Long-term effects of the SLC2A9 G844A and SLC22A12 C246T variants on serum uric acid concentrations in children.

Lee, Hye Ah; Park, Bo Hyun; Park, Eun Ae; Cho, Su Jin; Kim, Hae Soon; Park, Hyesook

Background: We evaluated the effects of two single-nucleotide polymorphisms on UA concentrations in the first decade of life using repeated-measures data.Methods: We included all subjects who were followed-up at least once and for whom we had both UA and genotypic data (i.e., 375, 204, 307, and 363 patients aged 3, 5, 7, and 9 years, respectively). All participated in the Ewha Birth and Growth Cohort study. We used a mixed model analysis to estimate the longitudinal association of serum UA concentration due to the rs3825017 (SLC22A12 c. 246C > T) and rs16890979 (SLC2A9 c. 844G > A) genotypes.Results: Overall, the tracking coefficient of UA concentrations in children 3 to 9 years of age was 0.31, and was higher in boys than in girls (0.34 vs. 0.29, respectively). Regarding individual variance, serum UA concentrations decreased as age increased (β = - 0.07, p Conclusion: This study showed that rs3825017 in the SLC22A12 gene was associated with UA concentration in childhood.

SINGLE nucleotide polymorphisms; URIC acid; GENES; CHILDREN'S health; COHORT analysis; PHYSIOLOGY

BMC Pediatrics, 2018, Vol 18, Issue 1, pN.PAG

1471-2431

Academic Journal

10.1186/s12887-018-1272-y