Works matching DE "DIHYDROPYRIMIDINE dehydrogenase"

Results: 320

DPYD Genotyping, Fluoropyrimidine Dosage and Toxicity: An Umbrella Review of Systematic Reviews.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 5, p. 727, doi. 10.3390/ph18050727

By:

Otero-Torres, Sara;
Rodríguez-Mauriz, Rosa;
Fort-Casamartina, Eduard;
Clopés-Estela, Ana;
Soler-Rotllant, Francesc;
Fontanals-Martínez, Sandra;
Montero-Pérez, Olalla

Publication type:

Article

Cumulus cell pappalysin-1, luteinizing hormone/choriogonadotropin receptor, amphiregulin and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 mRNA levels associate with oocyte developmental competence and embryo outcomes.

Published in:

Journal of Assisted Reproduction & Genetics, 2019, v. 36, n. 7, p. 1457, doi. 10.1007/s10815-019-01489-8

By:

Kordus, Richard J.;
Hossain, Akhtar;
Corso, Michael C.;
Chakraborty, Hrishikesh;
Whitman-Elia, Gail F.;
LaVoie, Holly A.

Publication type:

Article

Indirect assessment of dihydropyrimidine dehydrogenase activity in cats.

Published in:

Veterinary & Comparative Oncology, 2013, v. 11, n. 4, p. 265, doi. 10.1111/vco.12064

By:

Saba, C. F.;
Schmiedt, C. W.;
Freeman, K. G.;
Edwards, G. L.

Publication type:

Article

Frequency of dihydropyrimidine dehydrogenase and UDP-glucuronosyltransferase 1A1 variants in cancer patients requiring chemotherapy: A single-center study in southern India.

Published in:

Journal of Clinical & Basic Research, 2023, v. 7, n. 1, p. 6, doi. 10.61186/jcbr.7.1.6

By:

Gangavarapu, Kevin;
Bora, Nandini Shyamali;
Srinivas, Maddali;
Hasan, Qurratulain

Publication type:

Article

Genetic and Functional Characterization of DPYD Exon 4 Deletion Common in the Finnish Population.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2025, v. 136, n. 3, p. 1, doi. 10.1111/bcpt.70011

By:

Kiiski, Johanna I.;
Khan, Sofia;
Hosio, Antti;
Neuvonen, Mikko;
Niemi, Mikko

Publication type:

Article

DPYD genotyping and dihydropyrimidine dehydrogenase (DPD) phenotyping in clinical oncology. A clinically focused minireview.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2022, v. 131, n. 5, p. 325, doi. 10.1111/bcpt.13782

By:

Paulsen, Niels Herluf;
Vojdeman, Fie;
Andersen, Stig Ejdrup;
Bergmann, Troels K.;
Ewertz, Marianne;
Plomgaard, Peter;
Hansen, Morten Rix;
Esbech, Peter Skov;
Pfeiffer, Per;
Qvortrup, Camilla;
Damkier, Per

Publication type:

Article

Characterization of Genes for Beef Marbling Based on Applying Gene Coexpression Network.

Published in:

International Journal of Genomics, 2014, p. 1, doi. 10.1155/2014/708562

By:

Dajeong Lim;
Nam-Kuk Kim;
Seung-Hwan Lee;
Hye-Sun Park;
Yong-Min Cho;
Han-Ha Chai;
Heebal Kim

Publication type:

Article

Intratumoural expression of dihydropyrimidine dehydrogenase is an independent prognostic factor in resected pancreatic ductal adenocarcinoma treated with adjuvant gemcitabine.

Published in:

Oncology Letters, 2025, v. 29, n. 2, p. N.PAG, doi. 10.3892/ol.2024.14845

By:

Blomstrand, Hakon;
Bodarve, Malin;
Groth, Fredrik;
Naredi, Peter;
Sund, Malin;
Vilhav, Caroline;
Green, Henrik;
Björnsson, Bergthor;
Öhlund, Daniel;
Lindblad, Stina;
Franklin, Oskar;
Elander, Nils O.

Publication type:

Article

Determination of thymidine phosphorylase expression level facilitates recurrence risk stratification in stage II/III colorectal cancer following adjuvant chemotherapy with oral fluoropyrimidines.

Published in:

Oncology Letters, 2019, v. 17, n. 6, p. 5267

By:

Kugimiya, Naruji;
Harada, Eijiro;
Suehiro, Yuki;
Suga, Atsushi;
Takemoto, Yoshihiro;
Hamano, Kimikazu

Publication type:

Article

5-Fluorouracil-based adjuvant chemotherapy improves the clinical outcomes of patients with lymphovascular invasion of upper urinary tract cancer and low expression of dihydropyrimidine dehydrogenase.

Published in:

Oncology Letters, 2019, v. 17, n. 5, p. 4429

By:

Narimatsu, Takahiro;
Kambara, Tsunehito;
Abe, Hideyuki;
Uematsu, Toshitaka;
Tokura, Yuumi;
Suzuki, Issei;
Sakamoto, Kazumasa;
Takei, Kouhei;
Nishihara, Daisaku;
Nakamura, Gaku;
Kokubun, Hidetoshi;
Yuki, Hideo;
Betsunoh, Hironori;
Kamai, Takao

Publication type:

Article

Clinical implications of dihydropyrimidine dehydrogenase expression in patients with pancreatic cancer who undergo curative resection with S-1 adjuvant chemotherapy.

Published in:

Oncology Letters, 2017, v. 14, n. 2, p. 1505, doi. 10.3892/ol.2017.6295

By:

MASAAKI MURAKAWA;
TORU AOYAMA;
YOHEI MIYAGI;
YOSUKE ATSUMI;
KEISUKE KAZAMA;
KOICHIRO YAMAOKU;
AMANE KANAZAWA;
MANABU SHIOZAWA;
SATOSHI KOBAYASHI;
MAKOTO UENO;
MANABU MORIMOTO;
NAOTO YAMAMOTO;
TAKASHI OSHIMA;
TAKAKI YOSHIKAWA;
YASUSHI RINO;
MUNETAKA MASUDA;
SOICHIRO MORINAGA

Publication type:

Article

Elevated levels of mRNAs encoding dihydropyrimidine dehydrogenase and thymidylate synthase are associated with improved survival of patients with hepatocellular carcinoma treated with S-1.

Published in:

Oncology Letters, 2017, v. 14, n. 1, p. 930, doi. 10.3892/ol.2017.6241

By:

YUSUKE OKANO;
MASAKAZU YAMAMOTO;
SATOSHI KATAGIRI;
GO NAKAJIMA;
HIDEKAZU KURAMOCHI

Publication type:

Article

Thymidine phosphorylase affects clinical outcome following surgery and mRNA expression levels of four key enzymes for 5-fluorouracil metabolism in patients with stage I and II non-small cell lung cancer.

Published in:

Molecular & Clinical Oncology, 2018, v. 9, n. 6, p. 640, doi. 10.3892/mco.2018.1726

By:

Himuro, Naoya;
Niiya, Yumiko;
Minakata, Takao;
Oshima, Yutaka;
Kataoka, Daisuke;
Yamamoto, Shigeru;
Suzuki, Takashi;
Kadokura, Mitsutaka

Publication type:

Article

Year-Long Stability of Nucleic Acid Bases in Concentrated Sulfuric Acid: Implications for the Persistence of Organic Chemistry in Venus' Clouds.

Published in:

Life (2075-1729), 2024, v. 14, n. 5, p. 538, doi. 10.3390/life14050538

By:

Seager, Sara;
Petkowski, Janusz J.;
Seager, Maxwell D.;
Grimes Jr., John H.;
Zinsli, Zachary;
Vollmer-Snarr, Heidi R.;
Abd El-Rahman, Mohamed K.;
Wishart, David S.;
Lee, Brian L.;
Gautam, Vasuk;
Herrington, Lauren;
Bains, William;
Darrow, Charles

Publication type:

Article

DPD Testing Before Treatment With Fluoropyrimidines in the Amsterdam UMCs: An Evaluation of Current Pharmacogenetic Practice.

Published in:

Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2019.01609

By:

Martens, Forike K.;
Huntjens, Daan W.;
Rigter, Tessel;
Bartels, Meike;
Bet, Pierre M.;
Cornel, Martina C.

Publication type:

Article

A patient with a severe allergic reaction secondary to Efudix 5% cream.

Published in:

Clinical & Experimental Dermatology, 2023, v. 48, n. 6, p. 699, doi. 10.1093/ced/llad072

By:

Lam, Mun Wai;
Cuell, Alexis

Publication type:

Article

Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple DPYD Variants.

Published in:

Genes, 2018, v. 9, n. 12, p. 585, doi. 10.3390/genes9120585

By:

Lunenburg, Carin A. T. C.;
Henricks, Linda M.;
van Kuilenburg, André B. P.;
Mathijssen, Ron H. J.;
Schellens, Jan H. M.;
Gelderblom, Hans;
Guchelaar, Henk-Jan;
Swen, Jesse J.

Publication type:

Article

Alternative chemoradiotherapy in anal carcinoma patients with mutations in thymidylate synthase and dihydropyrimidine dehydrogenase genes.

Published in:

Therapeutic Advances in Gastroenterology, 2021, v. 14, p. 1, doi. 10.1177/17562848211024464

By:

Saif, Muhammad Wasif M.;
Hamal, Ruchi;
Siddiqui, Nauman;
Maloney, Antonia;
Smith, Melissa

Publication type:

Article

Alternative chemoradiotherapy in anal carcinoma patients with mutations in thymidylate synthase and dihydropyrimidine dehydrogenase genes.

Published in:

Therapeutic Advances in Gastroenterology, 2021, v. 14, p. 1, doi. 10.1177/17562848211024464

By:

Saif, MW;
Hamal, Ruchi;
Siddiqui, Nauman;
Maloney, Antonia;
Smith, Melissa

Publication type:

Article

Highly Regioselective Addition of Organozinc Reagents to 2-Oxo-1,2-dihydropyrimidine-5-carboxylates Activated by BF<sub>3</sub>·OEt<sub>2</sub>: Synthesis of 2-Oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates.

Published in:

European Journal of Organic Chemistry, 2013, v. 2013, n. 27, p. 6124, doi. 10.1002/ejoc.201300539

By:

Singh, Kamaljit;
Chopra, Rakesh

Publication type:

Article

An in vitro approach to simulate the process of 5-fluorouracil degradation with dihydropyrimidine dehydrogenase: the process in accordance to the first-order kinetic reaction.

Published in:

Xenobiotica, 2021, v. 51, n. 1, p. 24, doi. 10.1080/00498254.2020.1799451

By:

Qin, Wei;
Wang, Xiaoxue;
Chen, Wenqian;
Du, Wenwen;
Zhang, Dan;
Zhang, Xianglin;
Li, Pengmei

Publication type:

Article

Conflicting alterations in hepatic expression of CYP3A and enzyme kinetics in rats exposed to 5-fluorouracil: relevance to pharmacokinetics of midazolam.

Published in:

Xenobiotica, 2019, v. 49, n. 12, p. 1470, doi. 10.1080/00498254.2019.1578004

By:

Fukuno, Shuhei;
Nagai, Katsuhito;
Fujiike, Mai;
Sasaki, Yuya;
Konishi, Hiroki

Publication type:

Article

Response to Letter: Cost Implications of Reactive Versus Prospective Testing for Dihydropyrimidine Dehydrogenase Deficiency in Patients With Colorectal Cancer: A Single-Institution Experience.

Published in:

2019

By:

O'Farrell, Eoin;
Bird, Brian;
Murphy, Con

Publication type:

Letter

Cost Implications of Reactive Versus Prospective Testing for Dihydropyrimidine Dehydrogenase Deficiency in Patients With Colorectal Cancer: A Single-Institution Experience.

Published in:

Dose-Response, 2018, v. 16, n. 4, p. 1, doi. 10.1177/1559325818803042

By:

Murphy, Con;
Byrne, Stephen;
Ahmed, Gul;
Kenny, Andrew;
Gallagher, James;
Harvey, Harry;
O'Farrell, Eoin;
Bird, Brian

Publication type:

Article

Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms.

Published in:

World Journal of Surgical Oncology, 2020, v. 18, n. 1, p. 1, doi. 10.1186/s12957-020-02103-3

By:

Deng, Xunwei;
Hou, Jingyuan;
Deng, Qiaoting;
Zhong, Zhixiong

Publication type:

Article

S-1 for treatment of advanced hepatocellular carcinoma: a systematic review of the literature.

Published in:

Contemporary Oncology / Współczesna Onkologia, 2017, v. 21, n. 1, p. 16, doi. 10.5114/wo.2017.66653

By:

Wu-kui Huang;
Li-na You;
Shu-fa Yang;
Deng-yao Liu;
Mo Liu;
Xi-wen Fan

Publication type:

Article

Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma.

Published in:

BMC Cancer, 2012, v. 12, n. 1, p. 420, doi. 10.1186/1471-2407-12-420

By:

Ide, Hiroki;
Kikuchi, Eiji;
Hasegawa, Masanori;
Kozakai, Norihide;
Kosaka, Takeo;
Miyajima, Akira;
Oya, Mototsugu

Publication type:

Article

DPYD and fluoropyrimidines: Using the data as our guide.

Published in:

Pharmacotherapy, 2024, v. 44, n. 12, p. 896, doi. 10.1002/phar.4634

By:

Walko, Christine M.

Publication type:

Article

Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer.

Published in:

Gastric Cancer, 2015, v. 18, n. 3, p. 538, doi. 10.1007/s10120-014-0413-8

By:

Sasako, Mitsuru;
Terashima, Masanori;
Ichikawa, Wataru;
Ochiai, Atsushi;
Kitada, Koji;
Kurahashi, Issei;
Sakuramoto, Shinichi;
Katai, Hitoshi;
Sano, Takeshi;
Imamura, Hiroshi

Publication type:

Article

Erratum to: Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer.

Published in:

2015

By:

Sasako, Mitsuru;
Terashima, Masanori;
Ichikawa, Wataru;
Ochiai, Atsushi;
Kitada, Koji;
Kurahashi, Issei;
Sakuramoto, Shinichi;
Katai, Hitoshi;
Sano, Takeshi;
Imamura, Hiroshi

Publication type:

Erratum

S-1 review from preclinical pharmacology.

Published in:

Gastric Cancer, 2013, p. 3, doi. 10.1007/s10120-008-0488-1

By:

Fukushima, Masakazu

Publication type:

Article

La dihydropyrimidine déshydrogénase (DPD).

Published in:

Oncologie (Tech Science Press), 2014, v. 16, n. 2/3, p. 96, doi. 10.1007/s10269-014-2373-3

By:

Gamelin, E.;
Boisdron-Celle, M.;
Morel, A.

Publication type:

Article

Synthesis and Characterization of Two 3,4-Dihydropyrimidinone Derivatives.

Published in:

Diyala Journal for Pure Science, 2018, v. 14, n. 4, p. 170, doi. 10.24237/djps.1404.463B

By:

Ali, Noor Raisan;
Magtoof, Mahmood Shakir

Publication type:

Article

A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations.

Published in:

Modern Rheumatology, 2012, v. 22, n. 1, p. 52, doi. 10.3109/s10165-011-0467-y

By:

Meziani, Roubila;
Yamada, Ryo;
Takahashi, Meiko;
Ohigashi, Kenei;
Morinobu, Akio;
Terao, Chikashi;
Hiratani, Hitomi;
Ohmura, Koichiro;
Yamaguchi, Masao;
Nomura, Takashi;
Vasilescu, Alexandre;
Kokubo, Miki;
Renault, Victor;
Hirosawa, Katsura;
Ratanajaraya, Chanavee;
Heath, Simon;
Mimori, Tsuneyo;
Sakaguchi, Shimon;
Lathrop, Mark;
Melchers, Inga

Publication type:

Article

Eritrodisestesia palmoplantar tras tratamiento perioperatorio con quimioterapia.

Published in:

Sanidad Militar, 2022, v. 78, n. 4, p. 258, doi. 10.4321/S1887-85712022000400009

By:

Granda-Lobato, P.;
Sánchez-López, P.;
Pacheco-Barcia, V.;
Prats-Oliván, P.;
Gonzalo-Salado, M. H.;
Barrena-Castello, G.

Publication type:

Article

Colon Cancer Pharmacogenetics: A Narrative Review.

Published in:

Pharmacy, 2022, v. 10, n. 4, p. 95, doi. 10.3390/pharmacy10040095

By:

Alfaro Alfaro, Álvaro Esteban;
Murillo Castillo, Brayan;
Cordero García, Eugenia;
Tascón, Javier;
Morales, Ana I.

Publication type:

Article

Crystal structure of gluconate 5‐dehydrogenase from Lentibacter algarum.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2020, v. 76, n. 5, p. 228, doi. 10.1107/S2053230X20005336

By:

Tian, Dengke;
Fu, Xueqi;
Cao, Wenqiang;
Yuan, Hong

Publication type:

Article

Crystal structure of the flavin‐dependent thymidylate synthase Thy1 from Thermus thermophilus with an extra C‐terminal domain.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2019, v. 75, n. 6, p. 450, doi. 10.1107/S2053230X19007192

By:

Ogawa, Aoba;
Sampei, Gen-ichi;
Kawai, Gota

Publication type:

Article

A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS‐114.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 5, p. 604, doi. 10.1002/psp4.12747

By:

Araki, Hikari;
Takenaka, Toru;
Takahashi, Koichi;
Yamashita, Fumiaki;
Matsuoka, Kazuaki;
Yoshisue, Kunihiro;
Ieiri, Ichiro

Publication type:

Article

Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 12, p. 940, doi. 10.1002/psp4.12474

By:

Jacobs, Bart A.W.;
Deenen, Maarten J.;
Joerger, Markus;
Rosing, Hilde;
Vries, Niels;
Meulendijks, Didier;
Cats, Annemieke;
Beijnen, Jos H.;
Schellens, Jan H.M.;
Huitema, Alwin D.R.

Publication type:

Article

Cancer genomic profiling identified dihydropyrimidine dehydrogenase deficiency in bladder cancer promotes sensitivity to gemcitabine.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12528-3

By:

Tsukahara, Shigehiro;
Shiota, Masaki;
Takamatsu, Dai;
Nagakawa, Shohei;
Matsumoto, Takashi;
Kiyokoba, Ryo;
Yagi, Mikako;
Setoyama, Daiki;
Noda, Nozomi;
Matsumoto, Shinya;
Hayashi, Tetsutaro;
Contreras-Sanz, Alberto;
Black, Peter C.;
Inokuchi, Junichi;
Kohashi, Kenichi;
Oda, Yoshinao;
Uchiumi, Takeshi;
Eto, Masatoshi;
Kang, Dongchon

Publication type:

Article

Commentary: The pharmacogenomic landscape of an Indigenous Australian population.

Published in:

Frontiers in Pharmacology, 2024, p. 01, doi. 10.3389/fphar.2024.1373056

By:

White, Cassandra;
Paul, Christine;
Scott, Rodney J.;
Ackland, Stephen

Publication type:

Article

Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1376638

By:

Escalante, Paula I.;
Quiñones, Luis A.;
Contreras, Héctor R.

Publication type:

Article

Implementing pharmacogenetic testing in fluoropyrimidine-treated cancer patients: DPYD genotyping to guide chemotherapy dosing in Greece.

Published in:

Frontiers in Pharmacology, 2023, p. 01, doi. 10.3389/fphar.2023.1248898

By:

Ragia, Georgia;
Maslarinou, Anthi;
Atzemian, Natalia;
Biziota, Eirini;
Koukaki, Triantafyllia;
Ioannou, Charalampia;
Balgkouranidou, Ioanna;
Kolios, George;
Kakolyris, Stylianos;
Xenidis, Nikolaos;
Amarantidis, Kyriakos;
Manolopoulos, Vangelis G.

Publication type:

Article

Implementation of pharmacogenetic testing in oncology: DPYD-guided dosing to prevent fluoropyrimidine toxicity in British Columbia.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1257745

By:

Wu, Angela;
Anderson, Helen;
Hughesman, Curtis;
Young, Sean;
Lohrisch, Caroline;
Ross, Colin J. D.;
Carleton, Bruce C.

Publication type:

Article

Identification of dihydropyrimidine dehydrogenase as a virulence factor essential for the survival of Entamoeba histolytica in glucose-poor environments.

Published in:

Cellular Microbiology, 2013, v. 15, n. 1, p. 130, doi. 10.1111/cmi.12036

By:

Baumel‐Alterzon, Sharon;
Weber, Christian;
Guillén, Nancy;
Ankri, Serge

Publication type:

Article

DPYD, down-regulated by the potentially chemopreventive agent luteolin, interacts with STAT3 in pancreatic cancer.

Published in:

Carcinogenesis, 2021, v. 42, n. 7, p. 940, doi. 10.1093/carcin/bgab017

By:

Kato, Hiroyuki;
Naiki-Ito, Aya;
Suzuki, Shugo;
Inaguma, Shingo;
Komura, Masayuki;
Nakao, Kenju;
Naiki, Taku;
Kachi, Kenta;
Kato, Akihisa;
Matsuo, Yoichi;
Takahashi, Satoru

Publication type:

Article

The beneficial influence of rhubarb on 5-fluorouracil-induced ileal mucositis and the combined role of aquaporin-4, tumour necrosis factor-α, nuclear factor-kappa B & matrix metalloproteinase-9 in rat model: histological study.

Published in:

Anatomy & Cell Biology, 2020, v. 53, n. 2, p. 228, doi. 10.5115/acb.20.014

By:

Kamar, Samaa Samir;
Baky, Mostafa Hasan;
Omar, Abeer Ibraheem

Publication type:

Article

Dihydropyrimidine dehydrogenase deficiency in patients with severe toxicity after 5-fluorouracil: a retrospective single-center study.

Published in:

Annals of Gastroenterology, 2021, v. 34, n. 1, p. 68, doi. 10.20524/aog.2020.0551

By:

Detailleur, Stephanie;
Segelov, Eva;
Re, Marzia Del;
Prenen, Hans

Publication type:

Article

Micro RNA-494 sensitizes colon cancer cells to fluorouracil through regulation of DPYD.

Published in:

IUBMB Life, 2015, v. 67, n. 3, p. 191, doi. 10.1002/iub.1361

By:

Chai, Jie;
Dong, Wei;
Xie, Chao;
Wang, Lin;
Han, Da‐Li;
Wang, Shan;
Guo, Hong‐Liang;
Zhang, Zong‐Li

Publication type:

Article