Results
Title

Radiation-induced temporal lobe injury after intensity modulated radiotherapy in nasopharyngeal carcinoma patients: a dose-volume-outcome analysis.

Authors

Ying Sun; Guan-Qun Zhou; Zhen-Yu Qi; Li Zhang; Shao-Min Huang; Li-Zhi Liu; Li Li; Ai-Hua Lin; Jun Ma; Sun, Ying; Zhou, Guan-Qun; Qi, Zhen-Yu; Zhang, Li; Huang, Shao-Min; Liu, Li-Zhi; Li, Li; Lin, Ai-Hua; Ma, Jun

Abstract

Background: To identify the radiation volume effect and significant dosimetric parameters for temporal lobe injury (TLI) and determine the radiation dose tolerance of the temporal lobe (TL) in nasopharyngeal carcinoma (NPC) patients treated with intensity modulated radiation therapy (IMRT).Methods: Twenty NPC patients with magnetic resonance imaging (MRI)-diagnosed unilateral TLI were reviewed. Dose-volume data was retrospectively analyzed.Results: Paired samples t-tests showed all dosimetric parameters significantly correlated with TLI, except the TL volume (TLV) and V₇₅ (the TLV that received ≥75 Gy, P = 0.73 and 0.22, respectively). Receiver operating characteristic (ROC) curves showed V₁₀ and V₂₀ (P = 0.552 and 0.11, respectively) were the only non-significant predictors from V₁₀ to V₇₀ for TLI. D(0.5cc) (dose to 0.5 ml of the TLV) was an independent predictor for TLI (P Conclusions: A D0.5cc of 69 Gy may be the dose tolerance of the TL. The risk of TLI was highly dependent on high dose 'hot spots' in the TL; physicians should be cautious of such 'hot spots' in the TL during IMRT treatment plan optimization, review and approval.

Subjects

RADIOTHERAPY; RADIATION doses; DIAGNOSTIC imaging; MAGNETIC fields; MAGNETIC resonance imaging

Publication

BMC Cancer, 2013, Vol 13, Issue 1, p1

ISSN

1471-2407

Publication type

Academic Journal

DOI

10.1186/1471-2407-13-397