in:

Tohoku Journal of Experimental Medicine, 2025, v. 265, n. 4, p. 261, doi. 10.1620/tjem.2024.J130

By:

Toshiro Niki;
Haorile Chagan-Yasutan;
Daisuke Furushima;
Toshio Hattori;
Yugo Ashino;
Satoshi Yamanouchi;
Shigeki Kushimoto

Publication type:

Article