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Title: Skp2 and Skp2B team up against Rb and p53.
Authors: Germain, Doris
Abstract: The Skp2 locus encodes two proteins, Skp2 and Skp2B. The role of Skp2 in the ubiquitin-dependent degradation of key regulators of the retinoblastoma protein pathway has been well established. More recent work from the McCormick's group suggested that Skp2 has an ubiquitin-independent function in the regulation of the p53 pathway. Adding to this observation, we reported that Skp2B also regulates the activity of p53 by degrading a distinct substrate, prohibitin. Since prohibitin has been implicated in the regulation of the Rb pathway, collectively, these observations suggest that Skp2 and Skp2B team up against p53 and Rb.
Subjects: LOCUS (Genetics); PROTEINS; RETINOBLASTOMA; P53 protein; UBIQUITIN
Publication: Cell Division, 2011, Vol 6, Issue 1, p1
ISSN: 1747-1028
Publication type: Academic Journal
DOI: 10.1186/1747-1028-6-1

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Skp2 and Skp2B team up against Rb and p53.