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- Title
The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study.
- Authors
Ren, Lina; Dong, Yeqing; Zhou, Xiaojing; Zhang, Chuhao; Gao, Jiajia; Li, Lulu; Zhang, Xiao; Zeng, Min; Luo, Guoshuai; Zhang, Xiangyang
- Abstract
Background: Major depressive disorder (MDD) is a recurrent and persistent mental illness. However, there is a lack of research that distinguishes the severity of comorbid anxiety disorders in MDD, and insufficient evidence exists regarding the prevalence of MDD patients with comorbid moderate-to-severe anxiety in the Chinese population. Methods: The study included 1718 MDD patients (894 with moderate-to-severe anxiety symptoms and 824 without moderate-to-severe anxiety symptoms). Clinical symptoms and development were assessed using the Hamilton Depression Rating Scale-17 (HAMD-17), Hamilton Anxiety Rating Scale-14 (HAMA-14), Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression (CGI). The blood pressure and thyroid hormone levels were measured. Results: We found that the incidence of MDD patients with moderate-to-severe anxiety symptoms was 52.04%. The prevalence of recent suicide attempts in MDD comorbid moderate-to-severe anxiety patients was 31.8%, which was 4.24 times higher than that in patients without moderate-to-severe anxiety. Additionally, suicide attempters had elevated levels of thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb), thyroid peroxidases antibody (TPOAb), systolic blood pressure (SBP), and diastolic blood pressure (DBP) compared to non-suicide attempters. We further identified CGI score, TSH, TPOAb, and DBP as influential factors for recent suicide attempts in MDD individuals who had moderate-to-severe anxiety symptoms. These indexes could distinguish between suicide attempts and non-suicide attempts in MDD patients with moderate-to-severe anxiety symptoms. Conclusions: Our findings mainly indicated a high prevalence of recent suicide attempts in MDD patients with moderate-to-severe anxiety. Several clinical correlates, thyroid hormones, and blood pressure might contribute to recent suicide attempts in MDD patients with moderate-to-severe anxiety symptoms.
- Subjects
MENTAL depression; DIASTOLIC blood pressure; SYSTOLIC blood pressure; ATTEMPTED suicide; THYROTROPIN; SUICIDE victims; ANXIETY disorders
- Publication
BMC Psychiatry, 2025, Vol 25, Issue 1, p1
- ISSN
1471-244X
- Publication type
Academic Journal
- DOI
10.1186/s12888-025-06472-5