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- Title
Brain atrophy and clinical characteristics predicting SDMT performance in multiple sclerosis: A 10-year follow-up study.
- Authors
Jacobsen, Cecilie; Zivadinov, Robert; Myhr, Kjell-Morten; Dalaker, Turi O; Dalen, Ingvild; Benedict, Ralph HB; Bergsland, Niels; Farbu, Elisabeth
- Abstract
Objectives: To identify Magnetic Resonance Imaging (MRI), clinical and demographic biomarkers predictive of worsening information processing speed (IPS) as measured by Symbol Digit Modalities Test (SDMT). Methods: Demographic, clinical data and 1.5 T MRI scans were collected in 76 patients at time of inclusion, and after 5 and 10 years. Global and tissue-specific volumes were calculated at each time point. For the primary outcome of analysis, SDMT was used. Results: Worsening SDMT at 5-year follow-up was predicted by baseline age, Expanded Disability Status Scale (EDSS), SDMT, whole brain volume (WBV) and T2 lesion volume (LV), explaining 30.2% of the variance of SDMT. At 10-year follow-up, age, EDSS, grey matter volume (GMV) and T1 LV explained 39.4% of the variance of SDMT change. Conclusion: This longitudinal study shows that baseline MRI-markers, demographic and clinical data can help predict worsening IPS. Identification of patients at risk of IPS decline is of importance as follow-up, treatment and rehabilitation can be optimized.
- Subjects
CEREBRAL atrophy; MULTIPLE sclerosis; MAGNETIC resonance imaging; FORECASTING
- Publication
Multiple Sclerosis Journal - Experimental, Translational & Clinical, 2021, p1
- ISSN
2055-2173
- Publication type
Academic Journal
- DOI
10.1177/2055217321992394