Synthesis of pyrophosphate analogues and their cytotoxic activities.

Nguyen, Van-Tai; Pham, Minh-Quan; Vu, Thi-Ha; Tran, Thi-Hong-Ha; Doan, Duy-Tien; Nguyen, Dinh-Luyen; Le, Phong; Luu, Van-Chinh

Six pyrophosphate analogues are prepared from zerumbone, murrayafoline A, acridone, and 4-hydroxycoumarin via 1,3-dipolar cycloaddition reactions. Their in vitro cytotoxic activity is evaluated against HepG2, LU-1, and HeLa cancer cell lines. Among them, diisopropyl ((ethoxy((4-((1-methoxy-3-methyl-9 H -carbazol-9-yl)methyl)-1 H -1,2,3-triazol-1-yl)methyl)phosphoryl)methyl)phosphonate (6a) and diisopropyl ((ethoxy((4-(((3-methyl-9 H -carbazol-1-yl)oxy)methyl)-1 H -1,2,3-triazol-1-yl)methyl)phosphoryl)methyl)phosphonate (6b) are found to show activity against HepG2, LU-1, and HeLa cancer cell lines, with IC50 values ranging from 7.31 to 17.88 μM.

PYROPHOSPHATES; HELA cells; CANCER cells; CELL lines; RING formation (Chemistry)

Journal of Chemical Research, 2021, Vol 45, Issue 11/12, p992

1747-5198

Academic Journal

10.1177/17475198211043439