Title: miR-320a affects spinal cord edema through negatively regulating aquaporin-1 of blood-spinal cord barrier during bimodal stage after ischemia reperfusion injury in rats.
Authors: Li, Xiao-Qian; Fang, Bo; Tan, Wen-Fei; Wang, Zhi-Lin; Sun, Xi-Jia; Zhang, Zai-Li; Ma, Hong
Abstract: Spinal cord edema is a serious complication and pathophysiological change after ischemia reperfusion (IR) injury. It has been demonstrated closely associated with bimodal disruption of blood-spinal cord barrier (BSCB) in our previous work. Aquaporin (AQP)1 plays important but contradictory roles in water homeostasis. Recently, microRNAs (miRs) effectively regulate numerous target mRNAs during ischemia. However, whether miRs are able to protect against dimodal disruption of BSCB by regulating perivascular AQP1 remains to be elucidated.
Publication: BMC neuroscience, 2016, Vol 17, p10
ISSN: 1471-2202
Publication type: Journal Article
DOI: 10.1186/s12868-016-0243-1

miR-320a affects spinal cord edema through negatively regulating aquaporin-1 of blood-spinal cord barrier during bimodal stage after ischemia reperfusion injury in rats.

Li, Xiao-Qian; Fang, Bo; Tan, Wen-Fei; Wang, Zhi-Lin; Sun, Xi-Jia; Zhang, Zai-Li; Ma, Hong