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- Title
Relapse recovery in multiple sclerosis: Effect of treatment and contribution to long-term disability.
- Authors
Sotiropoulos, Marinos G; Lokhande, Hrishikesh; Healy, Brian C; Polgar-Turcsanyi, Mariann; Glanz, Bonnie I; Bakshi, Rohit; Weiner, Howard L; Chitnis, Tanuja
- Abstract
Background: Although recovery from relapses in MS appears to contribute to disability, it has largely been ignored as a treatment endpoint and disability predictor. Objective: To identify demographic and clinical predictors of relapse recovery in the first 3 years and examine its contribution to 10-year disability and MRI outcomes. Methods: Relapse recovery was retrospectively assessed in 360 patients with MS using the return of the Expanded Disability Status Scale (EDSS), Functional System Scale and neurologic signs to baseline at least 6 months after onset. Univariate and multivariable models were used to associate recovery with demographic and clinical factors and predict 10-year outcomes. Results: Recovery from relapses in the first 3 years was better in patients who were younger, on disease-modifying treatment, with a longer disease duration and without bowel or bladder symptoms. For every incomplete recovery, 10-year EDSS increased by 0.6 and 10-year timed 25-foot walk increased by 0.5 s. These outcomes were also higher with older age and higher baseline BMI. Ten-year MRI brain atrophy was associated only with older age, and MRI lesion volume was only associated with smoking. Conclusions: Early initiation of disease-modifying treatment in MS was associated with improved relapse recovery, which in turn prevented long-term disability.
- Subjects
DISABILITIES; MULTIPLE sclerosis; TREATMENT effectiveness; CEREBRAL atrophy; SYMPTOMS; PEOPLE with disabilities
- Publication
Multiple Sclerosis Journal - Experimental, Translational & Clinical, 2021, p1
- ISSN
2055-2173
- Publication type
Academic Journal
- DOI
10.1177/20552173211015503