Works matching DE "DRUG repositioning"

Results: 1895

Epigenetic Therapies in Melanoma—Targeting DNA Methylation and Histone Modification.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1188, doi. 10.3390/biomedicines13051188

By:

Tigu, Adrian Bogdan;
Ivancuta, Andrei;
Uhl, Andrada;
Sabo, Alexandru Cristian;
Nistor, Madalina;
Mureșan, Ximena-Maria;
Cenariu, Diana;
Timis, Tanase;
Diculescu, Doru;
Gulei, Diana

Publication type:

Article

A Unified Framework for Alzheimer's Disease Knowledge Graphs: Architectures, Principles, and Clinical Translation.

Published in:

Brain Sciences (2076-3425), 2025, v. 15, n. 5, p. 523, doi. 10.3390/brainsci15050523

By:

Dobreva, Jovana;
Simjanoska Misheva, Monika;
Mishev, Kostadin;
Trajanov, Dimitar;
Mishkovski, Igor

Publication type:

Article

Biology-Informed Matrix Factorization: An AI-Driven Framework for Enhanced Drug Repositioning.

Published in:

Biology (2079-7737), 2025, v. 14, n. 5, p. 549, doi. 10.3390/biology14050549

By:

Wang, Yangyang;
Wang, Yaping;
Hu, Ya;
Wang, Jihan

Publication type:

Article

Synthesis Methods and Therapeutic Journey of Carprofen and Its Derivatives: A Review.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 5, p. 1, doi. 10.1111/cbdd.70122

By:

Limban, Carmen;
Nuță, Diana Camelia;
Caproiu, Miron Teodor;
Dumitrescu, Denisa Elena;
Papacocea, Șerban Iancu;
Bordei, Alexandra Teodora;
Dumitrașcu, Florea

Publication type:

Article

Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in Trypanosoma cruzi : Virtual Screening and In Vitro Studies.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 669, doi. 10.3390/ph18050669

By:

Ortiz-Pérez, Eyra;
Moreno-Rodríguez, Adriana;
Delgado-Maldonado, Timoteo;
Ortega-Balleza, Jessica L.;
González-González, Alonzo;
Paz-González, Alma D.;
Vázquez, Karina;
Avalos-Navarro, Guadalupe;
Giovannuzzi, Simone;
Supuran, Claudiu T.;
Rivera, Gildardo

Publication type:

Article

Systems Biology-Driven Discovery of Host-Targeted Therapeutics for Oropouche Virus: Integrating Network Pharmacology, Molecular Docking, and Drug Repurposing.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 613, doi. 10.3390/ph18050613

By:

Dev Sharma, Pranab;
Alhudhaibi, Abdulrahman Mohammed;
Al Noman, Abdullah;
Abdallah, Emad M.;
Taha, Tarek H.;
Sharma, Himanshu

Publication type:

Article

Evolution of Antiviral Drug Resistance in SARS-CoV-2.

Published in:

Viruses (1999-4915), 2025, v. 17, n. 5, p. 722, doi. 10.3390/v17050722

By:

Dinata, Roy;
Baindara, Piyush;
Mandal, Santi M.

Publication type:

Article

P-Glycoprotein as a Therapeutic Target in Hematological Malignancies: A Challenge to Overcome.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4701, doi. 10.3390/ijms26104701

By:

Álvarez-Carrasco, Pablo;
Morales-Villamil, Fernanda;
Maldonado-Bernal, Carmen

Publication type:

Article

The Use of Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressants in the Treatment of Lung Cancer.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4546, doi. 10.3390/ijms26104546

By:

Özkaya Gül, Serap;
Aydemir, Esra

Publication type:

Article

Molecular Dynamics-Guided Repositioning of FDA-Approved Drugs for PD-L1 Inhibition with In Vitro Anticancer Potential.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4497, doi. 10.3390/ijms26104497

By:

Jiang, Dejun;
Yoou, Myoung-Schook;
Cho, Sungjoon;
Choi, Youngjin

Publication type:

Article

Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization study.

Published in:

BMC Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12916-025-04127-6

By:

Huang, Xin;
Zhao, Jie V.

Publication type:

Article

基于SPO 语义三元组的自闭症谱系障碍药物知识发现.

Published in:

Chinese Nursing Research, 2024, v. 38, n. 5, p. 796, doi. 10.12102/j.issn.1009-6493.2024.05.007

By:

吕艳华;
赵宏霞;
李琦;
梁傲雪;
于琦

Publication type:

Article

Drug Repositioning of Pioglitazone in Management and Improving the Cognitive Function among the Patients With Mild to Moderate Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Published in:

Neurology India, 2023, v. 71, n. 6, p. 1132, doi. 10.4103/0028-3886.391397

By:

Basutkar, Roopa;
Sudarsan, Pooja;
Robin, Sandra;
Bhaskar, Vahini;
Viswanathan, Balasubramaniam;
Sivasankaran, Ponnusankar

Publication type:

Article

Risk factors associated with the onset of lomustine‐induced neutropenia in tumour‐bearing dogs.

Published in:

Veterinary & Comparative Oncology, 2022, v. 20, n. 3, p. 577, doi. 10.1111/vco.12809

By:

Treggiari, Elisabetta;
Cossu, Giovanna;
Valenti, Paola;
Taylor, Angela

Publication type:

Article

Inclusion Complexes of Gold(I)‐Dithiocarbamates with β‐Cyclodextrin: A Journey from Drug Repurposing towards Drug Discovery.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 47, p. 12156, doi. 10.1002/chem.202101366

By:

Morgen, Michael;
Fabrowski, Piotr;
Amtmann, Eberhard;
Gunkel, Nikolas;
Miller, Aubry K.

Publication type:

Article

Repurposing serotonergic drugs for gastric cancer: induction of apoptosis in vitro.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10474-7

By:

Abedini, Fatemeh;
Amjadi, Omolbanin;
Ahangari, Ghasem

Publication type:

Article

A complex bearing TSPO PIGA ligand coordinated to the [Au(PEt<sub>3</sub>)]<sup>+</sup> pharmacophore is highly cytotoxic against ovarian cancer cells.

Published in:

BioMetals, 2023, v. 36, n. 5, p. 961, doi. 10.1007/s10534-023-00496-8

By:

Chiaverini, Lorenzo;
Baglini, Emma;
Mannelli, Michele;
Poggetti, Valeria;
Da Settimo, Federico;
Taliani, Sabrina;
Gamberi, Tania;
Barresi, Elisabetta;
La Mendola, Diego;
Marzo, Tiziano

Publication type:

Article

Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future.

Published in:

2025

By:

Li, Junfang;
Wang, Xiaodong;
Zhang, Honghua;
Hu, Xiaoling;
Peng, Xue;
Jiang, Weifan;
Zhuo, Linsheng;
Peng, Yan;
Zeng, Guo;
Wang, Zhen

Publication type:

Literature Review

Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies.

Published in:

Medicinal Research Reviews, 2024, v. 44, n. 5, p. 2078, doi. 10.1002/med.22033

By:

Das, Viswanath;
Miller, John H.;
Alladi, Charanraj Goud;
Annadurai, Narendran;
De Sanctis, Juan Bautista;
Hrubá, Lenka;
Hajdúch, Marián

Publication type:

Article

Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics.

Published in:

Medicinal Research Reviews, 2022, v. 42, n. 4, p. 1704, doi. 10.1002/med.21889

By:

Gong, Shilin;
Hu, Xiaolan;
Chen, Shengshuang;
Sun, Baoqing;
Wu, Jian‐Lin;
Li, Na

Publication type:

Article

Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition.

Published in:

Medicinal Research Reviews, 2022, v. 42, n. 2, p. 744, doi. 10.1002/med.21862

By:

Macip, Guillem;
Garcia‐Segura, Pol;
Mestres‐Truyol, Júlia;
Saldivar‐Espinoza, Bryan;
Ojeda‐Montes, María José;
Gimeno, Aleix;
Cereto‐Massagué, Adrià;
Garcia‐Vallvé, Santiago;
Pujadas, Gerard

Publication type:

Article

Natural products as geroprotectors: An autophagy perspective.

Published in:

Medicinal Research Reviews, 2021, v. 41, n. 6, p. 3118, doi. 10.1002/med.21815

By:

Raj, Stephen D.;
Fann, David Y.;
Wong, Esther;
Kennedy, Brian K.

Publication type:

Article

Recent pharmacological advances in the repurposing of artemisinin drugs.

Published in:

Medicinal Research Reviews, 2021, v. 41, n. 6, p. 3156, doi. 10.1002/med.21837

By:

Meng, Yuqing;
Ma, Nan;
Lyu, Haining;
Wong, Yin Kwan;
Zhang, Xing;
Zhu, Yongping;
Gao, Peng;
Sun, Peng;
Song, Yali;
Lin, Lizhu;
Wang, Jigang

Publication type:

Article

How to make the best of NLRP3 inhibitors in patients with COVID-19?

Published in:

2023

By:

Kow, Chia Siang;
Ramachandram, Dinesh Sangarran;
Hasan, Syed Shahzad

Publication type:

Letter to the Editor

Drug repositioning in the COVID-19 pandemic: fundamentals, synthetic routes, and overview of clinical studies.

Published in:

European Journal of Clinical Pharmacology, 2023, v. 79, n. 6, p. 723, doi. 10.1007/s00228-023-03486-4

By:

Vaz, Elisa Souza;
Vassiliades, Sandra Valeria;
Giarolla, Jeanine;
Polli, Michelle Carneiro;
Parise-Filho, Roberto

Publication type:

Article

Emerging therapeutic strategies in glioblastsoma: drug repurposing, mechanisms of resistance, precision medicine, and technological innovations.

Published in:

Clinical & Experimental Medicine, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10238-025-01631-0

By:

Anwer, Mohamed S.;
Abdel-Rasol, Mohammed A.;
El-Sayed, Wael M.

Publication type:

Article

Hunting the main protease of SARS-CoV-2 by plitidepsin: Molecular docking and temperature-dependent molecular dynamics simulations.

Published in:

Amino Acids, 2022, v. 54, n. 2, p. 205, doi. 10.1007/s00726-021-03098-1

By:

Vishvakarma, Vijay Kumar;
Singh, Madhur Babu;
Jain, Pallavi;
Kumari, Kamlesh;
Singh, Prashant

Publication type:

Article

New and Repurposed Drugs for the Treatment of Active Tuberculosis: An Update for Clinicians.

Published in:

Respiration, 2023, v. 102, n. 2, p. 83, doi. 10.1159/000528274

By:

Aguilar Diaz, Jessica M;
Abulfathi, Ahmed A;
te Brake, Lindsey HM;
van Ingen, Jakko;
Kuipers, Saskia;
Magis-Escurra, Cecile;
Raaijmakers, Jelmer;
Svensson, Elin M;
Boeree, Martin J

Publication type:

Article

Revamped role for approved drug: integrative computational and biophysical analysis of saquinavir's peptidyl arginine deiminase 4 inhibition for rheumatoid arthritis.

Published in:

Biochemical Journal, 2024, v. 481, n. 20, p. 1379, doi. 10.1042/BCJ20240366

By:

Thirugnanasambandham, Indhumathi;
Jupudi, Srikanth;
Roychowdhury, Parikshit;
Reddy Karri, Veera Venkata Satyanarayana;
Madhunapantula, Subba Rao V.;
Singh, Sachin Kumar;
Subramaniyan, Vetriselvan;
Kuppusamy, Gowthamarajan

Publication type:

Article

Polypharmacological repurposing approach identifies approved drugs as potential inhibitors of Mycobacterium tuberculosis.

Published in:

Biochemical Journal, 2023, v. 480, n. 14, p. 1079, doi. 10.1042/BCJ20230143

By:

Singh, Jasdeep;
Quadir, Neha;
Vashishtha, Shubham;
Chakraborty, Ankan;
Alam, Anwar;
Kundu, Bishwajit;
Ahmad, Uzair;
Sundar, Durai;
Ehtesham, Nasreen Z.;
Hasnain, Seyed E.

Publication type:

Article

REPURPOSING EMPAGLIFLOZIN TO TREAT NEUTROPENIA IN A TURKISH GIRL WITH GLYCOGEN STORAGE DISEASE TYPE 1B.

Published in:

Turkish Medical Student Journal, 2024, v. 11, n. 2, p. 50, doi. 10.4274/tmsj.galenos.2024.2024-2-1

By:

Özkan, Hasan Selçuk;
Aydın, Ece Derin;
Mammadova, Sakina;
Çoker, Mahmut

Publication type:

Article

Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-01763-5

By:

Niwata, Chieko;
Nakagawa, Takayuki;
Naruse, Takako;
Sakuma, Miyuki;
Yamakado, Nao;
Akagi, Misaki;
Ono, Shigehiro;
Tobiume, Kei;
Gao, Jing;
Jimi, Eijiro;
Ohta, Kouji;
Aikawa, Tomonao

Publication type:

Article

Multi-output prediction of dose–response curves enables drug repositioning and biomarker discovery.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00691-x

By:

Gutierrez, Juan-José Giraldo;
Lau, Evelyn;
Dharmapalan, Subhashini;
Parker, Melody;
Chen, Yurui;
Álvarez, Mauricio A.;
Wang, Dennis

Publication type:

Article

Scientific figures interpreted by ChatGPT: strengths in plot recognition and limits in color perception.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00576-z

By:

Wang, Jinge;
Ye, Qing;
Liu, Li;
Guo, Nancy Lan;
Hu, Gangqing

Publication type:

Article

Integrative transcriptome-wide analysis of atopic dermatitis for drug repositioning.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03564-w

By:

Song, Jaeseung;
Kim, Daeun;
Lee, Sora;
Jung, Junghyun;
Joo, Jong Wha J.;
Jang, Wonhee

Publication type:

Article

Integrative transcriptome-wide analysis of atopic dermatitis for drug repositioning.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03564-w

By:

Song, Jaeseung;
Kim, Daeun;
Lee, Sora;
Jung, Junghyun;
Joo, Jong Wha J.;
Jang, Wonhee

Publication type:

Article

Drug repositioning of polaprezinc for bone fracture healing.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03424-7

By:

Ko, Eun Ae;
Park, Yoo Jung;
Yoon, Dong Suk;
Lee, Kyoung-Mi;
Kim, Jihyun;
Jung, Sujin;
Lee, Jin Woo;
Park, Kwang Hwan

Publication type:

Article

Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02854-z

By:

Liu, Yuan;
Tong, Ziwen;
Shi, Jingru;
Jia, Yuqian;
Deng, Tian;
Wang, Zhiqiang

Publication type:

Article

TRANSLATIONAL RESEARCH ON GASTRIC CANCER: BIOMARKERS AND DRUG REPURPOSING.

Published in:

Genetics & Applications, 2023, p. 2

By:

Chen Duan

Publication type:

Article

Rare Disease Drug Repurposing.

Published in:

JAMA Network Open, 2025, v. 8, n. 5, p. e258330, doi. 10.1001/jamanetworkopen.2025.8330

By:

Nijim, Sally;
Korsunska, Ania;
Zinski, Joseph;
Bolden, Sarah E.;
Zuccato, Mary;
Repasky, Mileva;
Fajgenbaum, David C.

Publication type:

Article

Strategies to Advance Drug Repurposing for Rare Diseases.

Published in:

2025

By:

Hong, Dongzhe;
Kesselheim, Aaron S.

Publication type:

Opinion

Repurposing Alzheimer's disease medications—systemic cholinesterase inhibitors—for the treatment of dry eye syndrome, glaucoma, and age-related macular degeneration.

Published in:

2025

By:

Rajagopal, Shilpa;
Ahuja, Pranati;
Quach, Valerie;
Luong, Cody;
Raji, Mukaila A.

Publication type:

Editorial

Storage and Query of Drug Knowledge Graphs Using Distributed Graph Databases: A Case Study.

Published in:

Bioengineering (Basel), 2025, v. 12, n. 2, p. 115, doi. 10.3390/bioengineering12020115

By:

Han, Xingjian;
Tian, Yu

Publication type:

Article

Leveraging Genomic and Bioinformatic Analysis to Enhance Drug Repositioning for Dermatomyositis.

Published in:

Bioengineering (Basel), 2023, v. 10, n. 8, p. 890, doi. 10.3390/bioengineering10080890

By:

Irham, Lalu Muhammad;
Adikusuma, Wirawan;
La'ah, Anita Silas;
Chong, Rockie;
Septama, Abdi Wira;
Angelina, Marissa

Publication type:

Article

Impacts of host factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression.

Published in:

Journal of Immunoassay & Immunochemistry, 2024, v. 45, n. 6, p. 493, doi. 10.1080/15321819.2024.2429538

By:

Salum, Ghada M.;
Abd el Meguid, Mai;
Fotouh, Basma E.;
Dawood, Reham M.

Publication type:

Article

Reinforcing our defense or weakening the enemy? A comparative overview of defensive and offensive strategies developed to confront COVID-19.

Published in:

Drug Metabolism Reviews, 2021, v. 53, n. 4, p. 508, doi. 10.1080/03602532.2021.1928686

By:

Khodajou-Masouleh, Hamidreza;
Shahangian, S. Shirin;
Rasti, Behnam

Publication type:

Article

Recent progress on drugs discovery study for treatment of COVID-19: repurposing existing drugs and current natural bioactive molecules.

Published in:

Applied Biological Chemistry, 2023, v. 66, n. 1, p. 1, doi. 10.1186/s13765-023-00842-x

By:

Oktavianawati, Ika;
Santoso, Mardi;
Bakar, Mohd Fadzelly Abu;
Kim, Yong-Ung;
Fatmawati, Sri

Publication type:

Article

Drug Repurposing and Computational Drug Discovery: Strategies and Advances: Editor Mithun Rudrapal, Florida, CRC Press, 2023, 294pp., £ 39.19 (Ebook), ISBN: 978-1-00334-770-5.

Published in:

2024

By:

Khatami, Fajri;
Hairima, Hestia;
Fitria, Roudhotul

Publication type:

Book Review

Doses, serum concentrations and diagnoses of Norwegian quetiapine users 2001–2019 in a therapeutic drug monitoring material.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2024, v. 135, n. 4, p. 523, doi. 10.1111/bcpt.14074

By:

Breivik, Håvard;
Westin, Andreas Austgulen;
Frost, Joachim

Publication type:

Article

Drug repurposing for obsessive-compulsive disorder using deep learning-based binding affinity prediction models.

Published in:

AIMS Neuroscience, 2024, v. 11, n. 2, p. 1, doi. 10.3934/Neuroscience.2024013

By:

Papikinos, Thomas;
Krokidis, Marios;
Vrahatis, Aris;
Vlamos, Panagiotis;
Exarchos, Themis P.

Publication type:

Article