Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital.

Sirijatuphat, Rujipas; Suputtamongkol, Yupin; Angkasekwinai, Nasikarn; Horthongkham, Navin; Chayakulkeeree, Methee; Rattanaumpawan, Pinyo; Koomanachai, Pornpan; Assanasen, Susan; Rongrungruang, Yong; Chierakul, Nitipatana; Ratanarat, Ranistha; Jitmuang, Anupop; Wangchinda, Walaiporn; Kantakamalakul, Wannee

<bold>Background: </bold>The epidemiology and outcomes of COVID-19 patients in Thailand are scarce.<bold>Methods: </bold>This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020.<bold>Results: </bold>The prevalence of COVID-19 was 7.5% (107 COVID-19 patients) among 1409 patients who underwent RT-PCR for SARS-CoV-2 detection at our hospital during the outbreak period. Patients with COVID-19 presented with symptoms in 94.4%. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive.<bold>Conclusions: </bold>The prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome.

THAILAND; COVID-19; TREATMENT effectiveness; COVID-19 treatment; EPIDEMIOLOGY; SARS-CoV-2

BMC Infectious Diseases, 2021, Vol 21, Issue 1, p1

1471-2334

Academic Journal

10.1186/s12879-021-06081-z