Risk factors for suicide behaviors in the observational schizophrenia outpatient health outcomes (SOHO) study.

Brugnoli, Roberto; Novick, Diego; Maria Haro, Josep; Rossi, Andrea; Bortolomasi, Marco; Frediani, Sonia; Borgherini, Giuseppe

Background: To identify risk factors for suicide using data from a large, 3-year, multinational follow-up study of schizophrenia (SOHO study). Methods: Baseline characteristics of 8,871 adult patients with schizophrenia were included in a logistic regression post-hoc analysis comparing patients who attempted and/or committed suicide during the study with those who did not. Results: 384 (4.3%) patients attempted or committed suicide. Completed suicides were 27 (0.3%). The significant risk factors for suicide behaviors were previous suicidality, depressive symptoms, prolactin-related adverse events, male gender and history of hospitalization for schizophrenia. Conclusions: In view of the observational design of the study and the post-hoc nature of the analysis, the identified risk factors should be confirmed by ad-hoc specifically designed studies.

DISEASE risk factors; SUICIDE; SUICIDAL behavior; SCHIZOPHRENIA; OUTPATIENT medical care; MENTAL depression; DEPRESSED persons

BMC Psychiatry, 2012, Vol 12, Issue 1, p83

1471-244X

Academic Journal

10.1186/1471-244X-12-83