We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism.
- Authors
Huerta, Consuelo; Johansson, Saga; Wallander, Mari-Ann; García Rodríguez, Luis A.
- Abstract
Background: Venous thromboembolism (VTE) and thromboembolic arterial diseases are usually considered to be distinct entities, but there is evidence to suggest that these disorders may be linked. The aim of this study was to determine whether a diagnosis of VTE increases the long-term risk of myocardial infarction (MI). Methods: The incidence rate (IR) and relative risk (RR) of MI in a cohort of patients with a diagnosis of VTE (n = 4890) compared with that of a control cohort without prior VTE (n = 43 382) were evaluated in the UK General Practice Research Database (GPRD). Death during follow-up was also determined. Patients were followed for up to 8 years (mean of 3 years). Results: The IR of MI per 1000 person-years was 4.1 (95% CI: 3.1-5.3) for the VTE cohort and 3.5 (95% CI: 3.2-3.8) for the control cohort. The IR of MI was highest in the first year after the VTE episode, but overall differences between the two cohorts were not significant (RR of MI associated with VTE: 1.2; 95% CI: 0.9-1.6). The risk of death was higher in the VTE cohort than the control cohort, even after adjustment for cancer, heart failure and ischaemic heart disease (RR: 2.4; 95% CI: 2.2-2.6), particularly during the first year after VTE (RR: 3.8; 95% CI: 3.4-4.3). Conclusion: A VTE episode does not significantly increase the risk of MI, but does increase the risk of death, particularly in the first year following VTE diagnosis.
- Subjects
UNITED Kingdom; THROMBOEMBOLISM; VENOUS thrombosis; MYOCARDIAL infarction; MORTALITY; HEART failure; CORONARY disease; PATIENTS
- Publication
Thrombosis Journal, 2008, Vol 6, p1
- ISSN
1477-9560
- Publication type
Academic Journal
- DOI
10.1186/1477-9560-6-10