Results
Title

Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway.

Authors

Ki-Jun Yoon; Hye-Ryeon Lee; Yong Sang Jo; Kyongman An; Sang-Yong Jung; Min-Woo Jeong; Seok-Kyu Kwon; Nam-Shik Kim; Hyun-Woo Jeong; Seo-Hee Ahn; Kyong-Tai Kim; Kyungmin Lee; Eunjoon Kim; Joung-Hun Kim; June-Seek Choi; Bong-Kiun Kaang; Young-Yun Kong

Abstract

Background: Notch signaling is well recognized as a key regulator of the neuronal fate during embryonic development, but its function in the adult brain is still largely unknown. Mind bomb-1 (Mib1) is an essential positive regulator in the Notch pathway, acting non-autonomously in the signal-sending cells. Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function. Results: Here we show that the inactivation of Mib1 in mature neurons in forebrain results in impaired hippocampal dependent spatial memory and contextual fear memory. Consistently, hippocampal slices from Mib1-deficient mice show impaired late-phase, but not early-phase, long-term potentiation and long-term depression without change in basal synaptic transmission at SC-CA1 synapses. Conclusions: These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.

Subjects

NOTCH genes; NEURAL circuitry; HIPPOCAMPUS (Brain); EMBRYOLOGY; MEMORY; NEURONS

Publication

Molecular Brain, 2012, Vol 5, Issue 1, p40

ISSN

1756-6606

Publication type

Academic Journal

DOI

10.1186/1756-6606-5-40