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- Title
Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis.
- Authors
Ya-li Zhou; Chun-li Chen; Yi-xiao Wang; Yao Tong; Xiao-ling Fang; Lin Li; Zhao-yang Wang; Zhou, Ya-Li; Chen, Chun-Li; Wang, Yi-Xiao; Tong, Yao; Fang, Xiao-Ling; Li, Lin; Wang, Zhao-Yang
- Abstract
<bold>Background: </bold>Anti-angiogenesis treatments are the most commonly used treatments for the vision loss caused by exudative age-related macular degeneration (AMD), in which the anti-vascular endothelial growth factor (VEGF) drugs with ranibizumab and bevacizumab are current standard treatments. However, the outcome of anti-VEGF therapeutics is not uniform in all patients.<bold>Methods: </bold>We performed a literature-based meta-analysis including, five published studies relevant to HTRA1 and response to anti-VEGF treatment (bevacizumab or ranibizumab). Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed- and random-effects models. Sensitivity analysis and meta-regression were also performed. Q-statistic test and Egger's test was used to evaluate heterogeneity and publication bias respectively.<bold>Results: </bold>Overall, no association between the rs11200638 polymorphism in HTRA1 gene and the anti-VEGF treatment response was found in the genotype GG versus AA (OR = 1.06; 95% CI: 0.77 to 1.48; P = 0.98), genotype GA versus AA (OR = 1.11; 95% CI: 0.83 to 1.47; P = 0.93), genotype GG + GA versus AA (OR = 1.22; 95% CI: 0.94 to 1.57; P = 0.09), and allele G versus A (OR = 0.92; 95% CI: 0.78 to 1.08; P = 0.14). In the subgroup analysis by ethnicity Caucasian population, and a significant association was still not observed in all genetic models. Sensitivity analysis indicated the robustness of our findings, and no publication bias was observed in our meta-analysis.<bold>Conclusions: </bold>This study shows that there was no association between the polymorphism rs11200638 in HTRA1 gene and response to anti-VEGF treatment of exudative AMD. However, more studies are needed to further prove the conclusion of present study, especially well-designed and high quality randomised controlled trials or intervention studies.
- Subjects
RETINAL degeneration treatment; AGE factors in retinal degeneration; SERINE proteinases; VASCULAR endothelial growth factors; GENETIC polymorphisms
- Publication
BMC Ophthalmology, 2017, Vol 17, p1
- ISSN
1471-2415
- Publication type
Academic Journal
- DOI
10.1186/s12886-017-0487-2