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- Title
Cyclosporine-induced thrombotic microangiopathy in pregnant women: A case report and literature review.
- Authors
Zhang, Su; Zhou, Hai-hui; Zhong, Zi-xing; Wang, Qi-qi; Huang, Ping; Liu, Su-xiao
- Abstract
Cyclosporine A (CsA) is a commonly used immunosuppressant, but its association with thrombotic microangiopathy (TMA) is rarely reported. In recent years, CsA has been used in pregnant women with autoimmune diseases or previous immune-related adverse pregnancies. Our case involves a 34-year-old female who developed typical laboratory indicators of TMA while using CsA to improve pregnancy outcomes. After discontinuing CsA, the TMA markers gradually normalized. To our knowledge, this is the first report of CsA-induced TMA during pregnancy. We also reviewed previous case reports of CsA-induced TMA and summarized the possible mechanisms, characteristics, and risk factors, as well as methods to identify this rare adverse effect of CsA in pregnant women.
- Subjects
PREGNANCY complications; PREGNANCY outcomes; PREGNANT women; CYCLOSPORINE; PREGNANCY
- Publication
SAGE Open Medical Case Reports, 2025, p1
- ISSN
2050-313X
- Publication type
Academic Journal
- DOI
10.1177/2050313X241308693