We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy.
- Authors
Lu-Lu Zhang; Guan-Qun Zhou; Zhen-Yu Qi; Xiao-Jun He; Jia-Xiang Li; Ling-Long Tang; Yan-Ping Mao; Ai-Hua Lin; Jun Ma; Ying Sun; Zhang, Lu-Lu; Zhou, Guan-Qun; Qi, Zhen-Yu; He, Xiao-Jun; Li, Jia-Xiang; Tang, Ling-Long; Mao, Yan-Ping; Lin, Ai-Hua; Ma, Jun; Sun, Ying
- Abstract
<bold>Background: </bold>To evaluate the incidence of neck muscle spasm in nasopharyngeal carcinoma (NPC) patients that received intensity-modulated radiotherapy (IMRT), and to analyse the patient- and treatment-related risk factors associated with neck muscle spasm.<bold>Methods: </bold>A sample of 152 IMRT-treated, biopsy-proven, nondisseminated NPC patients were retrospectively analysed. All had documented IMRT treatment plans and had returned for follow-up review at 4 years post-radiotherapy. Spasm of the sternocleidomastoid (SCM) muscle was graded from 0 to 3 (absent to severe) and this grade served as the clinical endpoint. Risk factors were identified using logistic regression analysis.<bold>Results: </bold>Within 4 years of radiotherapy, neck muscle spasm developed in 23.68% of the patients; Grades 0, 1, 2 and 3 were respectively assigned to 83.55, 7.57, 6.58 and 2.30% of assessed SCMs. Multivariate analysis indicated that gender, N stage, V60 (percentage of SCM volume that received >60 Gy) were independent prognostic variables, and that the optimal threshold for using V60 to predict neck muscle spasm was 61.92% (sensitivity = 0.900, specificity = 0.953).<bold>Conclusions: </bold>Gender, N stage and V60 were independent predictive factors for post-radiotherapy neck muscle spasm, and a V60 of ≤61.92% in the SCM was relatively safe.
- Subjects
NASOPHARYNX cancer; NECK muscles; INTENSITY modulated radiotherapy; CANCER radiotherapy; RETROSPECTIVE studies
- Publication
BMC Cancer, 2017, Vol 17, p1
- ISSN
1471-2407
- Publication type
Academic Journal
- DOI
10.1186/s12885-017-3780-9