Works matching DE "RAF genes"

Results: 88

Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAF<sup>V600E</sup> inhibition and can be targeted to reduce resistance.

Published in:

Oncogene, 2015, v. 34, n. 7, p. 857, doi. 10.1038/onc.2014.21

By:

Serasinghe, M N;
Missert, D J;
Asciolla, J J;
Podgrabinska, S;
Wieder, S Y;
Izadmehr, S;
Belbin, G;
Skobe, M;
Chipuk, J E

Publication type:

Article

Mutations of the BRAF gene in human cancer, by Davies et al. ( Nature 2002; 417: 949-54).

Published in:

Clinical & Experimental Dermatology, 2013, v. 38, n. 2, p. 222, doi. 10.1111/ced.12015

By:

Millington, G. W. M.

Publication type:

Article

A novel Noonan syndrome RAF1 mutation: lethal course in a preterm infant.

Published in:

Pediatric Reports, 2015, v. 7, n. 2, p. 35, doi. 10.4081/pr.2015.5955

By:

Ratola, Ana;
Silva, Helena Moreira;
Guedes, Ana;
Mota, Céu;
Braga, Ana Cristina;
Oliveira, Dulce;
Alegria, Artur;
Carvalho, Carmen;
Álvares, Sílvia;
Proença, Elisa

Publication type:

Article

An association between the reduced levels of SLC1A2 and GAD1 in the dorsolateral prefrontal cortex in major depressive disorder: possible involvement of an attenuated RAF/MEK/ERK signaling pathway.

Published in:

Journal of Neural Transmission, 2014, v. 121, n. 7, p. 783, doi. 10.1007/s00702-014-1189-z

By:

Oh, Dong;
Oh, Daeyoung;
Son, Hyeon;
Webster, Maree;
Weickert, Cyndi;
Kim, Seok

Publication type:

Article

Tumor adaptation and resistance to RAF inhibitors.

Published in:

Nature Medicine, 2013, v. 19, n. 11, p. 1401, doi. 10.1038/nm.3392

By:

Lito, Piro;
Rosen, Neal;
Solit, David B

Publication type:

Article

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.

Published in:

Nature Genetics, 2015, v. 47, n. 3, p. 250, doi. 10.1038/ng.3218

By:

Lin, Luping;
Chan, Elton;
Olivas, Victor;
Cade, Lindsay;
Pazarentzos, Evangelos;
Asthana, Saurabh;
Neel, Dana;
Yan, Jenny Jiacheng;
Lu, Xinyuan;
Pham, Luu;
Wang, Mingxue M;
Collisson, Eric A;
Algazi, Alain;
Bivona, Trever G;
Muñoz-Couselo, Eva;
Cortes, Javier;
Frederick, Dennie T;
Flaherty, Keith T;
Cooper, Zachary A;
Wargo, Jennifer A

Publication type:

Article

Case series: indoor-photosensitivity caused by fluorescent lamps in patients treated with vemurafenib for metastatic melanoma.

Published in:

BMC Cancer, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2407-14-967

By:

Boudewijns, Steve;
Gerritsen, Winald R.;
Koornstra, Rutger H.

Publication type:

Article

Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy.

Published in:

BMC Cancer, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2407-14-258

By:

Robinson, Giles W.;
Orr, Brent A.;
Gajjar, Amar

Publication type:

Article

Severe pan-uveitis in a patient treated with vemurafenib for metastatic melanoma.

Published in:

BMC Cancer, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2407-13-561

By:

EJ Wolf, Sanne;
Meenken, Christina;
Moll, Annette C.;
Haanen, John B.;
van der Heijden, Michiel S.

Publication type:

Article

Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line.

Published in:

2013

By:

Huan Gu;
Xianquan Zhan;
Guiying Zhang;
Lu Yan;
Cho, William C. S.;
Maoyu Li;
Ting Liu;
Zhuchu Chen;
Gu, Huan;
Zhan, Xianquan;
Zhang, Guiying;
Yan, Lu;
Cho, William Cs;
Li, Maoyu;
Liu, Ting;
Chen, Zhuchu

Publication type:

journal article

CD45RAFoxp3 regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma.

Published in:

Cancer Immunology, Immunotherapy, 2017, v. 66, n. 10, p. 1275, doi. 10.1007/s00262-017-2021-z

By:

Ihara, Fumie;
Sakurai, Daiju;
Horinaka, Atsushi;
Makita, Yuji;
Fujikawa, Akira;
Sakurai, Toshioki;
Yamasaki, Kazuki;
Kunii, Naoki;
Motohashi, Shinichiro;
Nakayama, Toshinori;
Okamoto, Yoshitaka

Publication type:

Article

Mécanismes de résistances aux inhibiteurs de RAF : revue de la littérature.

Published in:

Oncologie (Tech Science Press), 2012, v. 14, n. 1, p. 2, doi. 10.1007/s10269-011-2100-2

By:

Rousseau pour l'Aerio, B.

Publication type:

Article

CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo.

Published in:

Carcinogenesis, 2013, v. 34, n. 5, p. 1134, doi. 10.1093/carcin/bgt015

By:

Kim, Dong Joon;
Lee, Mee-Hyun;
Reddy, Kanamata;
Li, Yani;
Lim, Do Young;
Xie, Hua;
Lee, Sung-Young;
Yeom, Young Il;
Bode, Ann M.;
Dong, Zigang

Publication type:

Article

The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance.

Published in:

Carcinogenesis, 2013, v. 34, n. 2, p. 237, doi. 10.1093/carcin/bgs330

By:

Wroblewski, David;
Mijatov, Branka;
Mohana-Kumaran, Nethia;
Lai, Fritz;
Gallagher, Stuart J.;
Haass, Nikolas K.;
Zhang, Xu Dong;
Hersey, Peter

Publication type:

Article

Molecular Alterations in Partially-Encapsulated or Well-Circumscribed Follicular Variant of Papillary Thyroid Carcinoma.

Published in:

Thyroid, 2013, v. 23, n. 10, p. 1256, doi. 10.1089/thy.2013.0018

By:

Howitt, Brooke E.;
Jia, Yonghui;
Sholl, Lynette M.;
Barletta, Justine A.

Publication type:

Article

Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0126603

By:

Yue, Rongcai;
Li, Xia;
Chen, Bingyang;
Zhao, Jing;
He, Weiwei;
Yuan, Hu;
Yuan, Xing;
Gao, Na;
Wu, Guozhen;
Jin, Huizi;
Shan, Lei;
Zhang, Weidong

Publication type:

Article

Trametinib with or without Vemurafenib in BRAF Mutated Non-Small Cell Lung Cancer.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0118210

By:

Joshi, Monika;
Rice, Shawn J.;
Liu, Xin;
Miller, Bruce;
Belani, Chandra P.

Publication type:

Article

BRAF<sup>V600E</sup> Mutation and Its Association with Clinicopathological Features of Colorectal Cancer: A Systematic Review and Meta-Analysis.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090607

By:

Chen, Dong;
Huang, Jun-Fu;
Liu, Kai;
Zhang, Li-Qun;
Yang, Zhao;
Chuai, Zheng-Ran;
Wang, Yun-Xia;
Shi, Da-Chuan;
Huang, Qing;
Fu, Wei-Ling

Publication type:

Article

An RNAi-Based Dimorphic Genetic Screen Identified the Double Bromodomain Protein BET-1 as a Sumo-Dependent Attenuator of RAS-Mediated Signalling.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0083659

By:

Gee, Fiona;
Fisher, Kate;
Klemstein, Ulrike;
Poulin, Gino B.

Publication type:

Article

Regulation of mTORC1 Signaling by pH.

Published in:

PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0021549

By:

Balgi, Aruna D.;
Diering, Graham H.;
Donohue, Elizabeth;
Lam, Karen K. Y.;
Fonseca, Bruno D.;
Zimmerman, Carla;
Numata, Masayuki;
Roberge, Michel

Publication type:

Article

a1A-Adrenergic Receptor Induces Activation of Extracellular Signal-Regulated Kinase 1/2 through Endocytic Pathway.

Published in:

PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0021520

By:

Liu, Fei;
He, Kangmin;
Yang, Xinxing;
Xu, Ning;
Liang, Zhangyi;
Xu, Ming;
Zhao, Xinsheng;
Han, Qide;
Zhang, Youyi

Publication type:

Article

B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy.

Published in:

Cardiovascular Research, 2014, v. 102, n. 1, p. 88, doi. 10.1093/cvr/cvu024

By:

Kramann, Nadine;
Hasenfuß, Gerd;
Seidler, Tim

Publication type:

Article

Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells.

Published in:

2017

By:

Safi, Sher Zaman;
Qvist, Rajes;
Ong, Gracie;
Karimian, Hamed;
Imran, Muhammad;
Shah, Ikram

Publication type:

journal article

Apoptosis in glioma-bearing rats after neural stem cell transplantation.

Published in:

Neural Regeneration Research, 2013, v. 8, n. 19, p. 1793, doi. 10.3969/j.issn.1673-5374.2013.19.007

By:

Hua Li;
Zhenjun Chen;
Shaopeng Zhou

Publication type:

Article

Correction.

Published in:: 2012
Publication type:: Correction Notice

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.

Published in:

Molecular Systems Biology, 2017, v. 13, n. 1, p. n/a, doi. 10.15252/msb.20166796

By:

Fallahi‐Sichani, Mohammad;
Becker, Verena;
Izar, Benjamin;
Baker, Gregory J;
Lin, Jia‐Ren;
Boswell, Sarah A;
Shah, Parin;
Rotem, Asaf;
Garraway, Levi A;
Sorger, Peter K

Publication type:

Article

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 5, p. 2155, doi. 10.1172/JCI65780

By:

Abel, Ethan V.;
Basile, Kevin J.;
Kugel III, Curtis H.;
Witkiewicz, Agnieszka K.;
Le, Kaitlyn;
Amaravadi, Ravi K.;
Karakousis, Giorgos C.;
Xiaowei Xu;
Wei Xu;
Schuchter, Lynn M.;
Lee, Jason B.;
Ertel, Adam;
Fortina, Paolo;
Aplin, Andrew E.

Publication type:

Article

Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond.

Published in:

Nature Reviews Cancer, 2014, v. 14, n. 7, p. 455, doi. 10.1038/nrc3760

By:

Holderfield, Matthew;
Deuker, Marian M.;
McCormick, Frank;
McMahon, Martin

Publication type:

Article

Pentoxifylline inhibits hepatic stellate cells proliferation via the Raf/ ERK pathway.

Published in:

APMIS, 2012, v. 120, n. 7, p. 572, doi. 10.1111/j.1600-0463.2011.02868.x

By:

Zhang, Di;
Jiang, Huiqing;
Wang, Yan;
Ma, Junji

Publication type:

Article

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Published in:

PLoS ONE, 2017, v. 12, n. 10, p. 1, doi. 10.1371/journal.pone.0185862

By:

Merchant, Mark;
Moffat, John;
Schaefer, Gabriele;
Chan, Jocelyn;
Wang, Xi;
Orr, Christine;
Cheng, Jason;
Hunsaker, Thomas;
Shao, Lily;
Wang, Stephanie J.;
Wagle, Marie-Claire;
Lin, Eva;
Haverty, Peter M.;
Shahidi-Latham, Sheerin;
Ngu, Hai;
Solon, Margaret;
Eastham-Anderson, Jeffrey;
Koeppen, Hartmut;
Huang, Shih-Min A.;
Schwarz, Jacob

Publication type:

Article

RKIP and 14-3-3ε Exert an Opposite Effect on Human Gastric Cancer Cells SGC7901 by Regulating the ERK/MAPK Pathway Differently.

Published in:

Digestive Diseases & Sciences, 2013, v. 58, n. 2, p. 389, doi. 10.1007/s10620-012-2341-y

By:

Yan, Lu;
Gu, Huan;
Li, Jia;
Xu, Meihua;
Liu, Ting;
Shen, Yueming;
Chen, Bolin;
Zhang, Guiying

Publication type:

Article

TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development.

Published in:

Immunogenetics, 2013, v. 65, n. 10, p. 703, doi. 10.1007/s00251-013-0717-6

By:

Perricone, Carlo;
Ciccacci, Cinzia;
Ceccarelli, Fulvia;
Fusco, Davide;
Spinelli, Francesca;
Cipriano, Enrica;
Novelli, Giuseppe;
Valesini, Guido;
Conti, Fabrizio;
Borgiani, Paola

Publication type:

Article

The importance of Raf dimerization in cell signaling.

Published in:

Small GTPases, 2013, v. 4, n. 3, p. 180, doi. 10.4161/sgtp.26117

By:

Freeman, Alyson K;
Ritt, Daniel A;
Morrison, Deborah K

Publication type:

Article

Raf kinases in signal transduction and interaction with translation machinery.

Published in:

Biomolecular Concepts, 2013, v. 4, n. 4, p. 391, doi. 10.1515/bmc-2013-0003

By:

Migliaccio, Nunzia;
Sanges, Carmen;
Ruggiero, Immacolata;
Martucci, Nicola M.;
Rippa, Emilia;
Arcari, Paolo;
Lamberti, Annalisa

Publication type:

Article

Identification of a novel MTAP-RAF1 fusion in a soft tissue sarcoma.

Published in:

Diagnostic Pathology, 2018, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13000-018-0759-z

By:

Hicks, J. Kevin;
Henderson-Jackson, Evita;
Duggan, Julia;
Joyce, David M.;
Brohl, Andrew S.

Publication type:

Article

Molecular mechanisms of asymmetric RAF dimer activation.

Published in:

Biochemical Society Transactions, 2014, v. 42, n. 4, p. 784, doi. 10.1042/BST20140025

By:

Jambrina, Pablo G.;
Bohuszewicz, Olga;
Buchete, Nicolae-Viorel;
Kolch, Walter;
Rosta, Edina

Publication type:

Article

The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration.

Published in:

Biology of the Cell (Wiley-Blackwell), 2013, v. 105, n. 2, p. 91, doi. 10.1111/boc.201200030

By:

Klingauf, Mirko;
Beck, Matthias;
Berge, Ulrich;
Turgay, Yagmur;
Heinzer, Stephan;
Horvath, Peter;
Kroschewski, Ruth

Publication type:

Article

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells.

Published in:

2018

By:

Molnár, Eszter;
Rittler, Dominika;
Baranyi, Marcell;
Grusch, Michael;
Berger, Walter;
Döme, Balázs;
Tóvári, József;
Aigner, Clemens;
Tímár, József;
Garay, Tamás;
Hegedűs, Balázs

Publication type:

journal article

A-Raf: A new star of the family of raf kinases.

Published in:

Critical Reviews in Biochemistry & Molecular Biology, 2015, v. 50, n. 6, p. 520, doi. 10.3109/10409238.2015.1102858

By:

An, Su;
Yang, Yang;
Ward, Richard;
Liu, Ying;
Guo, Xiao-Xi;
Xu, Tian-Rui

Publication type:

Article

The Ras/ MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications.

Published in:

European Journal of Clinical Investigation, 2015, v. 45, n. 6, p. 609, doi. 10.1111/eci.12441

By:

Delire, Bénédicte;
Stärkel, Peter

Publication type:

Article

Anti-inflammatory effects of dabrafenib in vitro and in vivo.

Published in:

Canadian Journal of Physiology & Pharmacology, 2017, v. 95, n. 6, p. 697, doi. 10.1139/cjpp-2016-0519

By:

Lee, In-Chul;
Kim, Jongdoo;
Bae, Jong-Sup

Publication type:

Article

NF-κB Regulation of c-FLIP Promotes TNFα-Mediated RAF Inhibitor Resistance in Melanoma.

Published in:

Journal of Investigative Dermatology, 2015, v. 135, n. 7, p. 1839, doi. 10.1038/jid.2015.91

By:

Shao, Yongping;
Le, Kaitlyn;
Cheng, Hanyin;
Aplin, Andrew E

Publication type:

Article

RAF Inhibition Overcomes Resistance to TRAIL-Induced Apoptosis in Melanoma Cells.

Published in:

Journal of Investigative Dermatology, 2014, v. 134, n. 2, p. 430, doi. 10.1038/jid.2013.347

By:

Berger, Anja;
Quast, Sandra-Annika;
Plötz, Michael;
Kuhn, Nicholas-Frederik;
Trefzer, Uwe;
Eberle, Jürgen

Publication type:

Article

Resistance to RAF Inhibitors Revisited.

Published in:

Journal of Investigative Dermatology, 2014, v. 134, n. 2, p. 319, doi. 10.1038/jid.2013.358

By:

Hartsough, Edward;
Shao, Yongping;
Aplin, Andrew E

Publication type:

Article

A STATement on Vemurafenib-Resistant Melanoma.

Published in:

Journal of Investigative Dermatology, 2013, v. 133, n. 8, p. 1928, doi. 10.1038/jid.2013.136

By:

Hartsough, Edward J;
Aplin, Andrew E

Publication type:

Article

Abiotic stress-induced accumulation of raffinose in Arabidopsis leaves is mediated by a single raffinose synthase (RS5, At5g40390).

Published in:

BMC Plant Biology, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2229-13-218

By:

Egert, Aurélie;
Keller, Felix;
Peters, Shaun

Publication type:

Article

The important roles of RET, VEGFR2 and the RAF/MEK/ERK pathway in cancer treatment with sorafenib.

Published in:

Acta Pharmacologica Sinica, 2012, v. 33, n. 10, p. 1311, doi. 10.1038/aps.2012.76

By:

Mao, Wei-feng;
Shao, Min-hua;
Gao, Pin-ting;
Ma, Ji;
Li, Hui-juan;
Li, Gai-ling;
Han, Bao-hui;
Yuan, Chong-gang

Publication type:

Article

Therapeutics: iterations of BRAF.

Published in:

2012

By:

Alderton, Gemma K.

Publication type:

journal article

TRPC1/3/6 inhibition attenuates the TGF‐β1‐induced epithelial–mesenchymal transition in gastric cancer via the Ras/Raf1/ERK signaling pathway.

Published in:

Cell Biology International, 2018, v. 42, n. 8, p. 975, doi. 10.1002/cbin.10963

By:

Ge, Pengbo;
Wei, Linting;
Zhang, Mingkai;
Hu, Baoguang;
Wang, Kai;
Li, Yanbin;
Liu, Shuaichen;
Wang, Jianping;
Li, Yuming

Publication type:

Article

Combination therapies to inhibit the RAF/MEK/ERK pathway in melanoma: we are not done yet.

Published in:

Frontiers in Oncology, 2015, p. 1, doi. 10.3389/fonc.2015.00161

By:

McArthur, Grant A.;
Sullivan, Ryan J.;
Lito, Piro;
Smalley, Keiran

Publication type:

Article