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Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP.
- Published in:
- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 54, doi. 10.1186/1750-1326-7-54
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- Article
Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 1, doi. 10.1186/1750-1326-7-61
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- Article
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 1, doi. 10.1186/1750-1326-7-59
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- Article
The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 58, doi. 10.1186/1750-1326-7-58
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- Article
Utility of an improved model of amyloid-beta (Aβ<sub>1-42</sub>) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 57, doi. 10.1186/1750-1326-7-57
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- Article
Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 55, doi. 10.1186/1750-1326-7-55
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Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 50, doi. 10.1186/1750-1326-7-50
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- Article
Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 60, doi. 10.1186/1750-1326-7-60
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- Article
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 49, doi. 10.1186/1750-1326-7-49
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- Article
BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's disease.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 52, doi. 10.1186/1750-1326-7-52
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- Article
Regulated protein aggregation: stress granules and neurodegeneration.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 56, doi. 10.1186/1750-1326-7-56
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- Article
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 53, doi. 10.1186/1750-1326-7-53
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- Article
Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 51, doi. 10.1186/1750-1326-7-51
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- Article
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 48, doi. 10.1186/1750-1326-7-48
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- Article
Neuromuscular effects of G93A-SOD1 expression in zebrafish.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 44, doi. 10.1186/1750-1326-7-44
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- Article
ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 43, doi. 10.1186/1750-1326-7-43
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- Article
Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 45, doi. 10.1186/1750-1326-7-45
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- Article
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 36, doi. 10.1186/1750-1326-7-36
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- Article
Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 34, doi. 10.1186/1750-1326-7-34
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Exosomal cell-to-cell transmission of alpha synuclein oligomers.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 42, doi. 10.1186/1750-1326-7-42
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- Article
IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 47, doi. 10.1186/1750-1326-7-47
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- Article
Identification of BACE2 as an avid β-amyloid-degrading protease.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 46, doi. 10.1186/1750-1326-7-46
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- Article
Progranulin regulates neuronal outgrowth independent of Sortilin.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 33, doi. 10.1186/1750-1326-7-33
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Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 21, doi. 10.1186/1750-1326-7-21
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FE65 as a link between VLDLR and APP to regulate their trafficking and processing.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 9, doi. 10.1186/1750-1326-7-9
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- Article
Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrP<sup>res</sup> level disparity.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 18, doi. 10.1186/1750-1326-7-18
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- Article
Mass spectrometry quantification of clusterin in the human brain.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 41, doi. 10.1186/1750-1326-7-41
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Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 39, doi. 10.1186/1750-1326-7-39
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Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 38, doi. 10.1186/1750-1326-7-38
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- Article
L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-X<sub>L</sub>.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 40, doi. 10.1186/1750-1326-7-40
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- Article
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 37, doi. 10.1186/1750-1326-7-37
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- Article
Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 24, doi. 10.1186/1750-1326-7-24
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Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with á-synuclein at the single molecule level.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 35, doi. 10.1186/1750-1326-7-35
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Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington's disease.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 20, doi. 10.1186/1750-1326-7-20
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Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 12, doi. 10.1186/1750-1326-7-12
- Publication type:
- Article
Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 17, doi. 10.1186/1750-1326-7-17
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The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 15, doi. 10.1186/1750-1326-7-15
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- Article
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 8, doi. 10.1186/1750-1326-7-8
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- Article
Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 4, doi. 10.1186/1750-1326-7-4
- Publication type:
- Article
Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer's disease: a stochastic modelling approach.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 32, doi. 10.1186/1750-1326-7-32
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- Article
LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 31, doi. 10.1186/1750-1326-7-31
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- Article
Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 30, doi. 10.1186/1750-1326-7-30
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- Article
Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 28, doi. 10.1186/1750-1326-7-28
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- Article
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 25, doi. 10.1186/1750-1326-7-25
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- Article
Does a loss of TDP-43 function cause neurodegeneration?
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 27, doi. 10.1186/1750-1326-7-27
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- Article
A molecular signature in blood identifies early Parkinson's disease.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 26, doi. 10.1186/1750-1326-7-26
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- Article
Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 16, doi. 10.1186/1750-1326-7-16
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- Article
Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 29, doi. 10.1186/1750-1326-7-29
- Publication type:
- Article
Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn<sup>2+</sup> in cognitively intact aged individuals with Alzheimer's disease neuropathology.
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- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 23, doi. 10.1186/1750-1326-7-23
- Publication type:
- Article
Regulation of mitochondrial permeability transition pore by PINK1.
- Published in:
- Molecular Neurodegeneration, 2012, v. 7, n. 1, p. 22, doi. 10.1186/1750-1326-7-22
- Publication type:
- Article