Left ventricular ejection fraction estimation using mutual information on technetium-99m multiple-gated SPECT scans.

Shih-Neng Yang; Shung-Shung Sun; Zhang, Geoffrey; Kuei-Ting Chou; Shih-Wen Lo; Yu-Rou Chiou; Fang-Jing Li; Tzung-Chi Huang; Yang, Shih-Neng; Sun, Shung-Shung; Chou, Kuei-Ting; Lo, Shih-Wen; Chiou, Yu-Rou; Li, Fang-Jing; Huang, Tzung-Chi

Background: A new non-linear approach was applied to calculate the left ventricular ejection fraction (LVEF) using multigated acquisition (MUGA) images.Methods: In this study, 50 patients originally for the estimation of the percentage of LVEF to monitor the effects of various cardiotoxic drugs in chemotherapy were retrospectively selected. All patients had both MUGA and echocardiography examinations (ECHO LVEF) at the same time. Mutual information (MI) theory was utilized to calculate the LVEF using MUGA imaging (MUGA MI).Results: MUGA MI estimation was significantly different from MUGA LVEF and ECHO LVEF, respectively (p Conclusions: MUGA image with the aid of MI is promising to be more interchangeable LVEF to ECHO LVEF measurement as compared with the conventional approach on MUGA image.

LEFT heart ventricle; HEART physiology; DIGITAL image processing; TECHNETIUM; RETROSPECTIVE studies; CARDIAC-gated SPECT

BioMedical Engineering OnLine, 2015, p1

1475-925X

Academic Journal

10.1186/s12938-015-0117-2