Independent Risk Factors Associated With Venous Thromboembolism After Knee Arthroscopy: A Retrospective Study of 222 Patients.

Wu, Jinlong; Huangfu, Xiaoqiao; Yan, Xiaoyu; Dong, Shikui; Xie, Guoming; Zhao, Song; Xu, Caiqi; Xu, Junjie; Zhao, Jinzhong

Background: A serious complication after knee arthroscopy is venous thromboembolism (VTE), which includes both deep vein thrombosis (DVT) and pulmonary embolism (PE). However, asymptomatic VTE is frequently undetected. Purpose: To (1) report the incidence of VTE after knee arthroscopy using ultrasound examination and computed tomography pulmonary angiography (CTPA) and (2) discover the independent risk factors of VTE after knee arthroscopy and determine the corresponding cutoff values of these indicators. Study Design: Case-control study; Level of evidence, 3. Methods: Included were 222 patients (115 male) who underwent arthroscopic knee procedures between October 2022 and January 2023. Baseline characteristics, blood test results, and VTE assessments were collected. During the 2-week follow-up, routine lower extremity vascular ultrasound was applied for DVT measurement, with CTPA evaluation for suspected PE. Patients were allocated into VTE and no-VTE groups, and descriptive statistics were used to analyze baseline data. Logistic regression analysis was used to determine the correlation between binary variables and the presence of postoperative VTE. Multivariate logistic regression analysis was further performed to determine the independent risk factors of VTE. Results: Of the 222 patients, 37 (16.7%) had DVT and 1 (0.5%) had both DVT and PE. Compared to the no-VTE group, the VTE group was significantly older, with more female patients; higher body mass index (BMI) and postoperative D-dimer level; and higher rates of hypertension, hyperlipidemia, varicose veins of the lower extremity, and abnormal postoperative fibrin degradation product level (P ≤.043 for all). Notably, operative time >20 minutes was not significantly associated with postoperative VTE (P =.513). The independent risk factors for VTE included age >32 years (odds ratio [OR], 20.71 [95% CI, 4.40-97.47]; P <.001), BMI >23 kg/m2 (OR, 3.52 [95% CI, 1.11-11.14]; P =.032), hyperlipidemia (OR, 6.81 [95% CI, 1.86-24.88]; P =.004), and postoperative D-dimer level >0.63 mg/L (OR, 34.01 [95% CI, 7.36-157.07]; P <.001). Conclusion: The incidence of VTE after knee arthroscopy was 16.7% at the 2-week follow-up. Age >32 years, BMI >23 kg/m2, hyperlipidemia, and postoperative D-dimer >0.63 mg/L were independent risk factors of postoperative VTE within 2 weeks after knee arthroscopy. For patients with knee arthroscopy, the cutoff value of postoperative D-dimer for VTE was found to be 0.63 mg/L for timely intervention.

LEG physiology; THROMBOEMBOLISM risk factors; RISK assessment; PULMONARY embolism; STATISTICAL correlation; BLOOD testing; BODY mass index; HYPERLIPIDEMIA; DATA analysis; RECEIVER operating characteristic curves; RESEARCH funding; VEINS; ARTHROSCOPY; BLOOD vessels; COMPUTED tomography; VENOUS thrombosis; LOGISTIC regression analysis; MULTIPLE regression analysis; HYPERTENSION; QUESTIONNAIRES; FISHER exact test; RETROSPECTIVE studies; DESCRIPTIVE statistics; MULTIVARIATE analysis; FIBRIN fibrinogen degradation products; VARICOSE veins; AGE distribution; CHI-squared test; KNEE joint; SURGICAL complications; ODDS ratio; THROMBOEMBOLISM; CASE-control method; RESEARCH; STATISTICS; COMPARATIVE studies; CONFIDENCE intervals; DATA analysis software; PATIENT aftercare; TIME; SENSITIVITY & specificity (Statistics)

Orthopaedic Journal of Sports Medicine, 2024, Vol 12, Issue 8, p1

2325-9671

Academic Journal

10.1177/23259671241257820