We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibition of HIV-1 infection with curcumin conjugated PEG-citrate dendrimer; a new nano formulation.
- Authors
Ebrahimi, Saeideh; Sadeghizadeh, Majid; Aghasadeghi, Mohammad Reza; Ardestani, Mehdi Shafiee; Amini, Shaghayegh Adib; Vahabpour, Roohollah
- Abstract
Nano-drug delivery systems have become a promising approach to overcoming problems such as low solubility and cellular uptake of drugs. Along with various delivery devices, dendrimers are widely used through their unique features. PEG-citrate dendrimers are biocompatible and nontoxic, with the ability to improve drug solubility. Curcumin, a naturally occurring polyphenol, has multiple beneficial properties, such as antiviral activities. However, its optimum potential has been significantly hampered due to its poor water solubility, which leads to reduced bioavailability. So, the present study attempted to address this issue and investigate its antiviral effects against HIV-1.
- Publication
BMC complementary medicine and therapies, 2024, Vol 24, Issue 1, p350
- ISSN
2662-7671
- Publication type
Journal Article
- DOI
10.1186/s12906-024-04634-8